Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 710802..711481 Replicon chromosome
Accession NZ_CP092336
Organism Klebsiella pneumoniae strain KPN20

Toxin (Protein)


Gene name ykfI Uniprot ID A0A0C7K7A4
Locus tag MG291_RS03470 Protein ID WP_020324801.1
Coordinates 711140..711481 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A0C7KEL2
Locus tag MG291_RS03465 Protein ID WP_020324792.1
Coordinates 710802..711119 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MG291_RS03440 (706016) 706016..709168 + 3153 WP_022631414.1 AIDA repeat-containing protein -
MG291_RS03445 (709261) 709261..709500 + 240 WP_020324820.1 DUF905 domain-containing protein -
MG291_RS03450 (709603) 709603..710061 + 459 WP_020324813.1 antirestriction protein -
MG291_RS03455 (710077) 710077..710553 + 477 WP_020324797.1 RadC family protein -
MG291_RS03460 (710562) 710562..710789 + 228 WP_020324796.1 DUF987 domain-containing protein -
MG291_RS03465 (710802) 710802..711119 + 318 WP_020324792.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MG291_RS03470 (711140) 711140..711481 + 342 WP_020324801.1 TA system toxin CbtA family protein Toxin
MG291_RS03475 (711597) 711597..712430 + 834 WP_020324805.1 DUF4942 domain-containing protein -
MG291_RS03485 (712733) 712733..713239 + 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
MG291_RS03490 (713339) 713339..715180 - 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimA / fimI / fimC / fimD / fimD / fimF / fimG 667947..712430 44483


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12818.91 Da        Isoelectric Point: 9.1484

>T235915 WP_020324801.1 NZ_CP092336:711140-711481 [Klebsiella pneumoniae]
MKTLPAIISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDETVIQEHIDAGITLADAVNFLVEKYGLVRIDRNGF
VWQEQSPYLRAVDILRARQATGLLRQSRNNAIR

Download         Length: 342 bp

>T235915 NZ_LR134485:4692289-4692600 [Citrobacter youngae]
GTGCATGTTATCAGCCGAAAACCATTCAATGAGGGTATGCTCATGTATCCAAACCATGGGCTTGCTCTCTCTGAGTTGCT
GAATGTTTTGGAGAAAAAAACATTCAATCACCCTGAAGAGATGAAACAGTATATTCCTTCTCTTGATAATTTTAAGTACA
GGAATAAATGGTGGGTAATTGATGTTTCTGGTAACAACCTGAGACTCATTGCCTACATAGATTTCAGGTTACATAAAGTA
TTTGTGAAGCATATCGTTCTCCACGCCGAATATGACAAACTGACAGAATATTATCGGGGCCATAAAGAATGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11915.51 Da        Isoelectric Point: 6.6246

>AT235915 WP_020324792.1 NZ_CP092336:710802-711119 [Klebsiella pneumoniae]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASMTGKFSDAECRKLDETFPHFISQMESMLITGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAVYPIQR

Download         Length: 318 bp

>AT235915 NZ_LR134485:4692597-4693043 [Citrobacter youngae]
ATGAGATCTCATCGTCATATGGACGCAGCCAGCGCAAAAAAGATCGTTGATACCTTCAGTTGTGCTGTAAAAACCATCCC
GCTTTTGGGGGAAGAACGTAATGAAACGGAGTATCGAAGGGCACTAGCGCTAGTAGAGTTTCTGGTTGACCACGACGATC
TTGAAAACCCGCTATTTGAATTACTCAGTGCCCGAATCAGTGAATACGAAAAATATGCACCAGAATTCAGAGCGCTCAAT
CAACACCTGAAACAAATCCCCTCTGGCGTTTCCGTATTGCGTACGCTCATGGATCAGTACGGATTAAAAGCCACCGACCT
CGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCCTAAATGGCCGTAGAGCACTGACTGTAAGCCATATTAAAG
CGCTTGCAGAACGCTTTAAACTTCCGGCAGATGCATTTATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7K7A4

Antitoxin

Source ID Structure
AlphaFold DB A0A0C7KEL2

References