Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yoeB-relB/YoeB-YefM |
| Location | 4548337..4548839 | Replicon | chromosome |
| Accession | NZ_CP092289 | ||
| Organism | Marinobacter sp. M1C | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | - |
| Locus tag | MIH19_RS21450 | Protein ID | WP_249006794.1 |
| Coordinates | 4548585..4548839 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | R8B220 |
| Locus tag | MIH19_RS21445 | Protein ID | WP_012137510.1 |
| Coordinates | 4548337..4548588 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MIH19_RS21415 (MIH19_21415) | 4544253..4545197 | - | 945 | WP_249005995.1 | tyrosine-type recombinase/integrase | - |
| MIH19_RS21420 (MIH19_21420) | 4545194..4546456 | - | 1263 | WP_249005994.1 | site-specific integrase | - |
| MIH19_RS21425 (MIH19_21425) | 4546637..4546861 | + | 225 | Protein_4228 | transposase domain-containing protein | - |
| MIH19_RS21430 (MIH19_21430) | 4547019..4547336 | - | 318 | WP_249006791.1 | antibiotic biosynthesis monooxygenase | - |
| MIH19_RS21435 (MIH19_21435) | 4547450..4547776 | - | 327 | WP_249006792.1 | antibiotic biosynthesis monooxygenase | - |
| MIH19_RS21440 (MIH19_21440) | 4547870..4548190 | - | 321 | WP_249006793.1 | hypothetical protein | - |
| MIH19_RS21445 (MIH19_21445) | 4548337..4548588 | + | 252 | WP_012137510.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| MIH19_RS21450 (MIH19_21450) | 4548585..4548839 | + | 255 | WP_249006794.1 | Txe/YoeB family addiction module toxin | Toxin |
| MIH19_RS21455 (MIH19_21455) | 4549060..4549251 | - | 192 | WP_249006795.1 | hypothetical protein | - |
| MIH19_RS21460 (MIH19_21460) | 4549345..4549569 | + | 225 | WP_249006796.1 | hypothetical protein | - |
| MIH19_RS21465 (MIH19_21465) | 4549747..4550649 | - | 903 | WP_249006797.1 | hypothetical protein | - |
| MIH19_RS21470 (MIH19_21470) | 4550753..4551055 | - | 303 | WP_249006798.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| MIH19_RS21475 (MIH19_21475) | 4551052..4551333 | - | 282 | WP_249006799.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| MIH19_RS21480 (MIH19_21480) | 4551498..4551785 | - | 288 | WP_249008970.1 | HigA family addiction module antitoxin | - |
| MIH19_RS21485 (MIH19_21485) | 4551796..4552074 | - | 279 | WP_249006800.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| MIH19_RS21490 (MIH19_21490) | 4552192..4552815 | - | 624 | WP_249006774.1 | SagB/ThcOx family dehydrogenase | - |
| MIH19_RS21495 (MIH19_21495) | 4552894..4553472 | - | 579 | WP_249006775.1 | TetR/AcrR family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4519370..4567768 | 48398 | |
| - | inside | Integron | - | - | 4546938..4551785 | 4847 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10239.80 Da Isoelectric Point: 9.8162
>T235910 WP_249006794.1 NZ_CP092289:4548585-4548839 [Marinobacter sp. M1C]
MKLIFSENAWEDYLYWQKTDKKALNRINKLIKETKREPFEGVGKPEPLKHNLAGYWSRRINEEHRIVYKVTDDALLMAQL
RYHY
MKLIFSENAWEDYLYWQKTDKKALNRINKLIKETKREPFEGVGKPEPLKHNLAGYWSRRINEEHRIVYKVTDDALLMAQL
RYHY
Download Length: 255 bp
>T235910 NZ_LR134485:c4287708-4287424 [Citrobacter youngae]
ATGACTTATGAACTGGAATTCGACCCGAGAGCCTTAAAAGAGTGGCATAAACTGGGTGATACGGTGAAGGCTCAGTTTAA
GAAGAAGTTGGCCGACGTGTTGTTGAACCCCAGAATTGACTCTGCCCGTTTAAACGGTCTTCCAGATTGCTATAAAATTA
AGCTTAAATCGTCCGGCTATCGTCTGGTGTACCAGGTTCGGGATGAGGTTGTGACCGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCGGCCGTTTATCTCGATGCAAACAAACGGCTTTAG
ATGACTTATGAACTGGAATTCGACCCGAGAGCCTTAAAAGAGTGGCATAAACTGGGTGATACGGTGAAGGCTCAGTTTAA
GAAGAAGTTGGCCGACGTGTTGTTGAACCCCAGAATTGACTCTGCCCGTTTAAACGGTCTTCCAGATTGCTATAAAATTA
AGCTTAAATCGTCCGGCTATCGTCTGGTGTACCAGGTTCGGGATGAGGTTGTGACCGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCGGCCGTTTATCTCGATGCAAACAAACGGCTTTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9269.50 Da Isoelectric Point: 4.4750
>AT235910 WP_012137510.1 NZ_CP092289:4548337-4548588 [Marinobacter sp. M1C]
MDAISYTAARTNLAKTMEQVCEDHSPVIITRSKSQSVVMISLEDYEALQETAYLLRAPKNARRLLESVAELEQGGGQEKE
LLE
MDAISYTAARTNLAKTMEQVCEDHSPVIITRSKSQSVVMISLEDYEALQETAYLLRAPKNARRLLESVAELEQGGGQEKE
LLE
Download Length: 252 bp
>AT235910 NZ_LR134485:c4287940-4287698 [Citrobacter youngae]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCTGTGCGATTACTGTTTCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACCGTTAGCGACA
GCGAAGATACACTGATTCAGACAGTCCGGGAGAGGCTGGCCAGCCCGCAAAAAGGAATCAAGGTTAGTCTGGATGACTTA
TGA
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCTGTGCGATTACTGTTTCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACCGTTAGCGACA
GCGAAGATACACTGATTCAGACAGTCCGGGAGAGGCTGGCCAGCCCGCAAAAAGGAATCAAGGTTAGTCTGGATGACTTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|