Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yoeB-relB/Txe-YefM |
| Location | 2612745..2613247 | Replicon | chromosome |
| Accession | NZ_CP092284 | ||
| Organism | Marinobacter sp. M3C | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | - |
| Locus tag | MIH18_RS12250 | Protein ID | WP_249006759.1 |
| Coordinates | 2612745..2613008 (-) | Length | 88 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | MIH18_RS12255 | Protein ID | WP_249006760.1 |
| Coordinates | 2613005..2613247 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MIH18_RS12225 (MIH18_12220) | 2608025..2609491 | - | 1467 | WP_249006754.1 | ABC transporter permease | - |
| MIH18_RS12230 (MIH18_12225) | 2609509..2610159 | - | 651 | WP_249006755.1 | ATP-binding cassette domain-containing protein | - |
| MIH18_RS12235 (MIH18_12230) | 2610159..2611007 | - | 849 | WP_249006756.1 | putative selenate ABC transporter substrate-binding protein | - |
| MIH18_RS12240 (MIH18_12235) | 2611287..2611925 | - | 639 | WP_249006757.1 | SGNH/GDSL hydrolase family protein | - |
| MIH18_RS12245 (MIH18_12240) | 2612316..2612645 | - | 330 | WP_249012517.1 | DHCW motif cupin fold protein | - |
| MIH18_RS12250 (MIH18_12245) | 2612745..2613008 | - | 264 | WP_249006759.1 | Txe/YoeB family addiction module toxin | Toxin |
| MIH18_RS12255 (MIH18_12250) | 2613005..2613247 | - | 243 | WP_249006760.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| MIH18_RS12260 (MIH18_12255) | 2613487..2614434 | - | 948 | WP_249006761.1 | D-hexose-6-phosphate mutarotase | - |
| MIH18_RS12265 (MIH18_12260) | 2614845..2615099 | - | 255 | WP_249006762.1 | CopG family transcriptional regulator | - |
| MIH18_RS12270 (MIH18_12265) | 2615179..2615352 | - | 174 | WP_249006763.1 | BrnT family toxin | - |
| MIH18_RS12275 (MIH18_12270) | 2615482..2615898 | - | 417 | WP_249006764.1 | GFA family protein | - |
| MIH18_RS12280 (MIH18_12275) | 2616250..2616546 | - | 297 | WP_249006765.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| MIH18_RS12285 (MIH18_12280) | 2616546..2616800 | - | 255 | WP_249006766.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| MIH18_RS12290 (MIH18_12285) | 2616994..2617293 | - | 300 | WP_249006767.1 | hypothetical protein | - |
| MIH18_RS12295 (MIH18_12290) | 2617414..2617896 | - | 483 | WP_249006768.1 | SgcJ/EcaC family oxidoreductase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2612316..2641822 | 29506 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 88 a.a. Molecular weight: 10073.76 Da Isoelectric Point: 10.2588
>T235874 WP_249006759.1 NZ_CP092284:c2613008-2612745 [Marinobacter sp. M3C]
VTWKLVYTKQAQKDAKKLAASSLKPKAQGLLALIAEDPYRRPPPFEKLIGDLAGAYSRRINIQHRVVYEVLEDERVVKVL
RLWSHYE
VTWKLVYTKQAQKDAKKLAASSLKPKAQGLLALIAEDPYRRPPPFEKLIGDLAGAYSRRINIQHRVVYEVLEDERVVKVL
RLWSHYE
Download Length: 264 bp
>T235874 NZ_LR134475:2653072-2653557 [Klebsiella aerogenes]
ATGGGAAAAATAAGTGCGCCTGCACCGCTATCTTCACACCATCAGATTGCGGAGTTTTGTTGTGGAGAAACGGTTCTCGA
TCAATGGCTAAAACAACGAGGAATGAAAAACCAGGCTCAGGGTGCCGCGAGAACCTTTGTGGTCTGCAAGGAAGATAGCC
ATCAGGTGGTGGGGTTTTATTCGTTAGCAACCGGCAGCGTTAATCACACTGAAGCCACTGGCGACCTGCGGCGCAATATG
CCCGATCCTATCCCGGTCATCATTCTCGCCCGCCTGGCGATCGACTGCGCGTTTCACGGACAGGGGCTGGGAGCTGATTT
ACTCCATGATGCGCTCTTACGCAGTTATCGCGTTGCCGAAAATGTTGGCGTACGTGCCCTGATGGTCCATGCCCTGACCG
ATAGCGCGAAGCGATTCTATTTACACCACGGATTCAAAGCCTCCACCACCCAGGAACGCACACTTTTCCTCGCGTTGCCT
AAATAA
ATGGGAAAAATAAGTGCGCCTGCACCGCTATCTTCACACCATCAGATTGCGGAGTTTTGTTGTGGAGAAACGGTTCTCGA
TCAATGGCTAAAACAACGAGGAATGAAAAACCAGGCTCAGGGTGCCGCGAGAACCTTTGTGGTCTGCAAGGAAGATAGCC
ATCAGGTGGTGGGGTTTTATTCGTTAGCAACCGGCAGCGTTAATCACACTGAAGCCACTGGCGACCTGCGGCGCAATATG
CCCGATCCTATCCCGGTCATCATTCTCGCCCGCCTGGCGATCGACTGCGCGTTTCACGGACAGGGGCTGGGAGCTGATTT
ACTCCATGATGCGCTCTTACGCAGTTATCGCGTTGCCGAAAATGTTGGCGTACGTGCCCTGATGGTCCATGCCCTGACCG
ATAGCGCGAAGCGATTCTATTTACACCACGGATTCAAAGCCTCCACCACCCAGGAACGCACACTTTTCCTCGCGTTGCCT
AAATAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9157.32 Da Isoelectric Point: 4.1317
>AT235874 WP_249006760.1 NZ_CP092284:c2613247-2613005 [Marinobacter sp. M3C]
MTGITATEARSNLYRLIDETAESHQPIVIMGKRNRAVLVSEEDWSAIQETLYLLSVPGMRESIREGMETPMDQCDEELNW
MTGITATEARSNLYRLIDETAESHQPIVIMGKRNRAVLVSEEDWSAIQETLYLLSVPGMRESIREGMETPMDQCDEELNW
Download Length: 243 bp
>AT235874 NZ_LR134475:2652818-2653084 [Klebsiella aerogenes]
ATGAAATCAGATATCCAACTCAACATCCGGGCGAAGGAGTCCCAGCGGGCGCTGATTGATGCGGCTGCCGAAATTCTGCA
CAAATCGCGGACCGACTTTATCCTTGAGATGGCCTGCCAGGCGGCAGAAAACGTCATTCTCGACCGTCGGGTGTTTAACT
TAAGCGATGAGCAATACGCCGAATTTATCGACATGCTGGATGCGCCGGTTGAAGCTAACCCCGCTCTCGATAAATTGCTG
GCGAGAAAACCGCAATGGGAAAAATAA
ATGAAATCAGATATCCAACTCAACATCCGGGCGAAGGAGTCCCAGCGGGCGCTGATTGATGCGGCTGCCGAAATTCTGCA
CAAATCGCGGACCGACTTTATCCTTGAGATGGCCTGCCAGGCGGCAGAAAACGTCATTCTCGACCGTCGGGTGTTTAACT
TAAGCGATGAGCAATACGCCGAATTTATCGACATGCTGGATGCGCCGGTTGAAGCTAACCCCGCTCTCGATAAATTGCTG
GCGAGAAAACCGCAATGGGAAAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|