Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 541444..542081 Replicon chromosome
Accession NZ_CP092289
Organism Marinobacter sp. M1C

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag MIH19_RS02525 Protein ID WP_249007417.1
Coordinates 541444..541854 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag MIH19_RS02530 Protein ID WP_249007418.1
Coordinates 541851..542081 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIH19_RS02485 (MIH19_02485) 536788..537015 - 228 WP_249007410.1 transposase -
MIH19_RS02490 (MIH19_02490) 537185..537331 + 147 WP_249007411.1 RRXRR domain-containing protein -
MIH19_RS02495 (MIH19_02495) 537337..538203 + 867 WP_249007412.1 helix-turn-helix domain-containing protein -
MIH19_RS02500 (MIH19_02500) 538583..538765 + 183 WP_249007413.1 stability determinant -
MIH19_RS02505 (MIH19_02505) 538987..539385 + 399 WP_249007414.1 transposase -
MIH19_RS02510 (MIH19_02510) 539382..540473 + 1092 WP_249007415.1 IS3 family transposase -
MIH19_RS02515 (MIH19_02515) 540454..540714 - 261 Protein_501 transposase -
MIH19_RS02520 (MIH19_02520) 540836..541264 - 429 WP_249007416.1 DUF2384 domain-containing protein -
MIH19_RS02525 (MIH19_02525) 541444..541854 - 411 WP_249007417.1 type II toxin-antitoxin system VapC family toxin Toxin
MIH19_RS02530 (MIH19_02530) 541851..542081 - 231 WP_249007418.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MIH19_RS02535 (MIH19_02535) 542475..543749 - 1275 WP_249007419.1 type II toxin-antitoxin system HipA family toxin -
MIH19_RS02540 (MIH19_02540) 543746..544093 - 348 WP_249007420.1 helix-turn-helix domain-containing protein -
MIH19_RS02545 (MIH19_02545) 544505..544747 + 243 WP_249007421.1 hypothetical protein -
MIH19_RS02550 (MIH19_02550) 544888..545127 + 240 WP_249007422.1 hypothetical protein -
MIH19_RS02555 (MIH19_02555) 545129..545320 - 192 WP_249007423.1 hypothetical protein -
MIH19_RS02560 (MIH19_02560) 545396..546151 - 756 WP_249007424.1 IS21-like element helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-128)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15109.29 Da        Isoelectric Point: 6.2208

>T235897 WP_249007417.1 NZ_CP092289:c541854-541444 [Marinobacter sp. M1C]
VTTYMLDTCICSYIMREHPASVLQRLTYEVEQGDRIVISAITYAEMRYGQIGKKASAKHKVLIDEFVERVDAVLSWDQRA
VDATVTAMSQLRKAGTPIGPNDTAIAGHAIATGCTLVTNNVREFSRVPSLVYEDWV

Download         Length: 411 bp

>T235897 NZ_LR134480:629345-629641 [Bordetella bronchiseptica]
ATGGAAAAGGGAACACCGCACTGCAAGCTGCCGGCGCTCAAGGCGCTGGTCCATGCAGGCCAGGTCCGAGCCACGTATTC
CGCCTTGTCCGGCGCGGCGGCGCTGGGGCTGGATTTCAGCGCCATGGTCGAAATCGTGCTTGCACTGACACCGCGGGATT
TCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGGACGTCTATTGCCCAGTGACAGCGATGGGTGCCGTC
TACCTGAAGCTGACGGTCCTCGACGGCGTGCTGATCGTGTCGTTCAAGGAGTTGTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8397.49 Da        Isoelectric Point: 4.9987

>AT235897 WP_249007418.1 NZ_CP092289:c542081-541851 [Marinobacter sp. M1C]
MRTVSIFKNGKNQAVRLPADMAYTGVGELEISRDGDVITLRPVRASWASFADLPKADADFLNERPVVASDESRFNL

Download         Length: 231 bp

>AT235897 NZ_LR134480:629644-630045 [Bordetella bronchiseptica]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACCATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCCGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGTTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCCCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References