Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpA-brnA/BrnT_toxin-BrnA
Location 1114591..1115101 Replicon chromosome
Accession NZ_CP092289
Organism Marinobacter sp. M1C

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag MIH19_RS05400 Protein ID WP_249007892.1
Coordinates 1114591..1114863 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID -
Locus tag MIH19_RS05405 Protein ID WP_249007893.1
Coordinates 1114847..1115101 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIH19_RS05380 (MIH19_05380) 1110307..1111707 + 1401 WP_249007888.1 threonine synthase -
MIH19_RS05385 (MIH19_05385) 1111713..1113443 + 1731 WP_249007889.1 single-stranded-DNA-specific exonuclease RecJ -
MIH19_RS05390 (MIH19_05390) 1113509..1113844 - 336 WP_249007890.1 putative addiction module antidote protein -
MIH19_RS05395 (MIH19_05395) 1113857..1114153 - 297 WP_249007891.1 type II toxin-antitoxin system RelE/ParE family toxin -
MIH19_RS05400 (MIH19_05400) 1114591..1114863 + 273 WP_249007892.1 BrnT family toxin Toxin
MIH19_RS05405 (MIH19_05405) 1114847..1115101 + 255 WP_249007893.1 BrnA antitoxin family protein Antitoxin
MIH19_RS05410 (MIH19_05410) 1115160..1116569 + 1410 WP_249007894.1 plasmid pRiA4b ORF-3 family protein -
MIH19_RS05415 (MIH19_05415) 1116721..1116987 + 267 WP_249007895.1 type II toxin-antitoxin system HicA family toxin -
MIH19_RS05420 (MIH19_05420) 1116984..1117325 + 342 WP_249007896.1 type II toxin-antitoxin system HicB family antitoxin -
MIH19_RS05425 (MIH19_05425) 1117460..1119607 - 2148 WP_249007897.1 flagellin -
MIH19_RS05430 (MIH19_05430) 1119776..1120030 + 255 WP_249007898.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-82)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-77)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10694.23 Da        Isoelectric Point: 5.7237

>T235902 WP_249007892.1 NZ_CP092289:1114591-1114863 [Marinobacter sp. M1C]
MYFEWDDSKNAANISKHGIDFRDAIDMFNHPMLTAIDECFMYGEERWTAIGLMREMVGVVVYTERRESVVRIISARKATR
REVRLYEQNI

Download         Length: 273 bp

>T235902 NZ_LR134482:840461-840814 [Pseudomonas stutzeri]
ATGACTTGGGACGTTGAGTACACCGATGAGTTTGGTGACTGGTGGGAGTCACTCACTGCGGACGAGCAGGAGTCCATAGC
GGTCTCCGTGCATTTGCTGGAAGACCGTGGGCCGTCGCTCGGATTCCCACATAGCAGCGCTATCAATGGGTCACGTCATG
GTCATATGCGAGAGCTGAGAACCCAGCACAACGGGCGCCCGATACGAACGCTGTATGCATTCGATCCCAGGCGCTCGGCG
ATCCTGCTGATTGGCGGAGACAAGACGGGCGACAACCGCTGGTATGAAATCAACGTTCCGTTGGCAGATCGTCTCTATGA
CGAGCACCTGGAACAGCTTGAGAAGGAGGGCTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9964.32 Da        Isoelectric Point: 5.8560

>AT235902 WP_249007893.1 NZ_CP092289:1114847-1115101 [Marinobacter sp. M1C]
MSKTSKTDWKRLTEMEDDAIDTSDISELDDKFFQNAELLIPTKQPVTLRIDEDVLVWFKAQGRGYQTRINKLLRHYMESQ
VTKR

Download         Length: 255 bp

>AT235902 NZ_LR134482:840818-841147 [Pseudomonas stutzeri]
ATGGCCAAGAAATTCGCAGACTTGCGCGCAAAGATGTCGCCAGAGGCTCAGGCTCGCGTGGAAGCCAAAGCCCAGGAGCT
GCTTGCTGAAATGCCGCTGAACGAACTGCGCCAGGCGCGTGGCTTGTCGCAGAAAATGCTAGCCGAGCTACTGCACGTGC
AGCAGCCGTCGATCGCGAAAATGGAAAAGCGCACCGACATGTATATCTCCACGCTGCGTAGCCACATCGAAGCAATGGGC
GGGCAGCTCGAGGTCATCGCCCGATTCCCAGATGGTTCGGTGAAGATCAGCAACTTCGCCGAGATCGAAGCTGCCGCTCA
GCAGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References