Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1040577..1041231 | Replicon | chromosome |
| Accession | NZ_CP092289 | ||
| Organism | Marinobacter sp. M1C | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | MIH19_RS04965 | Protein ID | WP_249007818.1 |
| Coordinates | 1041049..1041231 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | MIH19_RS04960 | Protein ID | WP_249007817.1 |
| Coordinates | 1040577..1041008 (-) | Length | 144 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MIH19_RS04925 (MIH19_04925) | 1035734..1036582 | - | 849 | WP_249007814.1 | glycosyltransferase family 2 protein | - |
| MIH19_RS04930 (MIH19_04930) | 1036603..1038573 | - | 1971 | WP_249007815.1 | hypothetical protein | - |
| MIH19_RS04935 (MIH19_04935) | 1038623..1039051 | - | 429 | WP_283164097.1 | pilin | - |
| MIH19_RS04945 (MIH19_04945) | 1039286..1039720 | - | 435 | WP_283164098.1 | pilin | - |
| MIH19_RS04955 (MIH19_04955) | 1040088..1040324 | - | 237 | WP_249007816.1 | hypothetical protein | - |
| MIH19_RS04960 (MIH19_04960) | 1040577..1041008 | - | 432 | WP_249007817.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| MIH19_RS04965 (MIH19_04965) | 1041049..1041231 | - | 183 | WP_249007818.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| MIH19_RS04970 (MIH19_04970) | 1041336..1041878 | - | 543 | WP_249007819.1 | hypothetical protein | - |
| MIH19_RS04975 (MIH19_04975) | 1042013..1042279 | + | 267 | WP_249007820.1 | YlcI/YnfO family protein | - |
| MIH19_RS04980 (MIH19_04980) | 1042276..1042575 | + | 300 | WP_249007821.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| MIH19_RS04985 (MIH19_04985) | 1042605..1042928 | + | 324 | Protein_971 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| MIH19_RS04990 (MIH19_04990) | 1042930..1043232 | + | 303 | WP_249007822.1 | XRE family transcriptional regulator | - |
| MIH19_RS04995 (MIH19_04995) | 1043350..1043730 | + | 381 | WP_249007823.1 | helix-turn-helix transcriptional regulator | - |
| MIH19_RS05000 (MIH19_05000) | 1043762..1043881 | - | 120 | Protein_974 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| MIH19_RS05005 (MIH19_05005) | 1044024..1044212 | + | 189 | Protein_975 | ATP-binding protein | - |
| MIH19_RS05010 (MIH19_05010) | 1044322..1044795 | - | 474 | WP_249007824.1 | outer membrane protein assembly factor BamE | - |
| MIH19_RS05015 (MIH19_05015) | 1045059..1045331 | - | 273 | WP_249007825.1 | type II toxin-antitoxin system YafQ family toxin | - |
| MIH19_RS05020 (MIH19_05020) | 1045331..1045588 | - | 258 | WP_249007826.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1030151..1052171 | 22020 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6849.86 Da Isoelectric Point: 10.6217
>T235898 WP_249007818.1 NZ_CP092289:c1041231-1041049 [Marinobacter sp. M1C]
VTSDEVKKKLEKDGWELVRVNGSHHHFKHSTKPGLVTLPHPKSELPKGTLNNIWKQAGWK
VTSDEVKKKLEKDGWELVRVNGSHHHFKHSTKPGLVTLPHPKSELPKGTLNNIWKQAGWK
Download Length: 183 bp
>T235898 NZ_LR134480:1809877-1810188 [Bordetella bronchiseptica]
ATGGAGTTCATCGAAACCCCAATTTTCACGCAATTGATCACCGCGTTGCTGTCGGATGAGGAATATTCCAGGCTGCAACA
GCTGCTGATCGACAACCCCGAAAGGGGCGATCTGCTGCGTGGGGGCGGCGGTATACGAAAGATGCGTTACGGCCGGCAAG
GCACGGGCAAGCGAGGTGGCATCCGGGTCATTTATTACTGGATCAGCCAGGATTGTCAGATCTACATGCTTGCGGCTTAT
GCAAAGTCGAAGAAGATCAACCTGACCCCGGACGAAATCGCGGCGCTGCGCGAACTGGTCAAGGAGCTGTAA
ATGGAGTTCATCGAAACCCCAATTTTCACGCAATTGATCACCGCGTTGCTGTCGGATGAGGAATATTCCAGGCTGCAACA
GCTGCTGATCGACAACCCCGAAAGGGGCGATCTGCTGCGTGGGGGCGGCGGTATACGAAAGATGCGTTACGGCCGGCAAG
GCACGGGCAAGCGAGGTGGCATCCGGGTCATTTATTACTGGATCAGCCAGGATTGTCAGATCTACATGCTTGCGGCTTAT
GCAAAGTCGAAGAAGATCAACCTGACCCCGGACGAAATCGCGGCGCTGCGCGAACTGGTCAAGGAGCTGTAA
Antitoxin
Download Length: 144 a.a. Molecular weight: 15809.86 Da Isoelectric Point: 5.6123
>AT235898 WP_249007817.1 NZ_CP092289:c1041008-1040577 [Marinobacter sp. M1C]
MRFPVALHTDDGKNYGVTVPDIPGCFSAGSNEDKALDNAREAILGHLELLAEFGEDIPTANSIAEHRTNADFEGAVWGFI
EIDVTPLLGKAEKINITVPRLVLRQIDRYVKEHPNEARSRSAFLSEAALERMRKSHDKAKTLA
MRFPVALHTDDGKNYGVTVPDIPGCFSAGSNEDKALDNAREAILGHLELLAEFGEDIPTANSIAEHRTNADFEGAVWGFI
EIDVTPLLGKAEKINITVPRLVLRQIDRYVKEHPNEARSRSAFLSEAALERMRKSHDKAKTLA
Download Length: 432 bp
>AT235898 NZ_LR134480:1810191-1810490 [Bordetella bronchiseptica]
ATGAAAAAAGACAACACGGTGTTCAACGACCTGCAAGCCAGCCTGAAGCAAGCCGTGGCCATTCGCCAAGGCAAGATGCC
GCCATCGCGTGTATTCAAGGTTGAGACTGTGGATGTGAAGGCAACGCGCGAAAAAACGCACATGTCTCAAACGGAATTCG
CCAAAGCCATCCACGTCAGTGTCCGTACGCTGCAGAACTGGGAGCAAGGTCACCGCAATCCGACGGGCCCTGCCGTGGCG
CTTCTGAAAATCGTGGCAAGCGCCCCGGACATTGCCGTGCGAGCGCTGCGGACCGCGTAA
ATGAAAAAAGACAACACGGTGTTCAACGACCTGCAAGCCAGCCTGAAGCAAGCCGTGGCCATTCGCCAAGGCAAGATGCC
GCCATCGCGTGTATTCAAGGTTGAGACTGTGGATGTGAAGGCAACGCGCGAAAAAACGCACATGTCTCAAACGGAATTCG
CCAAAGCCATCCACGTCAGTGTCCGTACGCTGCAGAACTGGGAGCAAGGTCACCGCAATCCGACGGGCCCTGCCGTGGCG
CTTCTGAAAATCGTGGCAAGCGCCCCGGACATTGCCGTGCGAGCGCTGCGGACCGCGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|