Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2376910..2377484 Replicon chromosome
Accession NZ_CP092344
Organism Rhizobium gallicum strain M101

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L2W42_RS12035 Protein ID WP_239595112.1
Coordinates 2376910..2377275 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L2W42_RS12040 Protein ID WP_194729179.1
Coordinates 2377269..2377484 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2W42_RS12015 (L2W42_12015) 2371970..2372524 - 555 WP_194729182.1 HdeD family acid-resistance protein -
L2W42_RS12020 (L2W42_12020) 2372667..2373251 + 585 WP_074066971.1 transcriptional regulator BetI -
L2W42_RS12025 (L2W42_12025) 2373316..2374779 + 1464 WP_239595108.1 betaine-aldehyde dehydrogenase -
L2W42_RS12030 (L2W42_12030) 2374839..2376488 + 1650 WP_239595110.1 choline dehydrogenase -
L2W42_RS12035 (L2W42_12035) 2376910..2377275 - 366 WP_239595112.1 type II toxin-antitoxin system VapC family toxin Toxin
L2W42_RS12040 (L2W42_12040) 2377269..2377484 - 216 WP_194729179.1 CopG family transcriptional regulator Antitoxin
L2W42_RS12045 (L2W42_12045) 2377543..2378019 - 477 WP_074066966.1 DUF2214 domain-containing protein -
L2W42_RS12050 (L2W42_12050) 2378024..2378410 - 387 WP_028739821.1 DUF6152 family protein -
L2W42_RS12055 (L2W42_12055) 2378550..2378996 - 447 WP_022716377.1 Rrf2 family transcriptional regulator -
L2W42_RS12060 (L2W42_12060) 2379420..2380160 + 741 WP_239595114.1 phosphoadenylyl-sulfate reductase -
L2W42_RS12065 (L2W42_12065) 2380319..2381272 + 954 WP_022716380.1 sulfate adenylyltransferase subunit CysD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-106)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-40)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13635.66 Da        Isoelectric Point: 6.2250

>T235936 WP_239595112.1 NZ_CP092344:c2377275-2376910 [Rhizobium gallicum]
MVKALFDTNILIDYLNAIPEARDELDRYGRRAISVVTWMEVLIGADPDVEAATRSFLNNFQIIAVDNAIAEGAVRLRQHH
RIKLPDAIIWSTADAHALLLVTRNTKDFPADNPGIRVPYLR

Download         Length: 366 bp

>T235936 NZ_LR134494:c3915452-3915183 [Serratia quinivorans]
ATGCGGATAGAATGGAGCAGTGAAGCTCAGGAAGAGCTATGGAGCATTATTGATTATATTGATGACAGAAATCCGCGGGC
TGCGCGAAAATTGCAGCACGAAATCGAAGCGGTGGTACTTTCCCTGCCGTTAAACCCCTTAATGCATCGTTTGGGTAGGG
TAGATAATACGCGTGAAATTGTCGTCCATCCCAACTACCTGATTGTTTATAGAATCATCGGGCATATAGAAGTTCTTAGT
GTTATTCACGCCAAGCGGGAATATCCGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8306.51 Da        Isoelectric Point: 8.6003

>AT235936 WP_194729179.1 NZ_CP092344:c2377484-2377269 [Rhizobium gallicum]
MRILVDIVESELKALDKMAKSEKVSRASLIRKAVNDFLDRHDRTKEAEAFGLWGNRKIDGLEYQDKVRSEW

Download         Length: 216 bp

>AT235936 NZ_LR134494:c3915650-3915456 [Serratia quinivorans]
ATGGCGATAAAACCTCCACTTTCTACCTTGCCGGTGCTGGGTTCGGCCGAACAAACAGAGAGCTACGATCGGTGGTATCG
GGCCAAGGTTGAATCAGCCATTAACAGTGAGCAGCCAAGAATTCCGCACGAACAGGTGATGACTGAACTGCAAGCTCGTT
TAGCAGCAAAGAAAAAATTGCGCAAAATGGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References