Detailed information of TA system TA235869

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpA-brnA/BrnT_toxin-BrnA
• Location: 1584052..1584562
• Replicon: chromosome
• Accession: NZ_CP092284
• Organism: Marinobacter sp. M3C

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: -
• Locus tag: MIH18_RS07210
• Protein ID: WP_249007892.1
• Coordinates: 1584290..1584562 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: -
• Locus tag: MIH18_RS07205
• Protein ID: WP_249014229.1
• Coordinates: 1584052..1584306 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MIH18_RS23935	1579420..1581603	+	2184	WP_283164854.1	flagellin	-
MIH18_RS07190 (MIH18_07185)	1581743..1582084	-	342	WP_249014226.1	type II toxin-antitoxin system HicB family antitoxin	-
MIH18_RS07195 (MIH18_07190)	1582081..1582347	-	267	WP_249014227.1	hypothetical protein	-
MIH18_RS07200 (MIH18_07195)	1582584..1583993	-	1410	WP_249014228.1	plasmid pRiA4b ORF-3 family protein	-
MIH18_RS07205 (MIH18_07200)	1584052..1584306	-	255	WP_249014229.1	BrnA antitoxin family protein	Antitoxin
MIH18_RS07210 (MIH18_07205)	1584290..1584562	-	273	WP_249007892.1	BrnT family toxin	Toxin
MIH18_RS07215 (MIH18_07210)	1585000..1585296	+	297	WP_249007891.1	type II toxin-antitoxin system RelE/ParE family toxin	-
MIH18_RS07220 (MIH18_07215)	1585309..1585644	+	336	WP_249007890.1	putative addiction module antidote protein	-
MIH18_RS07225 (MIH18_07220)	1585710..1587440	-	1731	WP_249007889.1	single-stranded-DNA-specific exonuclease RecJ	-
MIH18_RS07230 (MIH18_07225)	1587446..1588846	-	1401	WP_249014230.1	threonine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-82)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (38-77)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10694.23 Da
• Isoelectric Point: 5.7237

>T235869 WP_249007892.1 NZ_CP092284:c1584562-1584290 [Marinobacter sp. M3C]
MYFEWDDSKNAANISKHGIDFRDAIDMFNHPMLTAIDECFMYGEERWTAIGLMREMVGVVVYTERRESVVRIISARKATR
REVRLYEQNI

Nucleotide

• Length: 273 bp

>T235869 NZ_LR134459:c20810-20391 [Tsukamurella tyrosinosolvens]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTT

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9934.29 Da
• Isoelectric Point: 5.8560

>AT235869 WP_249014229.1 NZ_CP092284:c1584306-1584052 [Marinobacter sp. M3C]
MSKTSKTDWKRLTEMEDDAIDTSDISELDDKFFQNAELLIPAKQPVTLRIDEDVLVWFKAQGRGYQTRINKLLRHYMESQ
VTKR

Nucleotide

• Length: 255 bp

>AT235869 NZ_LR134459:c21025-20807 [Tsukamurella tyrosinosolvens]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT