Detailed information of TA system TA235913

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/Txe-YefM
• Location: 4564831..4565333
• Replicon: chromosome
• Accession: NZ_CP092289
• Organism: Marinobacter sp. M1C

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: MIH19_RS21585
• Protein ID: WP_249006759.1
• Coordinates: 4564831..4565094 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MIH19_RS21590
• Protein ID: WP_249006760.1
• Coordinates: 4565091..4565333 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MIH19_RS21550 (MIH19_21550)	4560095..4560505	-	411	WP_249006807.1	hypothetical protein	-
MIH19_RS21555 (MIH19_21555)	4560583..4560873	-	291	WP_249006808.1	hypothetical protein	-
MIH19_RS21560 (MIH19_21560)	4561012..4561473	-	462	WP_249018579.1	hypothetical protein	-
MIH19_RS21565 (MIH19_21565)	4561497..4562192	-	696	WP_249006810.1	GNAT family N-acetyltransferase	-
MIH19_RS21570 (MIH19_21570)	4562167..4562472	-	306	WP_217632702.1	chorismate mutase	-
MIH19_RS21575 (MIH19_21575)	4562575..4563252	-	678	WP_249006811.1	HAD family phosphatase	-
MIH19_RS21580 (MIH19_21580)	4563356..4564321	-	966	WP_249006812.1	alcohol dehydrogenase catalytic domain-containing protein	-
MIH19_RS21585 (MIH19_21585)	4564831..4565094	-	264	WP_249006759.1	Txe/YoeB family addiction module toxin	Toxin
MIH19_RS21590 (MIH19_21590)	4565091..4565333	-	243	WP_249006760.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MIH19_RS21595 (MIH19_21595)	4565493..4566053	-	561	WP_249006813.1	hypothetical protein	-
MIH19_RS21600 (MIH19_21600)	4566152..4566469	-	318	WP_249006791.1	antibiotic biosynthesis monooxygenase	-
MIH19_RS21605 (MIH19_21605)	4566985..4567209	+	225	WP_249006796.1	hypothetical protein	-
MIH19_RS21610 (MIH19_21610)	4567403..4567768	-	366	WP_249006787.1	cupin domain-containing protein	-
MIH19_RS21615 (MIH19_21615)	4568000..4568958	+	959	Protein_4266	integron integrase	-
MIH19_RS21620 (MIH19_21620)	4569052..4570110	-	1059	WP_249006814.1	ribonucleotide-diphosphate reductase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4519370..4567768	48398
	-	inside	Integron	-	-	4555287..4568836	13549

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10073.76 Da
• Isoelectric Point: 10.2588

>T235913 WP_249006759.1 NZ_CP092289:c4565094-4564831 [Marinobacter sp. M1C]
VTWKLVYTKQAQKDAKKLAASSLKPKAQGLLALIAEDPYRRPPPFEKLIGDLAGAYSRRINIQHRVVYEVLEDERVVKVL
RLWSHYE

Nucleotide

• Length: 264 bp

>T235913 NZ_LR134485:4544131-4544409 [Citrobacter youngae]
ATGAATAAGCTTACTCAGTACGATCCCGCTGCTGCGCTAGTTGATGATGAAGAAATTGCTGTATTTATGGCGGATGCCCT
CGAAACAGGCGATGCAACGTACATTGCAAAAGCGTTGGGCGTGGTGGCACGCGCTAAGGGAATGGCGAACATCGCGGCAG
AAACGGGATTATCCCGCGAACAACTCTATCGCTCGTTTAGTGAGAAAGGAAACCCGACGCTGAAAACCACGCTGGCGGTG
ATGAAGGCGCTCGGTATTGGATTGACACTTAGAAAATAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9157.32 Da
• Isoelectric Point: 4.1317

>AT235913 WP_249006760.1 NZ_CP092289:c4565333-4565091 [Marinobacter sp. M1C]
MTGITATEARSNLYRLIDETAESHQPIVIMGKRNRAVLVSEEDWSAIQETLYLLSVPGMRESIREGMETPMDQCDEELNW

Nucleotide

• Length: 243 bp

>AT235913 NZ_LR134485:4543821-4544138 [Citrobacter youngae]
ATCATGGAAATTCTTCAGACCACGGTTTTCCAACGCTGGGAGCAGAACCTACGGGATCGCAGGGCCAAAACGCTCATTGC
CGCACGACTTTTTCGACTGGCGAATGGTTTAGCTGGCGATGTTAAACCTGTAGGTGAAGGCATCAGCGAAATGCGCATTT
CTTACGGTCCTGGTTACAGGATTTACTTTAAACAGCATGGCTGCCGCATCATCATTTTGCTATGTGGTGGCGATAAAAGC
TCACAAGCTAACAATATCACCCTTGCAAAAGTGCTCGCCCGTTCACTGGACTATCAGGAGACATTCCGCCATGAATAA