Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 25857..26379 Replicon plasmid unnamed2
Accession NZ_CP092260
Organism Salmonella enterica subsp. enterica serovar Indiana strain 15

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag MF259_RS24250 Protein ID WP_000220561.1
Coordinates 25857..26138 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag MF259_RS24255 Protein ID WP_000121743.1
Coordinates 26128..26379 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MF259_RS24220 (MF259_24220) 21333..21569 - 237 Protein_20 hypothetical protein -
MF259_RS24225 (MF259_24225) 21590..22384 - 795 WP_000572405.1 aminoglycoside O-phosphotransferase APH(3')-IIa -
MF259_RS24230 (MF259_24230) 22413..23843 - 1431 Protein_22 IS4-like element IS50R family transposase -
MF259_RS24235 (MF259_24235) 23963..24151 + 189 WP_000957857.1 hypothetical protein -
MF259_RS24240 (MF259_24240) 24161..25360 + 1200 WP_000948429.1 IS91 family transposase -
MF259_RS24245 (MF259_24245) 25526..25618 + 93 Protein_25 IS6 family transposase -
MF259_RS24250 (MF259_24250) 25857..26138 - 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MF259_RS24255 (MF259_24255) 26128..26379 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
MF259_RS24260 (MF259_24260) 27614..28453 + 840 WP_024129959.1 replication initiation protein -
MF259_RS24265 (MF259_24265) 28474..29316 + 843 WP_000435064.1 replication initiation protein -
MF259_RS24270 (MF259_24270) 29320..29766 + 447 WP_001074384.1 hypothetical protein -
MF259_RS24275 (MF259_24275) 29903..30256 + 354 WP_024129958.1 DNA distortion polypeptide 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mph(A) / aph(3')-IIa - 1..38906 38906


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T235847 WP_000220561.1 NZ_CP092260:c26138-25857 [Salmonella enterica subsp. enterica serovar Indiana]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

>T235847 NZ_LR134406:2468056-2468457 [Arachnia propionica]
ATGATCGTCGCCCCGTCTGCGATTGCCGCCATCCTGCTGAAGGAGCCGGAGAGCAGCGGCTTCCGTGAGCTGCTGGGCAG
GCGTGGCGGCCAATTGTCCGCCCCCGGTTACCTGGAGTTGTCGATCGTGCTCACGGCGCGGGGAGTCACCGACCCAGTCG
CCACCCTCGATGCGATCCTGCTCGGCCTCGGCGTGGAGGTGGTGCCTTTCACGCCGTCACAGGCTCGCCTGGCTCAGGAG
GCCCACCTGCGTTTCGGCAGGGGCAGCGGCCATCCGGCCAGGCTGAACTTCGGTGACTGCATCAGCTACGCCCTCGCCAA
GGACACCGGGGAACCCCTTTTGTTCAAGGGAAACGACTTCGTCCACACCGATCTGAACCCCGCCTCCGGGATCTCACCCT
GA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT235847 WP_000121743.1 NZ_CP092260:c26379-26128 [Salmonella enterica subsp. enterica serovar Indiana]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT235847 NZ_LR134406:2467814-2468059 [Arachnia propionica]
GTGAGTTTGAACATCAAGGACGAGCACATCCACGACCTGGTCCGTCGGGCCGCCACCCGGACGGGGCTGAGTCAGACCCG
CGTGGTCGAACGGGCCGTGGTTGAGCTGCTGGCCTCCCTGGAAGCGGAAGCCGCCGCCTCCGGTCTCGATCAGCTCTTGG
ACCGGGTGCATGCCGAGCTCACGGCCTCCGGCGGCGCCCTGGACTTCGACGCCCTCTACGACCCCGAGACGGAGTTGCCG
CGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References