Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YefM
Location 4550753..4551333 Replicon chromosome
Accession NZ_CP092289
Organism Marinobacter sp. M1C

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MIH19_RS21470 Protein ID WP_249006798.1
Coordinates 4550753..4551055 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MIH19_RS21475 Protein ID WP_249006799.1
Coordinates 4551052..4551333 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIH19_RS21425 (MIH19_21425) 4546637..4546861 + 225 Protein_4228 transposase domain-containing protein -
MIH19_RS21430 (MIH19_21430) 4547019..4547336 - 318 WP_249006791.1 antibiotic biosynthesis monooxygenase -
MIH19_RS21435 (MIH19_21435) 4547450..4547776 - 327 WP_249006792.1 antibiotic biosynthesis monooxygenase -
MIH19_RS21440 (MIH19_21440) 4547870..4548190 - 321 WP_249006793.1 hypothetical protein -
MIH19_RS21445 (MIH19_21445) 4548337..4548588 + 252 WP_012137510.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
MIH19_RS21450 (MIH19_21450) 4548585..4548839 + 255 WP_249006794.1 Txe/YoeB family addiction module toxin -
MIH19_RS21455 (MIH19_21455) 4549060..4549251 - 192 WP_249006795.1 hypothetical protein -
MIH19_RS21460 (MIH19_21460) 4549345..4549569 + 225 WP_249006796.1 hypothetical protein -
MIH19_RS21465 (MIH19_21465) 4549747..4550649 - 903 WP_249006797.1 hypothetical protein -
MIH19_RS21470 (MIH19_21470) 4550753..4551055 - 303 WP_249006798.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MIH19_RS21475 (MIH19_21475) 4551052..4551333 - 282 WP_249006799.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MIH19_RS21480 (MIH19_21480) 4551498..4551785 - 288 WP_249008970.1 HigA family addiction module antitoxin -
MIH19_RS21485 (MIH19_21485) 4551796..4552074 - 279 WP_249006800.1 type II toxin-antitoxin system RelE/ParE family toxin -
MIH19_RS21490 (MIH19_21490) 4552192..4552815 - 624 WP_249006774.1 SagB/ThcOx family dehydrogenase -
MIH19_RS21495 (MIH19_21495) 4552894..4553472 - 579 WP_249006775.1 TetR/AcrR family transcriptional regulator -
MIH19_RS21500 (MIH19_21500) 4553572..4554054 + 483 WP_249018609.1 HPP family protein -
MIH19_RS21505 (MIH19_21505) 4554366..4554908 - 543 WP_249006801.1 DinB family protein -
MIH19_RS21510 (MIH19_21510) 4554997..4555290 - 294 WP_249006802.1 type II toxin-antitoxin system RelE/ParE family toxin -
MIH19_RS21515 (MIH19_21515) 4555287..4555661 - 375 WP_249006803.1 addiction module protein -
MIH19_RS21520 (MIH19_21520) 4555857..4556324 - 468 WP_249006804.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 4546938..4551785 4847
- inside Integron - - 4555287..4568836 13549
- inside Genomic island - - 4519370..4567768 48398


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-74)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11496.18 Da        Isoelectric Point: 4.6583

>T235911 WP_249006798.1 NZ_CP092289:c4551055-4550753 [Marinobacter sp. M1C]
MKIIWSPLALERIEDISRYIAEDNPDAALQWVNDLFATVERLADFPKSGRMVPEVGAPRIRELIFGTYRVIYSVKDQVNI
LTVRRSSQLLRMSEVGDDET

Download         Length: 303 bp

>T235911 NZ_LR134485:c4442636-4442334 [Citrobacter youngae]
ATGTCTAAATCATTAAATATCAGGAGCTTTCGGGATACATGGCTTGAAGATTTTTTTGAGCGGGCGACATCGCACAGAAA
AATACCAGCGGATATTCATACTGCATTAGCCAGAAAGCTGGATATCATTAATGCGGCTGTTTCGCATCGGGATTTGCGCT
CGCCACCCGGTAACAGATATGAAGAGTTAACCGGAAAATTACAGGAATATTCTTCAATCAGAGTAAACAAGCAGTACCGA
TTAATATTTAAATGGGTTAACGGTAAGGCCGAAGATGTGTACTTAGATCCACACATCTACTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10633.15 Da        Isoelectric Point: 6.7300

>AT235911 WP_249006799.1 NZ_CP092289:c4551333-4551052 [Marinobacter sp. M1C]
MSRVRVDEDIRPLSEFRAGVATFVKQLHETRRPMVLTQRGRGVAVLLGVHEYERMQERLEMLEEVYKAEEQIASGDGVAH
EDAKARVLSRLGQ

Download         Length: 282 bp

>AT235911 NZ_LR134485:c4442307-4441966 [Citrobacter youngae]
ATGAAACAGGCAACCAGAAAACCAACGACTGTGGGTGATATCCTGCAATATGAATACCTGGAGCCGCTCGAACTGAAAAT
TAACGATCTGGCTGAAATACTGCATGTTCATCGCAATACGGTGAGCGCACTGGTCAACAATAACCGCAAATTAACAACGG
ATATGGCGTTTCGTTTGGCCAAAGCGTTCGATACCTCCGTTGATTTCTGGCGTAACTTACAGGCGGCGGTTGACCTGTGG
GAAGTTGAAAATGACATGCGGGCGCAAGAAGAACTGAACCGCATTGTTTCGGTTAAAGATTTTATCGCTCAGCGAAATAG
CGAGTCTAAAAAAGTCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References