Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 9839..10419 Replicon plasmid unnamed2
Accession NZ_CP092286
Organism Marinobacter sp. M3C

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag MIH18_RS23590 Protein ID WP_249014877.1
Coordinates 9839..10027 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MIH18_RS23595 Protein ID WP_249014878.1
Coordinates 10030..10419 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIH18_RS23535 (MIH18_23535) 6264..6473 - 210 WP_249014866.1 hypothetical protein -
MIH18_RS23540 (MIH18_23540) 6473..6700 - 228 WP_249014867.1 hypothetical protein -
MIH18_RS23545 (MIH18_23545) 6694..7335 - 642 WP_249014868.1 HNH endonuclease signature motif containing protein -
MIH18_RS23550 (MIH18_23550) 7339..7572 - 234 WP_249014869.1 hypothetical protein -
MIH18_RS23555 (MIH18_23555) 7562..7783 - 222 WP_249014870.1 hypothetical protein -
MIH18_RS23560 (MIH18_23560) 7815..8243 - 429 WP_249014871.1 hypothetical protein -
MIH18_RS23565 (MIH18_23565) 8240..8425 - 186 WP_249014872.1 carbon storage regulator -
MIH18_RS23570 (MIH18_23570) 8444..8794 - 351 WP_249014873.1 hypothetical protein -
MIH18_RS23575 (MIH18_23575) 8794..9009 - 216 WP_249014874.1 hypothetical protein -
MIH18_RS23580 (MIH18_23580) 9006..9218 - 213 WP_249014875.1 hypothetical protein -
MIH18_RS23585 (MIH18_23585) 9233..9622 - 390 WP_249014876.1 helix-turn-helix transcriptional regulator -
MIH18_RS23590 (MIH18_23590) 9839..10027 + 189 WP_249014877.1 type II toxin-antitoxin system HicA family toxin Toxin
MIH18_RS23595 (MIH18_23595) 10030..10419 + 390 WP_249014878.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MIH18_RS23600 (MIH18_23600) 10554..11006 - 453 WP_249014879.1 hypothetical protein -
MIH18_RS23605 (MIH18_23605) 11040..11570 - 531 WP_249014880.1 hypothetical protein -
MIH18_RS23610 (MIH18_23610) 11614..12486 - 873 WP_249014881.1 hypothetical protein -
MIH18_RS23615 (MIH18_23615) 12483..13232 - 750 WP_249014882.1 hypothetical protein -
MIH18_RS23620 (MIH18_23620) 13239..13793 - 555 WP_249014883.1 helix-turn-helix transcriptional regulator -
MIH18_RS23625 (MIH18_23625) 13806..14045 + 240 WP_249014884.1 YdaS family helix-turn-helix protein -
MIH18_RS23995 14423..14554 - 132 WP_283164909.1 hypothetical protein -
MIH18_RS23630 (MIH18_23630) 14713..14961 + 249 WP_249014885.1 hypothetical protein -
MIH18_RS23635 (MIH18_23635) 14976..15227 + 252 WP_249014886.1 DNA translocase FtsK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..46935 46935


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-123)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7156.36 Da        Isoelectric Point: 10.8998

>T235879 WP_249014877.1 NZ_CP092286:9839-10027 [Marinobacter sp. M3C]
MKSADIIKRLKAEGWVKVGGKGDHEKFKHPEKPGHVVVPHPRKDMPLGTLRSIYRQAGWDWR

Download         Length: 189 bp

>T235879 NZ_LR134478:548421-549371 [Serratia plymuthica]
ATGGATGATTTAACAACGCTATTCCCAGATGTTGCCGATGCTCTGGGCATTGAATCAGTTGCAATTGTAGAGAAAGATTA
TTACATCGTTGAGTTATTGCGATTGCTCCAGCCTCTGGTTTTTGATACGCATCAACTGGTTTTTGCCGGTGGAACGGCAT
TGTCAAAAGCGGGGATATCTTTGAACAGGATGTCGGAGGACGTGGACATTAAGCTTGTCCCTGCCGCCGGTTTTTCCCAG
CAATATTCCAGAGGTCAGCGTAAAAACATCCGTAAGGGTATTATTCAGACCATTATCGAAACGATTGCAGCTTCTGGTAC
GTTTCGCCTGGATGAAGAGTATCCAAAGGTTACTCGTGATGAATATCGCTATAATGAAATTCCGGTACGCTACCCGCAGG
AATATGCACAAATTCCCTGCTTAAGGCCATTTATCAAACTGGAACTAATGGAAACAGATTTGCTTGAGGTTGCGGAAAAC
CGCGCTATTAGTTCATTGGTAATGGATCTAACAAAGAAGGGCGAAGTAGTGGGGGCTTTCCCCTGCGCAACTATCACCAG
CACGCAGGCTGAAAAGCTGATTTCGATGATGCGCAGAACGGCTGCAAGCATGCGTGATGTGGAGCGTGCGGTGGATGAGT
CACTGGTGCGTCATATCTACGACAATTTTTGTATAGTTAGAGAAAAAGGTTCTGACGTTCCTGTTTTGAAGCACTTGGTG
CAGGAATGCATTGAGCAGGATATTGAACGTTACGGTGCCCAGTACCCTGAATTCTGCGAATCGCCTGTTGAAGAGCTGAA
AATGGGGCTGGAAGAACTGGCGAGCAATCCTGTTTATAAGGAACGCTATCTGCACTTTGTTACACCAATGGTATTCGGTA
AAAGCCAGGTTTCCTGGGAAGAGGCCTATATCTGTTTTCGCAAGACGGCATTGGATGTGGTTGATGCATAG

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 14083.94 Da        Isoelectric Point: 4.5927

>AT235879 WP_249014878.1 NZ_CP092286:10030-10419 [Marinobacter sp. M3C]
MLFPVYVHTGDDTHAHGAEVPDFPGCFSAADNWDALAGNIQEAVELHCEDEDMAVPAPTSLGKLMGSPDYQGGIWMMVDI
DTGKLRTKSVRLNVSLPEGLLRRIDDEAKIRHMSRSAFLAMSAQRELGA

Download         Length: 390 bp

>AT235879 NZ_LR134478:548033-548428 [Serratia plymuthica]
ATGACCATAAAAGCTCGTATTCAGTCACGACTGAAACGCTCAAAGCGTTATGTTTTCACTCGTGACGATTTCAAAGATCT
TGCTGGTTACGATCAAATTGGCAGAGCACTGCGTGAACTGGTGAAGGAAGGACAGCTGTTGAAAGTAGGCTATGGCGTCT
ATACCAAAGCGCGGCAAAATGTGATTACCGGCAAGTTGATGCCTGCTGCTCCCGGAGGTTCTGCTGCGGTAGTGATTGAG
GCGTTGGAACGTCTGAACGTGGATTACCGCTTGGTTGGAGCAACAAGCGCCTATAATAGTGGTAAATCCACTCAGATCCC
CGCGTCACTGGAAATCAAAACCTCACCACGTTTTAAGAGAACGTTGTCAGTAGGGAACAGTAAATTAAATGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References