Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 4960694..4962375 | Replicon | chromosome |
| Accession | NZ_CP092336 | ||
| Organism | Klebsiella pneumoniae strain KPN20 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | - |
| Locus tag | MG291_RS23885 | Protein ID | WP_004178299.1 |
| Coordinates | 4960694..4961611 (-) | Length | 306 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | A6TH05 |
| Locus tag | MG291_RS23890 | Protein ID | WP_004177809.1 |
| Coordinates | 4961617..4962375 (-) | Length | 253 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MG291_RS23865 (4956000) | 4956000..4957520 | + | 1521 | WP_002885173.1 | sugar ABC transporter ATP-binding protein | - |
| MG291_RS23870 (4957517) | 4957517..4958515 | + | 999 | WP_002885172.1 | ribose ABC transporter permease | - |
| MG291_RS23875 (4958546) | 4958546..4959487 | + | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
| MG291_RS23880 (4959562) | 4959562..4960569 | + | 1008 | WP_004178300.1 | carbohydrate kinase family protein | - |
| MG291_RS23885 (4960694) | 4960694..4961611 | - | 918 | WP_004178299.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| MG291_RS23890 (4961617) | 4961617..4962375 | - | 759 | WP_004177809.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| MG291_RS23895 (4962461) | 4962461..4963189 | - | 729 | WP_004178298.1 | response regulator transcription factor | - |
| MG291_RS23900 (4963462) | 4963462..4965609 | + | 2148 | WP_012737173.1 | formate dehydrogenase H subunit alpha, selenocysteine-containing | - |
| MG291_RS23905 (4965606) | 4965606..4965749 | - | 144 | WP_022631365.1 | hypothetical protein | - |
| MG291_RS23910 (4966187) | 4966187..4966873 | + | 687 | WP_004151733.1 | tetratricopeptide repeat protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34649.06 Da Isoelectric Point: 5.4707
>T235930 WP_004178299.1 NZ_CP092336:c4961611-4960694 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
>T235930 NZ_LR134493:3624374-3624814 [Serratia rubidaea]
ATGATCACGCATATGCTGGATACCAATATTGTCATCTATGTGATCAAGCGTCGACCGCGTGAAGTGCTGGCGCTATTTAA
TCAGCACGCGGGAAAAATGGCGATATCTGCCGTGACCTATGGTGAGCTTGTACACGGTGTGGAAAAGAGCGCCAGGCAGG
TTGAGAATCTGCGCGTCGTCGAGGATTTTGTTTCCCGGCTGGACGTTTTGCCCTACACCGACAAGGCGGCTGCACACTAC
GGCAATATTCGCGCCGATCTTGAACGTAAAGGCTCGCCGATTGGGGTTAACGACCTGCATATTGCCGGCCATGCCCGCAG
TGAAGGCTTGGTATTGGTCAGCAATAATTTGCACGAGTTTGCCCGCATCGACGGTCTGAGGCTGGAAAACTGGTTGTCAT
CACCAATCATTCCGCCATCTCGTCCCTCATCCTCGAAATAA
ATGATCACGCATATGCTGGATACCAATATTGTCATCTATGTGATCAAGCGTCGACCGCGTGAAGTGCTGGCGCTATTTAA
TCAGCACGCGGGAAAAATGGCGATATCTGCCGTGACCTATGGTGAGCTTGTACACGGTGTGGAAAAGAGCGCCAGGCAGG
TTGAGAATCTGCGCGTCGTCGAGGATTTTGTTTCCCGGCTGGACGTTTTGCCCTACACCGACAAGGCGGCTGCACACTAC
GGCAATATTCGCGCCGATCTTGAACGTAAAGGCTCGCCGATTGGGGTTAACGACCTGCATATTGCCGGCCATGCCCGCAG
TGAAGGCTTGGTATTGGTCAGCAATAATTTGCACGAGTTTGCCCGCATCGACGGTCTGAGGCTGGAAAACTGGTTGTCAT
CACCAATCATTCCGCCATCTCGTCCCTCATCCTCGAAATAA
Antitoxin
Download Length: 253 a.a. Molecular weight: 28548.92 Da Isoelectric Point: 10.0870
>AT235930 WP_004177809.1 NZ_CP092336:c4962375-4961617 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
>AT235930 NZ_LR134493:3624141-3624377 [Serratia rubidaea]
ATGACTATCGGTTCCGTTTTTACCAATAATCGCTCGCAGGCGGTACGTTTGCCGGCAGAGGCGCGTTTTCCTGATTCGGT
GTCGAAAGTGACGGTACGCGTGGTGGGTAAAGAGCGCGTTCTGGCCCCGGTGGAAAATACCTGGGACAGCTTTTTTGACC
AGGAGCGCCTGCCCGGTGATGATTTTCTGAATGAAAGAGCCGCGCAGTATCAGGCAGAGCGGGAAAGTTTTGAATGA
ATGACTATCGGTTCCGTTTTTACCAATAATCGCTCGCAGGCGGTACGTTTGCCGGCAGAGGCGCGTTTTCCTGATTCGGT
GTCGAAAGTGACGGTACGCGTGGTGGGTAAAGAGCGCGTTCTGGCCCCGGTGGAAAATACCTGGGACAGCTTTTTTGACC
AGGAGCGCCTGCCCGGTGATGATTTTCTGAATGAAAGAGCCGCGCAGTATCAGGCAGAGCGGGAAAGTTTTGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|