Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 2614845..2615352 Replicon chromosome
Accession NZ_CP092284
Organism Marinobacter sp. M3C

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MIH18_RS12270 Protein ID WP_249006763.1
Coordinates 2615179..2615352 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag MIH18_RS12265 Protein ID WP_249006762.1
Coordinates 2614845..2615099 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIH18_RS12235 (MIH18_12230) 2610159..2611007 - 849 WP_249006756.1 putative selenate ABC transporter substrate-binding protein -
MIH18_RS12240 (MIH18_12235) 2611287..2611925 - 639 WP_249006757.1 SGNH/GDSL hydrolase family protein -
MIH18_RS12245 (MIH18_12240) 2612316..2612645 - 330 WP_249012517.1 DHCW motif cupin fold protein -
MIH18_RS12250 (MIH18_12245) 2612745..2613008 - 264 WP_249006759.1 Txe/YoeB family addiction module toxin -
MIH18_RS12255 (MIH18_12250) 2613005..2613247 - 243 WP_249006760.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MIH18_RS12260 (MIH18_12255) 2613487..2614434 - 948 WP_249006761.1 D-hexose-6-phosphate mutarotase -
MIH18_RS12265 (MIH18_12260) 2614845..2615099 - 255 WP_249006762.1 CopG family transcriptional regulator Antitoxin
MIH18_RS12270 (MIH18_12265) 2615179..2615352 - 174 WP_249006763.1 BrnT family toxin Toxin
MIH18_RS12275 (MIH18_12270) 2615482..2615898 - 417 WP_249006764.1 GFA family protein -
MIH18_RS12280 (MIH18_12275) 2616250..2616546 - 297 WP_249006765.1 type II toxin-antitoxin system RelE/ParE family toxin -
MIH18_RS12285 (MIH18_12280) 2616546..2616800 - 255 WP_249006766.1 type II toxin-antitoxin system ParD family antitoxin -
MIH18_RS12290 (MIH18_12285) 2616994..2617293 - 300 WP_249006767.1 hypothetical protein -
MIH18_RS12295 (MIH18_12290) 2617414..2617896 - 483 WP_249006768.1 SgcJ/EcaC family oxidoreductase -
MIH18_RS12300 (MIH18_12295) 2618012..2618293 - 282 WP_249006769.1 type II toxin-antitoxin system RelE/ParE family toxin -
MIH18_RS12305 (MIH18_12300) 2618290..2618562 - 273 WP_249006770.1 ribbon-helix-helix protein, CopG family -
MIH18_RS12310 (MIH18_12305) 2618766..2619011 + 246 WP_249006771.1 type II toxin-antitoxin system CcdA family antitoxin -
MIH18_RS12315 (MIH18_12310) 2619011..2619328 + 318 WP_072795464.1 CcdB family protein -
MIH18_RS12320 (MIH18_12315) 2619421..2619909 - 489 WP_249006772.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2612316..2641822 29506


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-56)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6676.57 Da        Isoelectric Point: 5.0495

>T235875 WP_249006763.1 NZ_CP092284:c2615352-2615179 [Marinobacter sp. M3C]
MDEFEFDETKSQTNLDKHGIDFVAARVLWKDPYLLEIRAKSEGEPRFVLIGKIGERH

Download         Length: 174 bp

>T235875 NZ_LR134475:3959041-3959259 [Klebsiella aerogenes]
ATGTCTGGTAAACCATTAACTAAAACAGACTATTTGATGCGTTTACGCCGCTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAGAATAAATATGAACTTTCCGACAATGAATTGGCGGTATTTTACTCAGCAGCCGACCATCGTCTTGCTGAAT
TGACCATGAATAAGCTATACGACAAAATCCCAACTTCAGTATGGAAATTTATCCGCTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9814.09 Da        Isoelectric Point: 5.8726

>AT235875 WP_249006762.1 NZ_CP092284:c2615099-2614845 [Marinobacter sp. M3C]
MKARDFDKKFEEGQDDIVDDLDLSTVRRVNQEQKRINVDFPAWVVESLDREAARIGVTRQSIIKVWLVERLQAESANKCV
TRTH

Download         Length: 255 bp

>AT235875 NZ_LR134475:3958640-3959014 [Klebsiella aerogenes]
ATGGACGAGTACTCGCCAAAAAGACATGATATCGCGCAGCTAAGATTTCTCTGCGAAACGTTGTATCATGACTGCCTTGC
AAACCTGGAAGAAAGCAACCGCGGCTGGGTTAACGACCCCACCTCGGCGGTGAATCTTCAATTAAATGAATTGATCGAGC
ACATAGCAACTTACGCGCTTAATTATAAAATTAAGTACGCTGAGGATAATAAGCTGATTTCTCAGCTTGACGAATACCTG
GATGACACTTTTATGCTGTTCAGTAGCTATGGCATAAACACAAGCGATCTCCAAAAATGGCGCAAATCCGGCAATCGGTT
ATTCCGATGCTTTGTGAACGCCAGCCGGGAGAACCCGGCAAGTCTTTCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References