Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 987776..988301 Replicon chromosome
Accession NZ_CP092358
Organism Wielerella bovis strain 09LB414

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MIS46_RS05000 Protein ID WP_249443569.1
Coordinates 988035..988301 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MIS46_RS04995 Protein ID WP_249443568.1
Coordinates 987776..988048 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIS46_RS04975 (MIS46_04975) 982868..985063 - 2196 WP_249443564.1 TonB-dependent siderophore receptor -
MIS46_RS04980 (MIS46_04980) 985325..985933 - 609 WP_249443565.1 lytic transglycosylase domain-containing protein -
MIS46_RS04985 (MIS46_04985) 986127..986723 + 597 WP_249443566.1 hypothetical protein -
MIS46_RS04990 (MIS46_04990) 986791..987690 + 900 WP_249443567.1 aldo/keto reductase -
MIS46_RS04995 (MIS46_04995) 987776..988048 + 273 WP_249443568.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MIS46_RS05000 (MIS46_05000) 988035..988301 + 267 WP_249443569.1 type II toxin-antitoxin system YafQ family toxin Toxin
MIS46_RS05005 (MIS46_05005) 988355..988819 + 465 WP_249443570.1 hypothetical protein -
MIS46_RS05010 (MIS46_05010) 988896..989966 + 1071 WP_249443571.1 3-isopropylmalate dehydrogenase -
MIS46_RS05015 (MIS46_05015) 990698..991927 + 1230 WP_249443572.1 sodium/glutamate symporter -
MIS46_RS05020 (MIS46_05020) 992032..993141 + 1110 WP_249443573.1 lysozyme inhibitor LprI family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(2-75)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10213.83 Da        Isoelectric Point: 7.3201

>T235948 WP_249443569.1 NZ_CP092358:988035-988301 [Wielerella bovis]
MKKIDYTNQFKRDAKKHFLALATAQWTEVMYCLINDLPVPIQYRDHALTGNLRDLRDCHIQLDLVLLYAKNDDTITLVRL
GSHSELGL

Download         Length: 267 bp

>T235948 NZ_LR134503:c2250882-2250598 [Kaistella jeonii]
ATGAATACAACAAAATTTGACATTGCAGATTACTTGGACAATAACGAAATGATTGCAGAATATCTTAATACTGTTCTGGA
AGAAGGAAATGACTCAGATATAATTGTCGCAATTGGAACTGTTGCTAAAGCGATTGGAATGACTAAAATTGCAGAAGAAA
CAGGACTTAGTAGACCGAGTTTATACAAAGCGTTATCAGACGGTGCTAAACCACAATTCGCAACAATAATGAAAGTTCTT
AAAGCCGTTGGTGGACAATTACATGTGAATCCTACTACAGCGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10277.59 Da        Isoelectric Point: 4.5238

>AT235948 WP_249443568.1 NZ_CP092358:987776-988048 [Wielerella bovis]
MANINIRVDDDLKKQSFAVIERFGMTPSQAFKMFLTQIAHTNTIPLSLDYQNINYEANPTTMQAIEDYRKGRVESCSSLD
DLMDGLNEKN

Download         Length: 273 bp

>AT235948 NZ_LR134503:c2251187-2250888 [Kaistella jeonii]
ATGTACTTTATTGAAAAAACAGAAGAGTTTGACAAATGGTTTAGAAAATTGAATGATTTAAGAGCAAAAGCAAAAATTTT
GTTTCGAATTCAGAAATTAGAAACTGACGAACATTTCGGCGATTTTAAACCAGTTGGAAATGGAATTAATGAGTTGAAGA
TTAATTACGCAAAAGGTTATAGAATTTACTTTAAGGAGACTGAGGGAAAAATCATTATTCTTCTAATTGGCGGAGATAAA
TCAACTCAACAAAAGGACATTGAAAAAGCGTTTCAAATCTGGAATAAATTAAAGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References