Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
Location | 331072..331781 | Replicon | chromosome |
Accession | NC_012207 | ||
Organism | Mycobacterium bovis BCG str. Tokyo 172 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | P9WF84 |
Locus tag | JTY_RS01465 | Protein ID | WP_003401406.1 |
Coordinates | 331072..331500 (-) | Length | 143 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A7U4BRN8 |
Locus tag | JTY_RS01470 | Protein ID | WP_011799093.1 |
Coordinates | 331524..331781 (-) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JTY_RS01440 | 326939..328072 | - | 1134 | WP_003401394.1 | hypothetical protein | - |
JTY_RS01445 | 328069..328689 | - | 621 | WP_003401397.1 | TetR/AcrR family transcriptional regulator | - |
JTY_RS01450 | 328786..329367 | + | 582 | WP_003401399.1 | VOC family protein | - |
JTY_RS01455 | 329297..330022 | - | 726 | WP_003902925.1 | TetR/AcrR family transcriptional regulator | - |
JTY_RS01460 | 330112..331032 | + | 921 | WP_003401404.1 | DUF2236 domain-containing protein | - |
JTY_RS01465 | 331072..331500 | - | 429 | WP_003401406.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
JTY_RS01470 | 331524..331781 | - | 258 | WP_011799093.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
JTY_RS01475 | 331866..334616 | - | 2751 | WP_011799094.1 | PE family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 143 a.a. Molecular weight: 15887.27 Da Isoelectric Point: 7.2214
>T23587 WP_003401406.1 NC_012207:c331500-331072 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
MFLIDVNVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLTTNRRIFEIPSPRADAFAFVEAVNAQPHHL
PTSPGPRHLVLLRKLCDEADASGDLIPDAVLGAIAVEHHCAVVSLDRDFARFASVRHIRPPI
MFLIDVNVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLTTNRRIFEIPSPRADAFAFVEAVNAQPHHL
PTSPGPRHLVLLRKLCDEADASGDLIPDAVLGAIAVEHHCAVVSLDRDFARFASVRHIRPPI
Download Length: 429 bp
>T23587 NC_012207:c331500-331072 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
ATGTTCCTCATCGACGTCAACGTGCTGCTGGCTGCACACCGCGGTGACCATCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTTGCGGCCGACGACCCCTTCACAGTGCCGAACCTAGTGTGGGCGTCGTTCCTCCGGCTAACAACGAATC
GACGCATCTTCGAGATTCCGTCACCACGAGCGGATGCATTCGCATTCGTCGAAGCCGTCAACGCCCAGCCCCATCACCTT
CCGACAAGCCCCGGCCCCAGACACCTGGTGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGGGGCCATCGCCGTGGAGCATCACTGCGCCGTGGTGAGCCTGGATAGGGATTTCGCCCGGTTTGCCT
CTGTGCGCCATATTCGCCCGCCAATCTAG
ATGTTCCTCATCGACGTCAACGTGCTGCTGGCTGCACACCGCGGTGACCATCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTTGCGGCCGACGACCCCTTCACAGTGCCGAACCTAGTGTGGGCGTCGTTCCTCCGGCTAACAACGAATC
GACGCATCTTCGAGATTCCGTCACCACGAGCGGATGCATTCGCATTCGTCGAAGCCGTCAACGCCCAGCCCCATCACCTT
CCGACAAGCCCCGGCCCCAGACACCTGGTGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGGGGCCATCGCCGTGGAGCATCACTGCGCCGTGGTGAGCCTGGATAGGGATTTCGCCCGGTTTGCCT
CTGTGCGCCATATTCGCCCGCCAATCTAG
Antitoxin
Download Length: 86 a.a. Molecular weight: 9114.32 Da Isoelectric Point: 10.6530
>AT23587 WP_011799093.1 NC_012207:c331781-331524 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
MRTTVSISDELLATAKRRARERGQSLGAVIEDALRRELAAARTGGARPTVPVFDAGTGPRPGIDLTSNRVLSEVLDEGLE
LNSRK
MRTTVSISDELLATAKRRARERGQSLGAVIEDALRRELAAARTGGARPTVPVFDAGTGPRPGIDLTSNRVLSEVLDEGLE
LNSRK
Download Length: 258 bp
>AT23587 NC_012207:c331781-331524 [Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172]
ATGCGCACCACCGTGTCAATCTCCGATGAACTACTGGCTACCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAAGACGCCCTTCGGCGGGAGCTCGCCGCCGCCCGCACCGGCGGCGCCCGGCCAACCGTCCCCGTTTTTG
ACGCCGGCACCGGTCCGCGGCCAGGTATCGACCTAACCTCGAATAGGGTGTTGTCCGAAGTGCTCGACGAGGGTCTGGAA
CTGAACTCGCGGAAGTGA
ATGCGCACCACCGTGTCAATCTCCGATGAACTACTGGCTACCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAAGACGCCCTTCGGCGGGAGCTCGCCGCCGCCCGCACCGGCGGCGCCCGGCCAACCGTCCCCGTTTTTG
ACGCCGGCACCGGTCCGCGGCCAGGTATCGACCTAACCTCGAATAGGGTGTTGTCCGAAGTGCTCGACGAGGGTCTGGAA
CTGAACTCGCGGAAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BRM6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BRN8 |