Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-XRE
Location 4454227..4455878 Replicon chromosome
Accession NZ_CP092284
Organism Marinobacter sp. M3C

Toxin (Protein)


Gene name HipA3 Uniprot ID -
Locus tag MIH18_RS20920 Protein ID WP_249013395.1
Coordinates 4454565..4455878 (+) Length 438 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID -
Locus tag MIH18_RS20915 Protein ID WP_249013394.1
Coordinates 4454227..4454568 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIH18_RS20885 (MIH18_20880) 4451564..4451866 + 303 WP_249005379.1 integration host factor subunit alpha -
MIH18_RS20890 (MIH18_20885) 4452007..4452357 + 351 WP_249013392.1 MerR family transcriptional regulator -
MIH18_RS20895 (MIH18_20890) 4452476..4452667 + 192 WP_249005377.1 hypothetical protein -
MIH18_RS20900 (MIH18_20895) 4452730..4453029 + 300 WP_249005376.1 nucleotidyltransferase domain-containing protein -
MIH18_RS20905 (MIH18_20900) 4453026..4453511 + 486 WP_249013393.1 hypothetical protein -
MIH18_RS20910 (MIH18_20905) 4453702..4453860 + 159 Protein_4130 MerR family transcriptional regulator -
MIH18_RS20915 (MIH18_20910) 4454227..4454568 + 342 WP_249013394.1 helix-turn-helix transcriptional regulator Antitoxin
MIH18_RS20920 (MIH18_20915) 4454565..4455878 + 1314 WP_249013395.1 type II toxin-antitoxin system HipA family toxin Toxin
MIH18_RS20925 (MIH18_20920) 4455927..4456568 - 642 WP_249013396.1 transposase -
MIH18_RS20930 (MIH18_20925) 4456746..4457135 + 390 WP_249014657.1 helix-turn-helix transcriptional regulator -
MIH18_RS20935 (MIH18_20930) 4457204..4458499 - 1296 WP_249013397.1 type II toxin-antitoxin system HipA family toxin -
MIH18_RS20940 (MIH18_20935) 4458496..4458774 - 279 WP_249005370.1 XRE family transcriptional regulator -
MIH18_RS20945 (MIH18_20940) 4458909..4460681 - 1773 WP_249013398.1 SLC13 family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(172-412)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-67)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 48891.98 Da        Isoelectric Point: 6.0651

>T235877 WP_249013395.1 NZ_CP092284:4454565-4455878 [Marinobacter sp. M3C]
VSTVTEVILWGKSVGALLYDTETGLSTFEYDKGWLKQDVSISPLHLPPRAGRFNFPSLPQETFFGLPGVFADTLPDDFGN
AVINAWLARQGIPKSSFSPVDRLLYTGNRGMGALEYKPDGRNTQTQVSGDIKVDTLVELAQSVLDQRAGLDVAISEGDEN
NDAMSAIFQVGTSAGGARPKAVIAVNRDRSRVVSGQTPIPEGFTHYLIKFDGVKERSSTSEVFGDPQGYGRMEYAYYLMA
KDAGINMAPSELLIEGARAHFMTQRFDRDGDRKRHYQSLCAMDHADFRKPGQYSYEELMTIARTLGLPRVDAIEIFRRMV
FNVIARNQDDHTKNFGFLLDHSTAGWRLAPAFDIAYSYKPGSYWVDTHQMTINGKRDKFTRGDILAVATQIPRFESNARA
IIDQVTEVVNQWQDYARRADVHSELSQEIYSNLRLSL

Download         Length: 1314 bp

>T235877 NZ_LR134477:c1996233-1995982 [Actinomyces viscosus]
GTGTCCATCAGTGCAAGTGAGGCTCGCAAGACGCTGTACCCGCTCATCGAGCGGGTCAATGCAGATCATGACGCTGTAGA
GATTGTTTCGCGTAAGGGCGCTGTTGTTCTTATGCCTGCCGACGAGTACGCCGCCTGGCAGGAGACCGCCTACCTGTTCC
GGTCGCCTGAAAACGCGCGACGCCTTCTCGACGCCTACGACCGGGCTCGTTCGGGCCGTACTGAGACCCATGATCTCGAC
TGGGAGGACTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12460.37 Da        Isoelectric Point: 10.0404

>AT235877 WP_249013394.1 NZ_CP092284:4454227-4454568 [Marinobacter sp. M3C]
MSQIKRSMSDLAILDELGRRLKQARLEQNITQQQIAEGMGVSRATYIRLEDGNGKLEVLVAALRVLGKLPALDAFLPDEP
YSPIAALKSAGHIRQRARPGNKPVEQDKGGLDW

Download         Length: 342 bp

>AT235877 NZ_LR134477:c1995982-1995728 [Actinomyces viscosus]
ATGCGTCTCGTATGGGACCCGTCTGCTTGGGAGGACTACAAGCATTGGCAGACGACGGATCGTCGGGTCCTCAAACGAGT
CAACACACTCATTGGTGCAGCTCTTCGCGACCCCTTCGGTGGCATCGGCAAACCCGAACAGCTCAAGTACGGCGCCTCGG
GCGCATGGTCGCGGAGGATCAGTGACGAGCACCGTCTTGTGTATCTCGTTGTTGGCGATGACCTGGTGATTCTTCAGGCT
CGCTACCACTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References