Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4804221..4804737 Replicon chromosome
Accession NZ_CP092336
Organism Klebsiella pneumoniae strain KPN20

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag MG291_RS23090 Protein ID WP_004178374.1
Coordinates 4804221..4804505 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag MG291_RS23095 Protein ID WP_002886901.1
Coordinates 4804495..4804737 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MG291_RS23065 (4799705) 4799705..4799968 - 264 WP_020324507.1 PTS system, lactose/cellobiose-specific IIB subunit -
MG291_RS23070 (4800098) 4800098..4800271 + 174 WP_032408826.1 hypothetical protein -
MG291_RS23075 (4800274) 4800274..4801017 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
MG291_RS23080 (4801374) 4801374..4803512 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
MG291_RS23085 (4803753) 4803753..4804217 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MG291_RS23090 (4804221) 4804221..4804505 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MG291_RS23095 (4804495) 4804495..4804737 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MG291_RS23100 (4804815) 4804815..4806725 - 1911 WP_004178373.1 PRD domain-containing protein -
MG291_RS23105 (4806748) 4806748..4807902 - 1155 WP_004178372.1 lactonase family protein -
MG291_RS23110 (4807969) 4807969..4808709 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T235929 WP_004178374.1 NZ_CP092336:c4804505-4804221 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T235929 NZ_LR134493:2635316-2635735 [Serratia rubidaea]
GTGGCCCAGTGGCGATGTGATGTCCGCATCTCCTGGCGTACTCAGCTTGTCTCGCTGTTGGCGCATGGCGCGCTGATACT
GCTGATTCTGATCTCGCCGTGGCCGGAAAGTTACGACCCGATCTGGCTGTTGCTGCTGACGCTGGTGGTTTTCGAATGTA
TTCGCAGTCAGACGCGTATTGCTTCGCGTCAGGGGGAGCTGCGCCTGCTTTCCGCGCCGCAGCGGGTGATTTGGCAGGGC
AAGGAGTGGCGGCTGGCCCGTCGCCCCTGGATGCTGCGCGGCGGCATGCTGCTGACGCTGCAGGCGAGCGGCAAGCGCAA
ACGCCGCCGGCTGTGGCTGGCGTCGGACTGTATCAGCAGCGCCGAGTGGCGGCAGTTGTGCCAGCGGATACAGCTGGCCG
AGGATGAGTCTGAAGGCTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT235929 WP_002886901.1 NZ_CP092336:c4804737-4804495 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT235929 NZ_LR134493:2635069-2635335 [Serratia rubidaea]
ATGGATATTAATAACAAAGCGCGTATTCACTGGGCTTGCCGCCGGGGAATGCGTGAACTGGACATCTCCATCATGCCGTT
TTTCGAGCATGAGTACGATTCATTGAGCGACGACGACAAGGCGCTGTTCGTGCGTCTGCTGCAGAGCGACGATCCCGATC
TGTTTAACTGGCTGATGAATCATGGCGCCCCGCAGGACGCCGAACTGCAGAGAATGGTGACGCTGATCCAGACGCGAAAT
AAAGATCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References