Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA-HicB |
Location | 9839..10419 | Replicon | plasmid unnamed2 |
Accession | NZ_CP092286 | ||
Organism | Marinobacter sp. M3C |
Toxin (Protein)
Gene name | hicA | Uniprot ID | - |
Locus tag | MIH18_RS23590 | Protein ID | WP_249014877.1 |
Coordinates | 9839..10027 (+) | Length | 63 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | - |
Locus tag | MIH18_RS23595 | Protein ID | WP_249014878.1 |
Coordinates | 10030..10419 (+) | Length | 130 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MIH18_RS23535 (MIH18_23535) | 6264..6473 | - | 210 | WP_249014866.1 | hypothetical protein | - |
MIH18_RS23540 (MIH18_23540) | 6473..6700 | - | 228 | WP_249014867.1 | hypothetical protein | - |
MIH18_RS23545 (MIH18_23545) | 6694..7335 | - | 642 | WP_249014868.1 | HNH endonuclease signature motif containing protein | - |
MIH18_RS23550 (MIH18_23550) | 7339..7572 | - | 234 | WP_249014869.1 | hypothetical protein | - |
MIH18_RS23555 (MIH18_23555) | 7562..7783 | - | 222 | WP_249014870.1 | hypothetical protein | - |
MIH18_RS23560 (MIH18_23560) | 7815..8243 | - | 429 | WP_249014871.1 | hypothetical protein | - |
MIH18_RS23565 (MIH18_23565) | 8240..8425 | - | 186 | WP_249014872.1 | carbon storage regulator | - |
MIH18_RS23570 (MIH18_23570) | 8444..8794 | - | 351 | WP_249014873.1 | hypothetical protein | - |
MIH18_RS23575 (MIH18_23575) | 8794..9009 | - | 216 | WP_249014874.1 | hypothetical protein | - |
MIH18_RS23580 (MIH18_23580) | 9006..9218 | - | 213 | WP_249014875.1 | hypothetical protein | - |
MIH18_RS23585 (MIH18_23585) | 9233..9622 | - | 390 | WP_249014876.1 | helix-turn-helix transcriptional regulator | - |
MIH18_RS23590 (MIH18_23590) | 9839..10027 | + | 189 | WP_249014877.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
MIH18_RS23595 (MIH18_23595) | 10030..10419 | + | 390 | WP_249014878.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
MIH18_RS23600 (MIH18_23600) | 10554..11006 | - | 453 | WP_249014879.1 | hypothetical protein | - |
MIH18_RS23605 (MIH18_23605) | 11040..11570 | - | 531 | WP_249014880.1 | hypothetical protein | - |
MIH18_RS23610 (MIH18_23610) | 11614..12486 | - | 873 | WP_249014881.1 | hypothetical protein | - |
MIH18_RS23615 (MIH18_23615) | 12483..13232 | - | 750 | WP_249014882.1 | hypothetical protein | - |
MIH18_RS23620 (MIH18_23620) | 13239..13793 | - | 555 | WP_249014883.1 | helix-turn-helix transcriptional regulator | - |
MIH18_RS23625 (MIH18_23625) | 13806..14045 | + | 240 | WP_249014884.1 | YdaS family helix-turn-helix protein | - |
MIH18_RS23995 | 14423..14554 | - | 132 | WP_283164909.1 | hypothetical protein | - |
MIH18_RS23630 (MIH18_23630) | 14713..14961 | + | 249 | WP_249014885.1 | hypothetical protein | - |
MIH18_RS23635 (MIH18_23635) | 14976..15227 | + | 252 | WP_249014886.1 | DNA translocase FtsK | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..46935 | 46935 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7156.36 Da Isoelectric Point: 10.8998
>T235879 WP_249014877.1 NZ_CP092286:9839-10027 [Marinobacter sp. M3C]
MKSADIIKRLKAEGWVKVGGKGDHEKFKHPEKPGHVVVPHPRKDMPLGTLRSIYRQAGWDWR
MKSADIIKRLKAEGWVKVGGKGDHEKFKHPEKPGHVVVPHPRKDMPLGTLRSIYRQAGWDWR
Download Length: 189 bp
>T235879 NZ_LR134478:548421-549371 [Serratia plymuthica]
ATGGATGATTTAACAACGCTATTCCCAGATGTTGCCGATGCTCTGGGCATTGAATCAGTTGCAATTGTAGAGAAAGATTA
TTACATCGTTGAGTTATTGCGATTGCTCCAGCCTCTGGTTTTTGATACGCATCAACTGGTTTTTGCCGGTGGAACGGCAT
TGTCAAAAGCGGGGATATCTTTGAACAGGATGTCGGAGGACGTGGACATTAAGCTTGTCCCTGCCGCCGGTTTTTCCCAG
CAATATTCCAGAGGTCAGCGTAAAAACATCCGTAAGGGTATTATTCAGACCATTATCGAAACGATTGCAGCTTCTGGTAC
GTTTCGCCTGGATGAAGAGTATCCAAAGGTTACTCGTGATGAATATCGCTATAATGAAATTCCGGTACGCTACCCGCAGG
AATATGCACAAATTCCCTGCTTAAGGCCATTTATCAAACTGGAACTAATGGAAACAGATTTGCTTGAGGTTGCGGAAAAC
CGCGCTATTAGTTCATTGGTAATGGATCTAACAAAGAAGGGCGAAGTAGTGGGGGCTTTCCCCTGCGCAACTATCACCAG
CACGCAGGCTGAAAAGCTGATTTCGATGATGCGCAGAACGGCTGCAAGCATGCGTGATGTGGAGCGTGCGGTGGATGAGT
CACTGGTGCGTCATATCTACGACAATTTTTGTATAGTTAGAGAAAAAGGTTCTGACGTTCCTGTTTTGAAGCACTTGGTG
CAGGAATGCATTGAGCAGGATATTGAACGTTACGGTGCCCAGTACCCTGAATTCTGCGAATCGCCTGTTGAAGAGCTGAA
AATGGGGCTGGAAGAACTGGCGAGCAATCCTGTTTATAAGGAACGCTATCTGCACTTTGTTACACCAATGGTATTCGGTA
AAAGCCAGGTTTCCTGGGAAGAGGCCTATATCTGTTTTCGCAAGACGGCATTGGATGTGGTTGATGCATAG
ATGGATGATTTAACAACGCTATTCCCAGATGTTGCCGATGCTCTGGGCATTGAATCAGTTGCAATTGTAGAGAAAGATTA
TTACATCGTTGAGTTATTGCGATTGCTCCAGCCTCTGGTTTTTGATACGCATCAACTGGTTTTTGCCGGTGGAACGGCAT
TGTCAAAAGCGGGGATATCTTTGAACAGGATGTCGGAGGACGTGGACATTAAGCTTGTCCCTGCCGCCGGTTTTTCCCAG
CAATATTCCAGAGGTCAGCGTAAAAACATCCGTAAGGGTATTATTCAGACCATTATCGAAACGATTGCAGCTTCTGGTAC
GTTTCGCCTGGATGAAGAGTATCCAAAGGTTACTCGTGATGAATATCGCTATAATGAAATTCCGGTACGCTACCCGCAGG
AATATGCACAAATTCCCTGCTTAAGGCCATTTATCAAACTGGAACTAATGGAAACAGATTTGCTTGAGGTTGCGGAAAAC
CGCGCTATTAGTTCATTGGTAATGGATCTAACAAAGAAGGGCGAAGTAGTGGGGGCTTTCCCCTGCGCAACTATCACCAG
CACGCAGGCTGAAAAGCTGATTTCGATGATGCGCAGAACGGCTGCAAGCATGCGTGATGTGGAGCGTGCGGTGGATGAGT
CACTGGTGCGTCATATCTACGACAATTTTTGTATAGTTAGAGAAAAAGGTTCTGACGTTCCTGTTTTGAAGCACTTGGTG
CAGGAATGCATTGAGCAGGATATTGAACGTTACGGTGCCCAGTACCCTGAATTCTGCGAATCGCCTGTTGAAGAGCTGAA
AATGGGGCTGGAAGAACTGGCGAGCAATCCTGTTTATAAGGAACGCTATCTGCACTTTGTTACACCAATGGTATTCGGTA
AAAGCCAGGTTTCCTGGGAAGAGGCCTATATCTGTTTTCGCAAGACGGCATTGGATGTGGTTGATGCATAG
Antitoxin
Download Length: 130 a.a. Molecular weight: 14083.94 Da Isoelectric Point: 4.5927
>AT235879 WP_249014878.1 NZ_CP092286:10030-10419 [Marinobacter sp. M3C]
MLFPVYVHTGDDTHAHGAEVPDFPGCFSAADNWDALAGNIQEAVELHCEDEDMAVPAPTSLGKLMGSPDYQGGIWMMVDI
DTGKLRTKSVRLNVSLPEGLLRRIDDEAKIRHMSRSAFLAMSAQRELGA
MLFPVYVHTGDDTHAHGAEVPDFPGCFSAADNWDALAGNIQEAVELHCEDEDMAVPAPTSLGKLMGSPDYQGGIWMMVDI
DTGKLRTKSVRLNVSLPEGLLRRIDDEAKIRHMSRSAFLAMSAQRELGA
Download Length: 390 bp
>AT235879 NZ_LR134478:548033-548428 [Serratia plymuthica]
ATGACCATAAAAGCTCGTATTCAGTCACGACTGAAACGCTCAAAGCGTTATGTTTTCACTCGTGACGATTTCAAAGATCT
TGCTGGTTACGATCAAATTGGCAGAGCACTGCGTGAACTGGTGAAGGAAGGACAGCTGTTGAAAGTAGGCTATGGCGTCT
ATACCAAAGCGCGGCAAAATGTGATTACCGGCAAGTTGATGCCTGCTGCTCCCGGAGGTTCTGCTGCGGTAGTGATTGAG
GCGTTGGAACGTCTGAACGTGGATTACCGCTTGGTTGGAGCAACAAGCGCCTATAATAGTGGTAAATCCACTCAGATCCC
CGCGTCACTGGAAATCAAAACCTCACCACGTTTTAAGAGAACGTTGTCAGTAGGGAACAGTAAATTAAATGGATGA
ATGACCATAAAAGCTCGTATTCAGTCACGACTGAAACGCTCAAAGCGTTATGTTTTCACTCGTGACGATTTCAAAGATCT
TGCTGGTTACGATCAAATTGGCAGAGCACTGCGTGAACTGGTGAAGGAAGGACAGCTGTTGAAAGTAGGCTATGGCGTCT
ATACCAAAGCGCGGCAAAATGTGATTACCGGCAAGTTGATGCCTGCTGCTCCCGGAGGTTCTGCTGCGGTAGTGATTGAG
GCGTTGGAACGTCTGAACGTGGATTACCGCTTGGTTGGAGCAACAAGCGCCTATAATAGTGGTAAATCCACTCAGATCCC
CGCGTCACTGGAAATCAAAACCTCACCACGTTTTAAGAGAACGTTGTCAGTAGGGAACAGTAAATTAAATGGATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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