Detailed information of TA system TA235865

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/Txe-YefM
• Location: 4566606..4567108
• Replicon: chromosome
• Accession: NZ_CP092283
• Organism: Marinobacter sp. M4C

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: MIH16_RS21580
• Protein ID: WP_249006759.1
• Coordinates: 4566606..4566869 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MIH16_RS21585
• Protein ID: WP_249006760.1
• Coordinates: 4566866..4567108 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MIH16_RS21545 (MIH16_21545)	4561870..4562280	-	411	WP_249006807.1	hypothetical protein	-
MIH16_RS21550 (MIH16_21550)	4562358..4562648	-	291	WP_249006808.1	hypothetical protein	-
MIH16_RS21555 (MIH16_21555)	4562787..4563248	-	462	WP_249018579.1	hypothetical protein	-
MIH16_RS21560 (MIH16_21560)	4563272..4563967	-	696	WP_249006810.1	GNAT family N-acetyltransferase	-
MIH16_RS21565 (MIH16_21565)	4563942..4564247	-	306	WP_217632702.1	chorismate mutase	-
MIH16_RS21570 (MIH16_21570)	4564350..4565027	-	678	WP_249006811.1	HAD family phosphatase	-
MIH16_RS21575 (MIH16_21575)	4565131..4566096	-	966	WP_249006812.1	alcohol dehydrogenase catalytic domain-containing protein	-
MIH16_RS21580 (MIH16_21580)	4566606..4566869	-	264	WP_249006759.1	Txe/YoeB family addiction module toxin	Toxin
MIH16_RS21585 (MIH16_21585)	4566866..4567108	-	243	WP_249006760.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MIH16_RS21590 (MIH16_21590)	4567268..4567828	-	561	WP_249006813.1	hypothetical protein	-
MIH16_RS21595 (MIH16_21595)	4567927..4568244	-	318	WP_249006791.1	antibiotic biosynthesis monooxygenase	-
MIH16_RS21600 (MIH16_21600)	4568760..4568984	+	225	WP_249006796.1	hypothetical protein	-
MIH16_RS21605 (MIH16_21605)	4569178..4569543	-	366	WP_249006787.1	cupin domain-containing protein	-
MIH16_RS21610 (MIH16_21610)	4569775..4570733	+	959	Protein_4264	integron integrase	-
MIH16_RS21615 (MIH16_21615)	4570827..4571885	-	1059	WP_249006814.1	ribonucleotide-diphosphate reductase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4557632..4567828	10196
	-	inside	Integron	-	-	4557062..4570611	13549

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10073.76 Da
• Isoelectric Point: 10.2588

>T235865 WP_249006759.1 NZ_CP092283:c4566869-4566606 [Marinobacter sp. M4C]
VTWKLVYTKQAQKDAKKLAASSLKPKAQGLLALIAEDPYRRPPPFEKLIGDLAGAYSRRINIQHRVVYEVLEDERVVKVL
RLWSHYE

Nucleotide

• Length: 264 bp

>T235865 NZ_LR134442:c2094111-2093794 [Propionibacterium australiense]
GTGCGAGAGATCTGCCTGGCCGAGTTCGACAAGACCCGGCCCGTGCTCGTCCTCACCCGGGAACTCGCCCGAGAAGCGAT
GACGAAGGTCACCGTCGCACCCATCACGTCCACCGTCAAGGGATTGTCCAGCGAACTGCGCCTCGGACCGGACAACGGTC
TCGACCATGAGTGCGCGGCATCCCTCGACAACGTCGTGACGATTCCGGTGACGTCCCTGGGCCGGACGGTGGGTTTCCTC
GGACCCGACCAGGAACGAGCCCTCGCCGTGGCTGTTGTCCTTGCCTACGATCTGCAGGTCTCCCTCCTGGAGGACTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9157.32 Da
• Isoelectric Point: 4.1317

>AT235865 WP_249006760.1 NZ_CP092283:c4567108-4566866 [Marinobacter sp. M4C]
MTGITATEARSNLYRLIDETAESHQPIVIMGKRNRAVLVSEEDWSAIQETLYLLSVPGMRESIREGMETPMDQCDEELNW

Nucleotide

• Length: 243 bp

>AT235865 NZ_LR134442:c2094346-2094113 [Propionibacterium australiense]
ATGAGTGTCCAGATCACCGTTCGGCTTCCCGGCGAGCTCGTGTCTTTCCTCGACGACAGCGTGGCCGAGGGACGCGCGCA
GAGCCGGGCTGCGCTGGTGGCCTCCGCACTGGAACGGGAGATGCGGCGTCAGGCTGCGATCACGGATGCGAGGATCCTGG
CCGAGCAGGGCCCGGGCGATGACCTGGACGCATTGGTGTCCTGGTCGGTCTCGAACGCTGCCCTGGAGGACTGA