Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YefM |
| Location | 4552528..4553108 | Replicon | chromosome |
| Accession | NZ_CP092283 | ||
| Organism | Marinobacter sp. M4C | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | MIH16_RS21465 | Protein ID | WP_249006798.1 |
| Coordinates | 4552528..4552830 (-) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | MIH16_RS21470 | Protein ID | WP_249006799.1 |
| Coordinates | 4552827..4553108 (-) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MIH16_RS21420 (MIH16_21420) | 4548412..4548636 | + | 225 | Protein_4226 | transposase domain-containing protein | - |
| MIH16_RS21425 (MIH16_21425) | 4548794..4549111 | - | 318 | WP_249006791.1 | antibiotic biosynthesis monooxygenase | - |
| MIH16_RS21430 (MIH16_21430) | 4549225..4549551 | - | 327 | WP_249006792.1 | antibiotic biosynthesis monooxygenase | - |
| MIH16_RS21435 (MIH16_21435) | 4549645..4549965 | - | 321 | WP_249006793.1 | hypothetical protein | - |
| MIH16_RS21440 (MIH16_21440) | 4550112..4550363 | + | 252 | WP_012137510.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | - |
| MIH16_RS21445 (MIH16_21445) | 4550360..4550614 | + | 255 | WP_249006794.1 | Txe/YoeB family addiction module toxin | - |
| MIH16_RS21450 (MIH16_21450) | 4550835..4551026 | - | 192 | WP_249006795.1 | hypothetical protein | - |
| MIH16_RS21455 (MIH16_21455) | 4551120..4551344 | + | 225 | WP_249006796.1 | hypothetical protein | - |
| MIH16_RS21460 (MIH16_21460) | 4551522..4552424 | - | 903 | WP_249006797.1 | hypothetical protein | - |
| MIH16_RS21465 (MIH16_21465) | 4552528..4552830 | - | 303 | WP_249006798.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| MIH16_RS21470 (MIH16_21470) | 4552827..4553108 | - | 282 | WP_249006799.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| MIH16_RS21475 (MIH16_21475) | 4553273..4553560 | - | 288 | WP_249008970.1 | HigA family addiction module antitoxin | - |
| MIH16_RS21480 (MIH16_21480) | 4553571..4553849 | - | 279 | WP_249006800.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| MIH16_RS21485 (MIH16_21485) | 4553967..4554590 | - | 624 | WP_249006774.1 | SagB/ThcOx family dehydrogenase | - |
| MIH16_RS21490 (MIH16_21490) | 4554669..4555247 | - | 579 | WP_249012519.1 | TetR/AcrR family transcriptional regulator | - |
| MIH16_RS21495 (MIH16_21495) | 4555311..4555829 | + | 519 | WP_249018576.1 | HPP family protein | - |
| MIH16_RS21500 (MIH16_21500) | 4556141..4556683 | - | 543 | WP_249018578.1 | DinB family protein | - |
| MIH16_RS21505 (MIH16_21505) | 4556772..4557065 | - | 294 | WP_249006802.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| MIH16_RS21510 (MIH16_21510) | 4557062..4557436 | - | 375 | WP_249006803.1 | addiction module protein | - |
| MIH16_RS21515 (MIH16_21515) | 4557632..4558099 | - | 468 | WP_249006804.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4557632..4567828 | 10196 | |
| - | inside | Integron | - | - | 4548713..4553560 | 4847 | |
| - | inside | Integron | - | - | 4557062..4570611 | 13549 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11496.18 Da Isoelectric Point: 4.6583
>T235863 WP_249006798.1 NZ_CP092283:c4552830-4552528 [Marinobacter sp. M4C]
MKIIWSPLALERIEDISRYIAEDNPDAALQWVNDLFATVERLADFPKSGRMVPEVGAPRIRELIFGTYRVIYSVKDQVNI
LTVRRSSQLLRMSEVGDDET
MKIIWSPLALERIEDISRYIAEDNPDAALQWVNDLFATVERLADFPKSGRMVPEVGAPRIRELIFGTYRVIYSVKDQVNI
LTVRRSSQLLRMSEVGDDET
Download Length: 303 bp
>T235863 NZ_LR134442:997461-997613 [Propionibacterium australiense]
ATGAAGCGCGGTGAGGTATGGACGCTGCGGGACGACGCGTATGCGAGCAAGGCACGACCCGTCGTTGTCGTGCAGAGCGA
GGAGTTCCCGGGATTCGGCTCGGTCGTCCTCTGCCTCTTCACTGGCTTCGACTCGAGCGGCATCCCGACGTGA
ATGAAGCGCGGTGAGGTATGGACGCTGCGGGACGACGCGTATGCGAGCAAGGCACGACCCGTCGTTGTCGTGCAGAGCGA
GGAGTTCCCGGGATTCGGCTCGGTCGTCCTCTGCCTCTTCACTGGCTTCGACTCGAGCGGCATCCCGACGTGA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10633.15 Da Isoelectric Point: 6.7300
>AT235863 WP_249006799.1 NZ_CP092283:c4553108-4552827 [Marinobacter sp. M4C]
MSRVRVDEDIRPLSEFRAGVATFVKQLHETRRPMVLTQRGRGVAVLLGVHEYERMQERLEMLEEVYKAEEQIASGDGVAH
EDAKARVLSRLGQ
MSRVRVDEDIRPLSEFRAGVATFVKQLHETRRPMVLTQRGRGVAVLLGVHEYERMQERLEMLEEVYKAEEQIASGDGVAH
EDAKARVLSRLGQ
Download Length: 282 bp
>AT235863 NZ_LR134442:997229-997474 [Propionibacterium australiense]
ATGGCAACGAGGCAGATAGCCACGAGAGTTGACGCGGAGCAGGCGGAGCTCTTCAAGGAGACCACGAGGAGGCTCGGCAC
CACCCCGGCGGATGCGCTACGCATGTTCGTGACCGCCTTCAACAGCCACCGTGGTTTCCCCTATGATGTGCGCCTCTCTG
AGGATGTCGAGCCGTTCGCCACCGAGGAGGATGCCACCAGGTTCGCAACCGACCTCTCCCTGAAGGCGATCAATGAAGCG
CGGTGA
ATGGCAACGAGGCAGATAGCCACGAGAGTTGACGCGGAGCAGGCGGAGCTCTTCAAGGAGACCACGAGGAGGCTCGGCAC
CACCCCGGCGGATGCGCTACGCATGTTCGTGACCGCCTTCAACAGCCACCGTGGTTTCCCCTATGATGTGCGCCTCTCTG
AGGATGTCGAGCCGTTCGCCACCGAGGAGGATGCCACCAGGTTCGCAACCGACCTCTCCCTGAAGGCGATCAATGAAGCG
CGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|