Detailed information of TA system TA235890

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpA-brnA/BrnT-BrnA
• Location: 3610442..3610934
• Replicon: chromosome
• Accession: NZ_CP092288
• Organism: Marinobacter sp. M2C

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: -
• Locus tag: MIH17_RS16995
• Protein ID: WP_249006001.1
• Coordinates: 3610671..3610934 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: -
• Locus tag: MIH17_RS16990
• Protein ID: WP_249006000.1
• Coordinates: 3610442..3610687 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MIH17_RS16960 (MIH17_16960)	3605569..3606831	+	1263	WP_249005994.1	site-specific integrase	-
MIH17_RS16965 (MIH17_16965)	3606828..3607772	+	945	WP_249005995.1	tyrosine-type recombinase/integrase	-
MIH17_RS16970 (MIH17_16970)	3607769..3608776	+	1008	WP_249005996.1	tyrosine-type recombinase/integrase	-
MIH17_RS16975 (MIH17_16975)	3609064..3609615	-	552	WP_249005997.1	hypothetical protein	-
MIH17_RS16980 (MIH17_16980)	3609617..3609982	-	366	WP_249005998.1	hypothetical protein	-
MIH17_RS16985 (MIH17_16985)	3609982..3610173	-	192	WP_249005999.1	hypothetical protein	-
MIH17_RS16990 (MIH17_16990)	3610442..3610687	-	246	WP_249006000.1	BrnA antitoxin family protein	Antitoxin
MIH17_RS16995 (MIH17_16995)	3610671..3610934	-	264	WP_249006001.1	BrnT family toxin	Toxin
MIH17_RS17000 (MIH17_17000)	3611187..3611447	-	261	WP_249006002.1	helix-turn-helix transcriptional regulator	-
MIH17_RS17005 (MIH17_17005)	3612104..3612649	-	546	WP_249006003.1	hypothetical protein	-
MIH17_RS17010 (MIH17_17010)	3612651..3614873	-	2223	WP_249006004.1	hypothetical protein	-
MIH17_RS17015 (MIH17_17015)	3615034..3615141	-	108	WP_249006005.1	hypothetical protein	-
MIH17_RS17020 (MIH17_17020)	3615267..3615713	+	447	Protein_3347	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3598046..3625164	27118

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-79)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (13-77)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10262.61 Da
• Isoelectric Point: 5.8898

>T235890 WP_249006001.1 NZ_CP092288:c3610934-3610671 [Marinobacter sp. M2C]
MEIEFDNAKSERNMELRGLSFELAAKFDFDGAIEVEQEVNGEQRYFALGHIGSRLYALVYTLRTNIVRVISLRKANKREV
RRYEQFD

Nucleotide

• Length: 264 bp

>T235890 NZ_LR134478:c3940797-3940408 [Serratia plymuthica]
ATGTATATGTTTGACACCAATACCGTGAGCCACCTGTTTCGCCGGCACCCAGGTTTGCTGAGTGCGATGGAAAAGGTGCC
GCCTTCCACCGTATGCATTTCCAGCATCACGGAGGCGGAGCTGCTTTTTGGCGTGGCCAAGCGGCAGAGTAAAGCGTTGA
AAGCCATGGTAACGGCGTTTTTAGCCGCGGTGACCGTTTATGACTGGGATAGCGAAGCTGCCCGCTGTTATGGCGTGATG
CGGGCGAGCATGGAGAAAAAAGGCAAAGTCCTGGGCGCGCTGGACCAGTTGATTGCCGCGCATGCGCTTAGCCGGGGCGC
GACAATGGTCACTAGCGATCGGGCCTTTGGCATGGTGCCTGGGCTGGACGTTGAAGACTGGACCCTATAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9245.24 Da
• Isoelectric Point: 7.2038

>AT235890 WP_249006000.1 NZ_CP092288:c3610687-3610442 [Marinobacter sp. M2C]
MSNSIDPEMTDTDNPEWSDTMFAQAKRGTAARRVGRPKLRSPKHSTTLRIDEDVIEFFKSGGSGWQTRMNEALRQYVSEH
S

Nucleotide

• Length: 246 bp

>AT235890 NZ_LR134478:c3941063-3940800 [Serratia plymuthica]
ATGGAAAGAATCGCAAAGCTGTTTAAAAATGGTAGAAATCAGGCGGTGAGGTTACCCGTGGAATTTGAATTTGACACAGA
TCGTGTGTATATCCGCCGCGATCGGGAGGGGAATGTGATTTTATCGAAATACCCTGCAAAACCGGACAGTTGGGAGCCGT
TGTTGAACATGATCGCCAAAACGCCGGTGCCGCATGATTTTCTGGGCGCGGATGAACGCCAACAAGGCATTGCCGACCGG
GATCCTTTCGCAGAGGAAGAGTAA