Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 20715..21346 Replicon chromosome
Accession NZ_CP092284
Organism Marinobacter sp. M3C

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MIH18_RS00090 Protein ID WP_249013532.1
Coordinates 20715..21116 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MIH18_RS00095 Protein ID WP_249013533.1
Coordinates 21116..21346 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIH18_RS00065 (MIH18_00065) 16661..18493 + 1833 WP_249013528.1 hypothetical protein -
MIH18_RS00070 (MIH18_00070) 18646..19287 - 642 WP_249013529.1 DUF642 domain-containing protein -
MIH18_RS00075 (MIH18_00075) 19605..19859 - 255 WP_249013530.1 AAA family ATPase -
MIH18_RS00080 (MIH18_00080) 19901..20263 + 363 WP_283164806.1 type II toxin-antitoxin system RelE/ParE family toxin -
MIH18_RS00085 (MIH18_00085) 20260..20580 + 321 WP_249013531.1 helix-turn-helix transcriptional regulator -
MIH18_RS00090 (MIH18_00090) 20715..21116 - 402 WP_249013532.1 tRNA(fMet)-specific endonuclease VapC Toxin
MIH18_RS00095 (MIH18_00095) 21116..21346 - 231 WP_249013533.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MIH18_RS00100 (MIH18_00100) 21501..22538 - 1038 WP_249013534.1 AAA family ATPase -
MIH18_RS00105 (MIH18_00105) 22557..23537 - 981 WP_249013535.1 DUF3473 domain-containing protein -
MIH18_RS00110 (MIH18_00110) 23739..25148 + 1410 WP_249013536.1 TIGR03013 family PEP-CTERM/XrtA system glycosyltransferase -
MIH18_RS00115 (MIH18_00115) 25203..25841 + 639 WP_249013537.1 polysaccharide biosynthesis/export family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 9898..112243 102345


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14778.02 Da        Isoelectric Point: 7.2758

>T235866 WP_249013532.1 NZ_CP092284:c21116-20715 [Marinobacter sp. M3C]
MLKYMLDTNIAIYTIKNRPAEVREAFIAHDGQMCISVVTFMELIYGAEASAAVRRNLRDVEGFAARLEVLPYDNDAAAHT
GQLRAELKKIGRPIGPYDEMIAGHARSQGLVVVTNNTKQFENVPGIRLANWMG

Download         Length: 402 bp

>T235866 NZ_LR134442:c2658961-2658695 [Propionibacterium australiense]
ATGGCCTGGACACTCCGGTTCAGCAGCGATTTTGAGCGCTCTCTGCACAAGCTGGACAGACAGACCGCCAGGCGCATCCT
GGTGAAGCTCCACGGACTTGTCTCACTCGACGAGCCTCAGGCGCGGTGCAAGGGCCTCGCTGGACCACTCGCGGGTCTGT
GGCGACTCCGCGTGGGCGATTACCGCGTCCTGCTCGACATCCGCCGTGCCGAGTTGGTCATCGTCGCCCTCGGCGTGGGT
CACCGCAGCTCTATCTACGACACGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8520.60 Da        Isoelectric Point: 4.7247

>AT235866 WP_249013533.1 NZ_CP092284:c21346-21116 [Marinobacter sp. M3C]
MERASIFKSNKSQALRLPKPVAYPDDVKQVDIVVIGRARIITPAGEAWDSWFDGEGVSGDFMTSREQPTPQERETL

Download         Length: 231 bp

>AT235866 NZ_LR134442:c2659233-2658961 [Propionibacterium australiense]
ATGTCTACGAGCGTGCTGAGCATCCGCCTTCCCGACGAGGTCAAGAACAGGCTGGACGCGCTGAGCGCCTCGACGGGCCG
CCCCGCAGCTTTCTACGTTCGCGAGGCCGTGCTGGAGCATCTTGATGAATTGGAGTGGGCCTACTCCCTCGCGGCCCGGG
CCGAGGCCATCCGCAACGGGACTGAGGAGACCCGATCCTTCGACGAGGTGGCGCGCGGGCTGGGTTTCGATCCCGATGAA
CTCCGCGCCGAGGCGAGCGAAGACCGCTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References