Detailed information of TA system TA235889

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-XRE
• Location: 2882843..2884494
• Replicon: chromosome
• Accession: NZ_CP092288
• Organism: Marinobacter sp. M2C

Toxin (Protein)

• Gene name: HipA3
• Uniprot ID: -
• Locus tag: MIH17_RS13525
• Protein ID: WP_249005373.1
• Coordinates: 2882843..2884156 (-)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: HipB3
• Uniprot ID: -
• Locus tag: MIH17_RS13530
• Protein ID: WP_249005374.1
• Coordinates: 2884153..2884494 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MIH17_RS13500 (MIH17_13500)	2878099..2879871	+	1773	WP_249005369.1	SLC13 family permease	-
MIH17_RS13505 (MIH17_13505)	2880006..2880284	+	279	WP_249005370.1	XRE family transcriptional regulator	-
MIH17_RS13510 (MIH17_13510)	2880281..2881576	+	1296	WP_249005371.1	type II toxin-antitoxin system HipA family toxin	-
MIH17_RS13515 (MIH17_13515)	2881645..2882034	-	390	WP_249009006.1	helix-turn-helix transcriptional regulator	-
MIH17_RS13520 (MIH17_13520)	2882153..2882794	+	642	WP_249005372.1	transposase	-
MIH17_RS13525 (MIH17_13525)	2882843..2884156	-	1314	WP_249005373.1	type II toxin-antitoxin system HipA family toxin	Toxin
MIH17_RS13530 (MIH17_13530)	2884153..2884494	-	342	WP_249005374.1	helix-turn-helix transcriptional regulator	Antitoxin
MIH17_RS13535 (MIH17_13535)	2884843..2885010	-	168	Protein_2650	MerR family transcriptional regulator	-
MIH17_RS13540 (MIH17_13540)	2885202..2885687	-	486	WP_249005375.1	hypothetical protein	-
MIH17_RS13545 (MIH17_13545)	2885684..2885983	-	300	WP_249005376.1	nucleotidyltransferase domain-containing protein	-
MIH17_RS13550 (MIH17_13550)	2886046..2886237	-	192	WP_249005377.1	hypothetical protein	-
MIH17_RS13555 (MIH17_13555)	2886356..2886706	-	351	WP_249005378.1	MerR family transcriptional regulator	-
MIH17_RS13560 (MIH17_13560)	2886852..2887154	-	303	WP_249005379.1	integration host factor subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (6-116)

Antitoxin

• Cro/C1-type helix-turn-helix domain (18-67)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 48949.07 Da
• Isoelectric Point: 6.2499

>T235889 WP_249005373.1 NZ_CP092288:c2884156-2882843 [Marinobacter sp. M2C]
VSTVTEVILWGKSVGALLYDTETGLSTFEYDKGWLKQDVSISPLHLPPRAGRFNFPSLPQETFFGLPGVFADTLPDDFGN
AVINAWLARQGIPKSSFSPVDRLLYTGNRGMGALEYKPDGRNTQTQVSGDIKVDTLVELAQSVLDQRAGLDVAISEGDEN
NDAMSAIFQVGTSAGGARPKAVIAVNRDRSRVVSGQTPIPKGFTHYLIKFDGVKERSSTSEVFGDPQGYGRMEYAYYLMA
KDAGINMAPSELLIEGERAHFMTQRFDRDGDRKRHYQSLCAMDHADFRKPGQYSYEELMTIARTLGLPRVDAIEIFRRMV
FNVIARNQDDHTKNFGFLLDHSTAGWRLAPAFDIAYSYKPGSYWVDTHQMTINGKRDKFTRGDILAVATQIPRFESNARA
IIDQVTEVVNQWQDYARRADVHSELSQEIYSNLRLSL

Nucleotide

• Length: 1314 bp

>T235889 NZ_LR134478:c3904578-3904309 [Serratia plymuthica]
ATGCGGATAGAATGGAGTCGTGAAGCTCAGGAAGAGCTATGGAACATTATTGATTATATTGATGATAGAAACCCGCAGGC
TGCGCTCATTTTACAGCGCGGGATCGAAACGGCGGTGCATTCGCTGTCGCTGAATCTCTTTATGTACCGGTTGGGTAGAG
TAGATAACACTCGTGAGATTGTCGTCCATCCCAACTACCTGATTGTTTATAGAATCATCGGACATATAGAAGTTCTTAGT
GTTATTCACGCTAAACGAGAATATCCCTGA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12460.37 Da
• Isoelectric Point: 10.0404

>AT235889 WP_249005374.1 NZ_CP092288:c2884494-2884153 [Marinobacter sp. M2C]
MSQIKRSMSDLAILDELGRRLKQARLEQNITQQQIAEGMGVSRATYIRLEDGNGKLEVLVAALRVLGKLPALDAFLPDEP
YSPIAALKSAGHIRQRARPGNKPVEQDKGDLGW

Nucleotide

• Length: 342 bp

>AT235889 NZ_LR134478:c3904776-3904582 [Serratia plymuthica]
ATGGTGATCAAAACCTCCCTCTCCACCCAGCCCATAGCTGAGGTAGCCGAACAAGGCGAAAGTTACGATCGTTGGTTCCG
GGCCAAGATTGAAGCAGCCACTAACAGCGAAAAGCCAAGAGTTCCGCACGAGCAGGTCATGAACGAGATGCAAATTCGTT
TAGCTGCAAAGAAAAAGATACGCAAAATGGAATGA