Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-XRE
Location 2884124..2885775 Replicon chromosome
Accession NZ_CP092283
Organism Marinobacter sp. M4C

Toxin (Protein)


Gene name HipA3 Uniprot ID -
Locus tag MIH16_RS13530 Protein ID WP_249005373.1
Coordinates 2884124..2885437 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID -
Locus tag MIH16_RS13535 Protein ID WP_249005374.1
Coordinates 2885434..2885775 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIH16_RS13505 (MIH16_13505) 2879380..2881152 + 1773 WP_249005369.1 SLC13 family permease -
MIH16_RS13510 (MIH16_13510) 2881287..2881565 + 279 WP_249005370.1 XRE family transcriptional regulator -
MIH16_RS13515 (MIH16_13515) 2881562..2882857 + 1296 WP_249005371.1 type II toxin-antitoxin system HipA family toxin -
MIH16_RS13520 (MIH16_13520) 2882926..2883315 - 390 WP_249009006.1 helix-turn-helix transcriptional regulator -
MIH16_RS13525 (MIH16_13525) 2883434..2884075 + 642 WP_249005372.1 transposase -
MIH16_RS13530 (MIH16_13530) 2884124..2885437 - 1314 WP_249005373.1 type II toxin-antitoxin system HipA family toxin Toxin
MIH16_RS13535 (MIH16_13535) 2885434..2885775 - 342 WP_249005374.1 helix-turn-helix transcriptional regulator Antitoxin
MIH16_RS13540 (MIH16_13540) 2886124..2886291 - 168 Protein_2651 MerR family transcriptional regulator -
MIH16_RS13545 (MIH16_13545) 2886483..2886968 - 486 WP_249005375.1 hypothetical protein -
MIH16_RS13550 (MIH16_13550) 2886965..2887264 - 300 WP_249005376.1 nucleotidyltransferase domain-containing protein -
MIH16_RS13555 (MIH16_13555) 2887327..2887518 - 192 WP_249005377.1 hypothetical protein -
MIH16_RS13560 (MIH16_13560) 2887637..2887987 - 351 WP_249005378.1 MerR family transcriptional regulator -
MIH16_RS13565 (MIH16_13565) 2888133..2888435 - 303 WP_249005379.1 integration host factor subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-116)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-67)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 48949.07 Da        Isoelectric Point: 6.2499

>T235858 WP_249005373.1 NZ_CP092283:c2885437-2884124 [Marinobacter sp. M4C]
VSTVTEVILWGKSVGALLYDTETGLSTFEYDKGWLKQDVSISPLHLPPRAGRFNFPSLPQETFFGLPGVFADTLPDDFGN
AVINAWLARQGIPKSSFSPVDRLLYTGNRGMGALEYKPDGRNTQTQVSGDIKVDTLVELAQSVLDQRAGLDVAISEGDEN
NDAMSAIFQVGTSAGGARPKAVIAVNRDRSRVVSGQTPIPKGFTHYLIKFDGVKERSSTSEVFGDPQGYGRMEYAYYLMA
KDAGINMAPSELLIEGERAHFMTQRFDRDGDRKRHYQSLCAMDHADFRKPGQYSYEELMTIARTLGLPRVDAIEIFRRMV
FNVIARNQDDHTKNFGFLLDHSTAGWRLAPAFDIAYSYKPGSYWVDTHQMTINGKRDKFTRGDILAVATQIPRFESNARA
IIDQVTEVVNQWQDYARRADVHSELSQEIYSNLRLSL

Download         Length: 1314 bp

>T235858 NZ_LR134442:10720-11157 [Propionibacterium australiense]
ATGACGCAGCATCGGACACGACTCCTCGACGTCAATGTCGTCATCGCGTTGTCCCTGCCATCCCATGTTCATCACGAGAT
CGTCACGACCTGGTTCGAGGACGTCAGGGACTGGGCGACATGCCCGATCACGCAGTCGGCGTATGTACGACTGCTGCTCA
ACCAGAATGTGACGGGGTTCCGGATCGCACCAGGTGACGTCCTTGCCGGAATGGCCGCCCTGTGCGCCGTGGACGGACAC
GAGTTCCTGTCCGATGACGCACCGTTGAGTGAGCCGCTGATCGACTTCTCGGTCCTGTCCGGCAGCAAGCAGGTCACCGA
TCTTCATCTCGTCGACCTGGCGGCGCGGCATCGTGCGGTTCTTGCGACGATGGACAGCCGGATCCCGAACGCGCTCGCCC
CCGATGACCGCAGGCACGTGGAGCTGATCCCCGTCTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12460.37 Da        Isoelectric Point: 10.0404

>AT235858 WP_249005374.1 NZ_CP092283:c2885775-2885434 [Marinobacter sp. M4C]
MSQIKRSMSDLAILDELGRRLKQARLEQNITQQQIAEGMGVSRATYIRLEDGNGKLEVLVAALRVLGKLPALDAFLPDEP
YSPIAALKSAGHIRQRARPGNKPVEQDKGDLGW

Download         Length: 342 bp

>AT235858 NZ_LR134442:10481-10714 [Propionibacterium australiense]
ATGCGGACGACTCTTGATCTTGATGACAAGGTTCTGGCGGTGGCCCGTGAACGAGCGCGACGCGAAGGGATCTCCCTGGG
GCGTGCCGTGTCTCAACTGGCCCTGCTGGGCATCACCGGCATCTCATTCAAGACCGGAAGCCGCGGGGTCCCTCTGTTCA
CCCCACCGCCGGGAAGCAGCCCCCACCCGGTCACGCCTGAGCTCATCGAGCAGCACCGTGACGAAGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References