Detailed information of TA system TA235873

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1657910..1658564
• Replicon: chromosome
• Accession: NZ_CP092284
• Organism: Marinobacter sp. M3C

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: MIH18_RS07645
• Protein ID: WP_249007818.1
• Coordinates: 1657910..1658092 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: MIH18_RS07650
• Protein ID: WP_249014242.1
• Coordinates: 1658133..1658564 (+)
• Length: 144 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MIH18_RS07590 (MIH18_07585)	1653553..1653810	+	258	WP_249007826.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
MIH18_RS07595 (MIH18_07590)	1653810..1654082	+	273	WP_249007825.1	type II toxin-antitoxin system YafQ family toxin	-
MIH18_RS07600 (MIH18_07595)	1654346..1654819	+	474	WP_249007824.1	outer membrane protein assembly factor BamE	-
MIH18_RS07605 (MIH18_07600)	1654929..1655117	-	189	Protein_1496	ATP-binding protein	-
MIH18_RS07610 (MIH18_07605)	1655260..1655379	+	120	Protein_1497	type II toxin-antitoxin system RelE/ParE family toxin	-
MIH18_RS07615 (MIH18_07610)	1655411..1655791	-	381	WP_249007823.1	helix-turn-helix transcriptional regulator	-
MIH18_RS07620 (MIH18_07615)	1655909..1656211	-	303	WP_249007822.1	XRE family transcriptional regulator	-
MIH18_RS07625 (MIH18_07620)	1656213..1656536	-	324	Protein_1500	type II toxin-antitoxin system RelE/ParE family toxin	-
MIH18_RS07630 (MIH18_07625)	1656566..1656865	-	300	WP_249014241.1	type II toxin-antitoxin system RelE/ParE family toxin	-
MIH18_RS07635 (MIH18_07630)	1656862..1657128	-	267	WP_249007820.1	YlcI/YnfO family protein	-
MIH18_RS07640 (MIH18_07635)	1657263..1657805	+	543	WP_249007819.1	hypothetical protein	-
MIH18_RS07645 (MIH18_07640)	1657910..1658092	+	183	WP_249007818.1	type II toxin-antitoxin system HicA family toxin	Toxin
MIH18_RS07650 (MIH18_07645)	1658133..1658564	+	432	WP_249014242.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
MIH18_RS07660 (MIH18_07655)	1659035..1659469	+	435	WP_283164857.1	pilin	-
MIH18_RS07665 (MIH18_07660)	1659594..1661504	+	1911	WP_249014243.1	tetratricopeptide repeat protein	-
MIH18_RS07670 (MIH18_07665)	1661519..1662373	+	855	WP_249014244.1	glycosyltransferase family 2 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6849.86 Da
• Isoelectric Point: 10.6217

>T235873 WP_249007818.1 NZ_CP092284:1657910-1658092 [Marinobacter sp. M3C]
VTSDEVKKKLEKDGWELVRVNGSHHHFKHSTKPGLVTLPHPKSELPKGTLNNIWKQAGWK

Nucleotide

• Length: 183 bp

>T235873 NZ_LR134475:1990368-1990471 [Klebsiella aerogenes]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 144 a.a.
• Molecular weight: 15842.93 Da
• Isoelectric Point: 6.3367

>AT235873 WP_249014242.1 NZ_CP092284:1658133-1658564 [Marinobacter sp. M3C]
MRFPVALHTDDGKNYGVTVPDIPGCFSAGSNEDKALDNAREAILGHLELLAEFGEDIPTANSIAEHRTNADFKGAVWGFI
EIDVTPFLGKAEKINITVPRLVLRQIDRYVKEHPNEARSRSAFLSEAALERMRKSHDKAKTLA

Nucleotide

• Length: 432 bp

>AT235873 NZ_LR134475:c1990479-1990333 [Klebsiella aerogenes]
TAATAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAA
GTTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTATAAGAATAGTTGACTGTGACAGGTTTTCCAGT