Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-XRE
Location 2882453..2884104 Replicon chromosome
Accession NZ_CP092289
Organism Marinobacter sp. M1C

Toxin (Protein)


Gene name HipA3 Uniprot ID -
Locus tag MIH19_RS13530 Protein ID WP_249005373.1
Coordinates 2882453..2883766 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID -
Locus tag MIH19_RS13535 Protein ID WP_249005374.1
Coordinates 2883763..2884104 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIH19_RS13505 (MIH19_13505) 2877709..2879481 + 1773 WP_249005369.1 SLC13 family permease -
MIH19_RS13510 (MIH19_13510) 2879616..2879894 + 279 WP_249005370.1 XRE family transcriptional regulator -
MIH19_RS13515 (MIH19_13515) 2879891..2881186 + 1296 WP_249005371.1 type II toxin-antitoxin system HipA family toxin -
MIH19_RS13520 (MIH19_13520) 2881255..2881644 - 390 WP_249009006.1 helix-turn-helix transcriptional regulator -
MIH19_RS13525 (MIH19_13525) 2881763..2882404 + 642 WP_249005372.1 transposase -
MIH19_RS13530 (MIH19_13530) 2882453..2883766 - 1314 WP_249005373.1 type II toxin-antitoxin system HipA family toxin Toxin
MIH19_RS13535 (MIH19_13535) 2883763..2884104 - 342 WP_249005374.1 helix-turn-helix transcriptional regulator Antitoxin
MIH19_RS13540 (MIH19_13540) 2884453..2884620 - 168 Protein_2651 MerR family transcriptional regulator -
MIH19_RS13545 (MIH19_13545) 2884812..2885297 - 486 WP_249005375.1 hypothetical protein -
MIH19_RS13550 (MIH19_13550) 2885294..2885593 - 300 WP_249005376.1 nucleotidyltransferase domain-containing protein -
MIH19_RS13555 (MIH19_13555) 2885656..2885847 - 192 WP_249005377.1 hypothetical protein -
MIH19_RS13560 (MIH19_13560) 2885966..2886316 - 351 WP_249005378.1 MerR family transcriptional regulator -
MIH19_RS13565 (MIH19_13565) 2886462..2886764 - 303 WP_249005379.1 integration host factor subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-116)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-67)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 48949.07 Da        Isoelectric Point: 6.2499

>T235906 WP_249005373.1 NZ_CP092289:c2883766-2882453 [Marinobacter sp. M1C]
VSTVTEVILWGKSVGALLYDTETGLSTFEYDKGWLKQDVSISPLHLPPRAGRFNFPSLPQETFFGLPGVFADTLPDDFGN
AVINAWLARQGIPKSSFSPVDRLLYTGNRGMGALEYKPDGRNTQTQVSGDIKVDTLVELAQSVLDQRAGLDVAISEGDEN
NDAMSAIFQVGTSAGGARPKAVIAVNRDRSRVVSGQTPIPKGFTHYLIKFDGVKERSSTSEVFGDPQGYGRMEYAYYLMA
KDAGINMAPSELLIEGERAHFMTQRFDRDGDRKRHYQSLCAMDHADFRKPGQYSYEELMTIARTLGLPRVDAIEIFRRMV
FNVIARNQDDHTKNFGFLLDHSTAGWRLAPAFDIAYSYKPGSYWVDTHQMTINGKRDKFTRGDILAVATQIPRFESNARA
IIDQVTEVVNQWQDYARRADVHSELSQEIYSNLRLSL

Download         Length: 1314 bp

>T235906 NZ_LR134485:c1124749-1124420 [Citrobacter youngae]
ATGAAAACTCTACCTGCTACAATTTCTCGGGCGGCGAAGCCTTGTCTGTCGCCCGTTGCAGTCTGGCAAATGCTTCTTAC
ACGGCTACTGGAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTCTGGGATCAAACTGTTATTAAGGAACATATTG
ATGCAGGGATCACCCTGGCCGATGCAGTCAACTTTCTGGTGGATAAGTACGAACTAGTTCGTATCGACCGGAAGGGATTT
TCGTGGCAAGAGCAGACCCCGTATCTTTCCGTAGTGGATATTCTGCGAGCAAGGCGCTCTACCGGATTGCTAAAAGCCAA
GGTGAAATAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12460.37 Da        Isoelectric Point: 10.0404

>AT235906 WP_249005374.1 NZ_CP092289:c2884104-2883763 [Marinobacter sp. M1C]
MSQIKRSMSDLAILDELGRRLKQARLEQNITQQQIAEGMGVSRATYIRLEDGNGKLEVLVAALRVLGKLPALDAFLPDEP
YSPIAALKSAGHIRQRARPGNKPVEQDKGDLGW

Download         Length: 342 bp

>AT235906 NZ_LR134485:c1125087-1124770 [Citrobacter youngae]
ATGAACAACACCACATGGGGTCTGCAGCGGGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCGGCT
GCACTATCTGGCTGACCGGGCAAGTATCACCGGTAAGTTTAGTGATGCCGAATGCCTGAAGTTGGATGTCGCATTCCCGC
ATTTTATCAGTCAGATGGAATCAATGCTGACTACTGGTGAAATGAATCCTCGCCATGCCCACTGTGTCACTCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACCCTTGGTAGTTGCGGCTACGTATATATCGCCATTTATCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References