Detailed information of TA system TA235847

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 25857..26379
• Replicon: plasmid unnamed2
• Accession: NZ_CP092260
• Organism: Salmonella enterica subsp. enterica serovar Indiana strain 15

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D0QMR1
• Locus tag: MF259_RS24250
• Protein ID: WP_000220561.1
• Coordinates: 25857..26138 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G3CAG1
• Locus tag: MF259_RS24255
• Protein ID: WP_000121743.1
• Coordinates: 26128..26379 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MF259_RS24220 (MF259_24220)	21333..21569	-	237	Protein_20	hypothetical protein	-
MF259_RS24225 (MF259_24225)	21590..22384	-	795	WP_000572405.1	aminoglycoside O-phosphotransferase APH(3')-IIa	-
MF259_RS24230 (MF259_24230)	22413..23843	-	1431	Protein_22	IS4-like element IS50R family transposase	-
MF259_RS24235 (MF259_24235)	23963..24151	+	189	WP_000957857.1	hypothetical protein	-
MF259_RS24240 (MF259_24240)	24161..25360	+	1200	WP_000948429.1	IS91 family transposase	-
MF259_RS24245 (MF259_24245)	25526..25618	+	93	Protein_25	IS6 family transposase	-
MF259_RS24250 (MF259_24250)	25857..26138	-	282	WP_000220561.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MF259_RS24255 (MF259_24255)	26128..26379	-	252	WP_000121743.1	plasmid stabilization protein	Antitoxin
MF259_RS24260 (MF259_24260)	27614..28453	+	840	WP_024129959.1	replication initiation protein	-
MF259_RS24265 (MF259_24265)	28474..29316	+	843	WP_000435064.1	replication initiation protein	-
MF259_RS24270 (MF259_24270)	29320..29766	+	447	WP_001074384.1	hypothetical protein	-
MF259_RS24275 (MF259_24275)	29903..30256	+	354	WP_024129958.1	DNA distortion polypeptide 3	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	mph(A) / aph(3')-IIa	-	1..38906	38906

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11023.86 Da
• Isoelectric Point: 10.5938

>T235847 WP_000220561.1 NZ_CP092260:c26138-25857 [Salmonella enterica subsp. enterica serovar Indiana]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Nucleotide

• Length: 282 bp

>T235847 NZ_LR134406:2468056-2468457 [Arachnia propionica]
ATGATCGTCGCCCCGTCTGCGATTGCCGCCATCCTGCTGAAGGAGCCGGAGAGCAGCGGCTTCCGTGAGCTGCTGGGCAG
GCGTGGCGGCCAATTGTCCGCCCCCGGTTACCTGGAGTTGTCGATCGTGCTCACGGCGCGGGGAGTCACCGACCCAGTCG
CCACCCTCGATGCGATCCTGCTCGGCCTCGGCGTGGAGGTGGTGCCTTTCACGCCGTCACAGGCTCGCCTGGCTCAGGAG
GCCCACCTGCGTTTCGGCAGGGGCAGCGGCCATCCGGCCAGGCTGAACTTCGGTGACTGCATCAGCTACGCCCTCGCCAA
GGACACCGGGGAACCCCTTTTGTTCAAGGGAAACGACTTCGTCCACACCGATCTGAACCCCGCCTCCGGGATCTCACCCT
GA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9194.43 Da
• Isoelectric Point: 4.1683

>AT235847 WP_000121743.1 NZ_CP092260:c26379-26128 [Salmonella enterica subsp. enterica serovar Indiana]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Nucleotide

• Length: 252 bp

>AT235847 NZ_LR134406:2467814-2468059 [Arachnia propionica]
GTGAGTTTGAACATCAAGGACGAGCACATCCACGACCTGGTCCGTCGGGCCGCCACCCGGACGGGGCTGAGTCAGACCCG
CGTGGTCGAACGGGCCGTGGTTGAGCTGCTGGCCTCCCTGGAAGCGGAAGCCGCCGCCTCCGGTCTCGATCAGCTCTTGG
ACCGGGTGCATGCCGAGCTCACGGCCTCCGGCGGCGCCCTGGACTTCGACGCCCTCTACGACCCCGAGACGGAGTTGCCG
CGATGA

Structures

Toxin

• AlphaFold DB: A0A3S5I302

Antitoxin

• AlphaFold DB: A0A3S5I301