Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpA-brnA/BrnT-BrnA
Location 3611274..3611766 Replicon chromosome
Accession NZ_CP092289
Organism Marinobacter sp. M1C

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag MIH19_RS17010 Protein ID WP_249006001.1
Coordinates 3611503..3611766 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID -
Locus tag MIH19_RS17005 Protein ID WP_249006000.1
Coordinates 3611274..3611519 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIH19_RS16975 (MIH19_16975) 3606401..3607663 + 1263 WP_249005994.1 site-specific integrase -
MIH19_RS16980 (MIH19_16980) 3607660..3608604 + 945 WP_249005995.1 tyrosine-type recombinase/integrase -
MIH19_RS16985 (MIH19_16985) 3608601..3609608 + 1008 WP_249005996.1 tyrosine-type recombinase/integrase -
MIH19_RS16990 (MIH19_16990) 3609896..3610447 - 552 WP_249005997.1 hypothetical protein -
MIH19_RS16995 (MIH19_16995) 3610449..3610814 - 366 WP_249005998.1 hypothetical protein -
MIH19_RS17000 (MIH19_17000) 3610814..3611005 - 192 WP_249005999.1 hypothetical protein -
MIH19_RS17005 (MIH19_17005) 3611274..3611519 - 246 WP_249006000.1 BrnA antitoxin family protein Antitoxin
MIH19_RS17010 (MIH19_17010) 3611503..3611766 - 264 WP_249006001.1 BrnT family toxin Toxin
MIH19_RS17015 (MIH19_17015) 3612019..3612279 - 261 WP_249006002.1 helix-turn-helix transcriptional regulator -
MIH19_RS17020 (MIH19_17020) 3612936..3613481 - 546 WP_249006003.1 hypothetical protein -
MIH19_RS17025 (MIH19_17025) 3613483..3615705 - 2223 WP_249006004.1 hypothetical protein -
MIH19_RS17030 (MIH19_17030) 3615866..3615973 - 108 WP_249006005.1 hypothetical protein -
MIH19_RS17035 (MIH19_17035) 3616099..3616545 + 447 Protein_3351 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3598878..3625996 27118


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-79)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(13-77)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10262.61 Da        Isoelectric Point: 5.8898

>T235907 WP_249006001.1 NZ_CP092289:c3611766-3611503 [Marinobacter sp. M1C]
MEIEFDNAKSERNMELRGLSFELAAKFDFDGAIEVEQEVNGEQRYFALGHIGSRLYALVYTLRTNIVRVISLRKANKREV
RRYEQFD

Download         Length: 264 bp

>T235907 NZ_LR134485:1785545-1785877 [Citrobacter youngae]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCCGGTCACGAGCAAAGTGGAAAACGTCCGGTGCTTAT
CGTATCGAAGGCATCGTTTAACAAGCTGACCCAGCTACCCGTTGTTGTTCCCGTCACCAGCGGTGGAAACTTTGCCCGTG
CAGCCGGTTTTACTGTCTCCCTGGACGGCGCGGGAACAAAAACAACGGGCGTTATTCGCTGCGACCAGCCCAGAACAATT
GATATGGGTGCCCGGAACGGTAAGCGACTGGAACGCATACCCGATGCTGTCGTGAATGAAGTGCTGGCCCGACTGGAAGC
CATTCTGAGCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9245.24 Da        Isoelectric Point: 7.2038

>AT235907 WP_249006000.1 NZ_CP092289:c3611519-3611274 [Marinobacter sp. M1C]
MSNSIDPEMTDTDNPEWSDTMFAQAKRGTAARRVGRPKLRSPKHSTTLRIDEDVIEFFKSGGSGWQTRMNEALRQYVSEH
S

Download         Length: 246 bp

>AT235907 NZ_LR134485:1785287-1785544 [Citrobacter youngae]
ATGTATACCACTCGCCTGAAAAAGGTTGGCGGATCCGTCATGCTGGCGGTTCCTCCTGCCGTGCTGAAAACTCTTGGGCT
GTCAACCGACAGCGACGTGGGCATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGCTATTCGC
TTGAGGAACTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References