Detailed information of TA system TA235925

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2759791..2761379
• Replicon: chromosome
• Accession: NZ_CP092336
• Organism: Klebsiella pneumoniae strain KPN20

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: MG291_RS13345
• Protein ID: WP_004179815.1
• Coordinates: 2759791..2761113 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: MG291_RS13350
• Protein ID: WP_004176198.1
• Coordinates: 2761113..2761379 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MG291_RS13330 (2754847)	2754847..2757348	+	2502	WP_020323802.1	fimbria/pilus outer membrane usher protein	-
MG291_RS13335 (2757336)	2757336..2758340	+	1005	WP_004179822.1	fimbrial protein	-
MG291_RS13340 (2758482)	2758482..2759774	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
MG291_RS13345 (2759791)	2759791..2761113	-	1323	WP_004179815.1	type II toxin-antitoxin system HipA family toxin	Toxin
MG291_RS13350 (2761113)	2761113..2761379	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
MG291_RS13355 (2761645)	2761645..2761971	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
MG291_RS13360 (2761968)	2761968..2762468	-	501	WP_004179811.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
MG291_RS13365 (2762446)	2762446..2763825	-	1380	WP_004179808.1	nucleobase:cation symporter-2 family protein	-
MG291_RS13370 (2764171)	2764171..2765325	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
MG291_RS13375 (2765306)	2765306..2766229	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49152.42 Da
• Isoelectric Point: 7.2850

>T235925 WP_004179815.1 NZ_CP092336:c2761113-2759791 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T235925 NZ_LR134493:414700-414903 [Serratia rubidaea]
ATGACAAAAACCGACTACCTGATGCGTTTACGTAAATGCACCACTATCGATACGCTTGAAAGAGTGATTGAAAAAAACAA
GTACGCGCTCTCTGACGATGAGCTCGAGCTGTTTTACTCCGCAGCCGACCACCGTCTGGCTGAACTCACCATGAATAAGC
TGTATGACAAAATCCCGACGTCTGTTTGGAAATATGTAAGATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT235925 WP_004176198.1 NZ_CP092336:c2761379-2761113 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT235925 NZ_LR134493:414272-414640 [Serratia rubidaea]
ATGGATGAGTACTCGCCGAAACGGCATGATATTGCTCAACTCAAATTCTTGTGTGAAAATCTGTACGATGAAGGCATTGC
GACGTTGGGCGACAGCCACCACGGCTGGGTTAACGATCCGACATCGGCCGTCAATCTGCAGCTGAATGAGCTGATCGAAC
ATATTGCTTCGTTTGTGATGAGTTATAAAATAAAATACATGGACGAAAGTGACTTTTCAGAATTAGTCGAGGAGTACCTC
GACGATACCTATACGTTATTTAGTAACTACGGTATTAACGATTCCGATCTGCGTCGTTGGCAAAAAACTAAACGACGATT
ATTCAGAATGTTCTCAGGAGAGGTTTGCTGTACGAAAATGAAAACTTAG