Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1042258..1042912 Replicon chromosome
Accession NZ_CP092288
Organism Marinobacter sp. M2C

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag MIH17_RS04970 Protein ID WP_249007818.1
Coordinates 1042730..1042912 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MIH17_RS04965 Protein ID WP_249007817.1
Coordinates 1042258..1042689 (-) Length 144 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIH17_RS04930 (MIH17_04930) 1037415..1038263 - 849 WP_249007814.1 glycosyltransferase family 2 protein -
MIH17_RS04935 (MIH17_04935) 1038284..1040254 - 1971 WP_249007815.1 hypothetical protein -
MIH17_RS04940 (MIH17_04940) 1040304..1040732 - 429 WP_283164097.1 pilin -
MIH17_RS04950 (MIH17_04950) 1040967..1041401 - 435 WP_283164098.1 pilin -
MIH17_RS04960 (MIH17_04960) 1041769..1042005 - 237 WP_249007816.1 hypothetical protein -
MIH17_RS04965 (MIH17_04965) 1042258..1042689 - 432 WP_249007817.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MIH17_RS04970 (MIH17_04970) 1042730..1042912 - 183 WP_249007818.1 type II toxin-antitoxin system HicA family toxin Toxin
MIH17_RS04975 (MIH17_04975) 1043017..1043559 - 543 WP_249007819.1 hypothetical protein -
MIH17_RS04980 (MIH17_04980) 1043694..1043960 + 267 WP_249007820.1 YlcI/YnfO family protein -
MIH17_RS04985 (MIH17_04985) 1043957..1044256 + 300 WP_249007821.1 type II toxin-antitoxin system RelE/ParE family toxin -
MIH17_RS04990 (MIH17_04990) 1044286..1044609 + 324 Protein_972 type II toxin-antitoxin system RelE/ParE family toxin -
MIH17_RS04995 (MIH17_04995) 1044611..1044913 + 303 WP_249007822.1 XRE family transcriptional regulator -
MIH17_RS05000 (MIH17_05000) 1045031..1045411 + 381 WP_249007823.1 helix-turn-helix transcriptional regulator -
MIH17_RS05005 (MIH17_05005) 1045443..1045562 - 120 Protein_975 type II toxin-antitoxin system RelE/ParE family toxin -
MIH17_RS05010 (MIH17_05010) 1045705..1045893 + 189 Protein_976 ATP-binding protein -
MIH17_RS05015 (MIH17_05015) 1046003..1046476 - 474 WP_249007824.1 outer membrane protein assembly factor BamE -
MIH17_RS05020 (MIH17_05020) 1046740..1047012 - 273 WP_249007825.1 type II toxin-antitoxin system YafQ family toxin -
MIH17_RS05025 (MIH17_05025) 1047012..1047269 - 258 WP_249007826.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6849.86 Da        Isoelectric Point: 10.6217

>T235881 WP_249007818.1 NZ_CP092288:c1042912-1042730 [Marinobacter sp. M2C]
VTSDEVKKKLEKDGWELVRVNGSHHHFKHSTKPGLVTLPHPKSELPKGTLNNIWKQAGWK

Download         Length: 183 bp

>T235881 NZ_LR134478:c1127384-1127181 [Serratia plymuthica]
ATGACTAAAATTGACTATCTGATGCGTTTACGTAAATGCACCACGATTGACACCCTGGAACGCGTTATTGAAAAAAATAA
GTATGAGCTTTCGGACGACGAGCTCGAGCTGTTTTACTCCGCAGCAGACCACCGTCTTGCCGAGCTCACCATGAATAAGC
TGTACGATAAAATCCCTGTTGCCGTTTGGAAATTCGTAAGGTAA

Antitoxin


Download         Length: 144 a.a.        Molecular weight: 15809.86 Da        Isoelectric Point: 5.6123

>AT235881 WP_249007817.1 NZ_CP092288:c1042689-1042258 [Marinobacter sp. M2C]
MRFPVALHTDDGKNYGVTVPDIPGCFSAGSNEDKALDNAREAILGHLELLAEFGEDIPTANSIAEHRTNADFEGAVWGFI
EIDVTPLLGKAEKINITVPRLVLRQIDRYVKEHPNEARSRSAFLSEAALERMRKSHDKAKTLA

Download         Length: 432 bp

>AT235881 NZ_LR134478:c1127803-1127435 [Serratia plymuthica]
ATGGATGAGTATTCGCCTAAAAGGCACGATATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTACGATGAAGGTATCGC
CACTCTGGGCGACAGCCACCACGGCTGGGTGAACGATCCAACGTCTTCCGTCAACCTCCAGCTTAACGAGTTGATTGAAC
ATATTGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAAAGTGATTTATCAGAGTTAGTCGAAGAGTATCTC
GACGATACCTACACGCTGTTTAGCAGTTACGGTATTAACGATTCCGATTTGCGCCGCTGGCAAAAAACCAAAGCGCGATT
ATTCAGAATGTTCTCAGGAGAGGGCATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References