Detailed information of TA system TA235860

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/Txe-YefM
• Location: 4521574..4522076
• Replicon: chromosome
• Accession: NZ_CP092283
• Organism: Marinobacter sp. M4C

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: MIH16_RS21225
• Protein ID: WP_249006759.1
• Coordinates: 4521574..4521837 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MIH16_RS21230
• Protein ID: WP_249006760.1
• Coordinates: 4521834..4522076 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MIH16_RS21200 (MIH16_21200)	4516854..4518320	-	1467	WP_249006754.1	ABC transporter permease	-
MIH16_RS21205 (MIH16_21205)	4518338..4518988	-	651	WP_249006755.1	ATP-binding cassette domain-containing protein	-
MIH16_RS21210 (MIH16_21210)	4518988..4519836	-	849	WP_249006756.1	putative selenate ABC transporter substrate-binding protein	-
MIH16_RS21215 (MIH16_21215)	4520116..4520754	-	639	WP_249006757.1	SGNH/GDSL hydrolase family protein	-
MIH16_RS21220 (MIH16_21220)	4521145..4521474	-	330	WP_249006758.1	DHCW motif cupin fold protein	-
MIH16_RS21225 (MIH16_21225)	4521574..4521837	-	264	WP_249006759.1	Txe/YoeB family addiction module toxin	Toxin
MIH16_RS21230 (MIH16_21230)	4521834..4522076	-	243	WP_249006760.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MIH16_RS21235 (MIH16_21235)	4522316..4523263	-	948	WP_249006761.1	D-hexose-6-phosphate mutarotase	-
MIH16_RS21240 (MIH16_21240)	4523674..4523928	-	255	WP_249006762.1	CopG family transcriptional regulator	-
MIH16_RS21245 (MIH16_21245)	4524008..4524181	-	174	WP_249006763.1	BrnT family toxin	-
MIH16_RS21250 (MIH16_21250)	4524311..4524727	-	417	WP_249006764.1	GFA family protein	-
MIH16_RS21255 (MIH16_21255)	4525079..4525375	-	297	WP_249006765.1	type II toxin-antitoxin system RelE/ParE family toxin	-
MIH16_RS21260 (MIH16_21260)	4525375..4525629	-	255	WP_249006766.1	type II toxin-antitoxin system ParD family antitoxin	-
MIH16_RS21265 (MIH16_21265)	4526243..4526725	-	483	WP_249006768.1	SgcJ/EcaC family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4521574..4530131	8557

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10073.76 Da
• Isoelectric Point: 10.2588

>T235860 WP_249006759.1 NZ_CP092283:c4521837-4521574 [Marinobacter sp. M4C]
VTWKLVYTKQAQKDAKKLAASSLKPKAQGLLALIAEDPYRRPPPFEKLIGDLAGAYSRRINIQHRVVYEVLEDERVVKVL
RLWSHYE

Nucleotide

• Length: 264 bp

>T235860 NZ_LR134442:585183-585440 [Propionibacterium australiense]
ATGAAGACGATCAGCTACACCGAATCACGGGCGCGGTACGCCGAGGTGCTTGATGCGGTCACCGACAACCGCGAGGAGGT
CATCATCACCCGGGCCGGGCACGAGCCAGTCGTCATGATCTCGCTCGCCGATTACGAATCGCTGCGCGAGACGGCCTGTC
TGATGCGTTCCCCGGAGAACTCCAGGCGGCTGCTCGACGCGGTGGAACGTCTCGAGTCCGGTGGCGGGCGCCCGCACGAG
CTCCTCCCCGGGGACTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9157.32 Da
• Isoelectric Point: 4.1317

>AT235860 WP_249006760.1 NZ_CP092283:c4522076-4521834 [Marinobacter sp. M4C]
MTGITATEARSNLYRLIDETAESHQPIVIMGKRNRAVLVSEEDWSAIQETLYLLSVPGMRESIREGMETPMDQCDEELNW

Nucleotide

• Length: 243 bp

>AT235860 NZ_LR134442:585443-585703 [Propionibacterium australiense]
GTGCTCCTCGTCTGGGACGAGAACGCCTGGGACGACTATCTGTGGTGGCGGGCCCAGGACCGCACGGGGCTCAAGCGCAT
CAACCGTCTCATCGTCGACGTGGCGCGCAACGGCAACGAGGGCATCGGCAAGCCCGAGGCACTGCGGCACGGCCTCGCCG
GCTACTGGTCGCGGCGGATCACCGACGAGCACCGGCTCGTCTACAGGATCGACGGTGAACGCATCCTCGTCGCTGCCTGT
CGCTACCACTACGGACGTTGA