Detailed information of TA system TA235876

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-YefM
• Location: 2641320..2641822
• Replicon: chromosome
• Accession: NZ_CP092284
• Organism: Marinobacter sp. M3C

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: MIH18_RS12465
• Protein ID: WP_249012536.1
• Coordinates: 2641568..2641822 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R8B220
• Locus tag: MIH18_RS12460
• Protein ID: WP_012137510.1
• Coordinates: 2641320..2641571 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MIH18_RS12430 (MIH18_12425)	2636700..2637173	-	474	WP_249012531.1	hypothetical protein	-
MIH18_RS12435 (MIH18_12430)	2638122..2638586	-	465	WP_249012532.1	hypothetical protein	-
MIH18_RS12440 (MIH18_12435)	2638728..2639204	-	477	WP_249012533.1	helix-turn-helix domain-containing protein	-
MIH18_RS12445 (MIH18_12440)	2639306..2640046	+	741	WP_249012534.1	SDR family oxidoreductase	-
MIH18_RS12450 (MIH18_12445)	2640060..2640644	+	585	WP_249008570.1	2-hydroxychromene-2-carboxylate isomerase	-
MIH18_RS12455 (MIH18_12450)	2640791..2641165	-	375	WP_249012535.1	hypothetical protein	-
MIH18_RS12460 (MIH18_12455)	2641320..2641571	+	252	WP_012137510.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
MIH18_RS12465 (MIH18_12460)	2641568..2641822	+	255	WP_249012536.1	Txe/YoeB family addiction module toxin	Toxin
MIH18_RS12470 (MIH18_12465)	2642251..2642619	-	369	WP_249012537.1	type II toxin-antitoxin system RelE/ParE family toxin	-
MIH18_RS12475 (MIH18_12470)	2642616..2642897	-	282	WP_249012538.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
MIH18_RS12485 (MIH18_12480)	2643191..2644100	+	910	Protein_2448	integron integrase	-
MIH18_RS12490 (MIH18_12485)	2644219..2645277	-	1059	WP_249012541.1	ribonucleotide-diphosphate reductase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2612316..2641822	29506
	-	inside	Integron	-	-	2627694..2644100	16406

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10221.77 Da
• Isoelectric Point: 9.8162

>T235876 WP_249012536.1 NZ_CP092284:2641568-2641822 [Marinobacter sp. M3C]
MKLIFSENAWEDYLYWQKTDKKALNRINKLIKETKREPFEGVGKPEPLKHNLAGYWSRRINEEHRIVYKVTDDALLIAQL
RYHY

Nucleotide

• Length: 255 bp

>T235876 NZ_LR134477:c1995982-1995728 [Actinomyces viscosus]
ATGCGTCTCGTATGGGACCCGTCTGCTTGGGAGGACTACAAGCATTGGCAGACGACGGATCGTCGGGTCCTCAAACGAGT
CAACACACTCATTGGTGCAGCTCTTCGCGACCCCTTCGGTGGCATCGGCAAACCCGAACAGCTCAAGTACGGCGCCTCGG
GCGCATGGTCGCGGAGGATCAGTGACGAGCACCGTCTTGTGTATCTCGTTGTTGGCGATGACCTGGTGATTCTTCAGGCT
CGCTACCACTACTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9269.50 Da
• Isoelectric Point: 4.4750

>AT235876 WP_012137510.1 NZ_CP092284:2641320-2641571 [Marinobacter sp. M3C]
MDAISYTAARTNLAKTMEQVCEDHSPVIITRSKSQSVVMISLEDYEALQETAYLLRAPKNARRLLESVAELEQGGGQEKE
LLE

Nucleotide

• Length: 252 bp

>AT235876 NZ_LR134477:c1996233-1995982 [Actinomyces viscosus]
GTGTCCATCAGTGCAAGTGAGGCTCGCAAGACGCTGTACCCGCTCATCGAGCGGGTCAATGCAGATCATGACGCTGTAGA
GATTGTTTCGCGTAAGGGCGCTGTTGTTCTTATGCCTGCCGACGAGTACGCCGCCTGGCAGGAGACCGCCTACCTGTTCC
GGTCGCCTGAAAACGCGCGACGCCTTCTCGACGCCTACGACCGGGCTCGTTCGGGCCGTACTGAGACCCATGATCTCGAC
TGGGAGGACTGA

Structures

Antitoxin

• AlphaFold DB: A0A844I226