Detailed information of TA system TA235896

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/Txe-YefM
• Location: 4564110..4564612
• Replicon: chromosome
• Accession: NZ_CP092288
• Organism: Marinobacter sp. M2C

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: MIH17_RS21580
• Protein ID: WP_249006759.1
• Coordinates: 4564110..4564373 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MIH17_RS21585
• Protein ID: WP_249006760.1
• Coordinates: 4564370..4564612 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MIH17_RS21545 (MIH17_21545)	4559374..4559784	-	411	WP_249006807.1	hypothetical protein	-
MIH17_RS21550 (MIH17_21550)	4559862..4560152	-	291	WP_249006808.1	hypothetical protein	-
MIH17_RS21555 (MIH17_21555)	4560291..4560779	-	489	WP_249006809.1	hypothetical protein	-
MIH17_RS21560 (MIH17_21560)	4560776..4561471	-	696	WP_249006810.1	GNAT family N-acetyltransferase	-
MIH17_RS21565 (MIH17_21565)	4561446..4561751	-	306	WP_217632702.1	chorismate mutase	-
MIH17_RS21570 (MIH17_21570)	4561854..4562531	-	678	WP_249006811.1	HAD family phosphatase	-
MIH17_RS21575 (MIH17_21575)	4562635..4563600	-	966	WP_249006812.1	alcohol dehydrogenase catalytic domain-containing protein	-
MIH17_RS21580 (MIH17_21580)	4564110..4564373	-	264	WP_249006759.1	Txe/YoeB family addiction module toxin	Toxin
MIH17_RS21585 (MIH17_21585)	4564370..4564612	-	243	WP_249006760.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MIH17_RS21590 (MIH17_21590)	4564772..4565332	-	561	WP_249006813.1	hypothetical protein	-
MIH17_RS21595 (MIH17_21595)	4565431..4565748	-	318	WP_249006791.1	antibiotic biosynthesis monooxygenase	-
MIH17_RS21600 (MIH17_21600)	4566264..4566488	+	225	WP_249006796.1	hypothetical protein	-
MIH17_RS21605 (MIH17_21605)	4566682..4567047	-	366	WP_249006787.1	cupin domain-containing protein	-
MIH17_RS21610 (MIH17_21610)	4567279..4568237	+	959	Protein_4264	integron integrase	-
MIH17_RS21615 (MIH17_21615)	4568331..4569389	-	1059	WP_249006814.1	ribonucleotide-diphosphate reductase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4518649..4567047	48398
	-	inside	Integron	-	-	4554566..4568115	13549

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10073.76 Da
• Isoelectric Point: 10.2588

>T235896 WP_249006759.1 NZ_CP092288:c4564373-4564110 [Marinobacter sp. M2C]
VTWKLVYTKQAQKDAKKLAASSLKPKAQGLLALIAEDPYRRPPPFEKLIGDLAGAYSRRINIQHRVVYEVLEDERVVKVL
RLWSHYE

Nucleotide

• Length: 264 bp

>T235896 NZ_LR134479:927693-927953 [Rothia aeria]
GTGAGAATCATATTTGATGATTCAGCATGGAGCGACTATCTCTGGTGGCAGGCTCAGGATCGGAAGGTTCTCAAACGTAT
TAATCTACTCATTAAAGATGTTGAGCGAAACGGTAACGAAGGCATAGGGAAGCCTGAAGCTCTCAGACACCAATTCTCAG
GTTGGTGGTCACGCAGAATTACCGATGAACACCGTCTCGTATACAAGCTTACTGACGACTCTATCGTTATAGCTTCATGC
CGATATCACTATGGAGCCTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9157.32 Da
• Isoelectric Point: 4.1317

>AT235896 WP_249006760.1 NZ_CP092288:c4564612-4564370 [Marinobacter sp. M2C]
MTGITATEARSNLYRLIDETAESHQPIVIMGKRNRAVLVSEEDWSAIQETLYLLSVPGMRESIREGMETPMDQCDEELNW

Nucleotide

• Length: 243 bp

>AT235896 NZ_LR134479:927436-927690 [Rothia aeria]
ATGAAAACCATGTCTTACACTGAGTCTCGGGCTCGGTATGCTGAAGTACTTGATCACGTTGAAGACCACCGCGAAGAAGT
TGTCATCACTCGATCCGGGCATGAGCCTGCAGTTATTCTCTCATTGTCTGAGTACGAATCTCTTCAAGAGACTGCTTACC
TTATGCGTTCCCCGGCTAACGCACGTCGTCTTATGGAGTCTATTTCTCGTCTTGAAGCTGGTCTTGGAACTGAGCAGCAG
CTGATTGAGGAATAG