Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3751..4394 Replicon plasmid unnamed2
Accession NZ_CP092260
Organism Salmonella enterica subsp. enterica serovar Indiana strain 15

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag MF259_RS24140 Protein ID WP_001044768.1
Coordinates 3978..4394 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag MF259_RS24135 Protein ID WP_001261287.1
Coordinates 3751..3981 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MF259_RS24120 (MF259_24120) 1..2226 + 2226 WP_000698737.1 P-loop NTPase fold protein -
MF259_RS24125 (MF259_24125) 2276..3175 - 900 WP_000963206.1 nucleotide-binding protein -
MF259_RS24130 (MF259_24130) 3165..3455 - 291 WP_000111771.1 hypothetical protein -
MF259_RS24135 (MF259_24135) 3751..3981 + 231 WP_001261287.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MF259_RS24140 (MF259_24140) 3978..4394 + 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
MF259_RS24145 (MF259_24145) 4556..6694 - 2139 WP_000350638.1 AAA family ATPase -
MF259_RS24150 (MF259_24150) 7048..7305 + 258 WP_000343085.1 hypothetical protein -
MF259_RS24155 (MF259_24155) 7305..7895 + 591 WP_000194575.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mph(A) / aph(3')-IIa - 1..38906 38906


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T235846 WP_001044768.1 NZ_CP092260:3978-4394 [Salmonella enterica subsp. enterica serovar Indiana]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

>T235846 NZ_LR134406:c2162714-2162367 [Arachnia propionica]
GTGCTCCGCGGCGAGATCCGGCTGGTCGATCTGGAGCCCGCACGGGCGGGAGAGGCAGACAAGCGTCGTCCGGCGATCAT
CGTCAGCAACGACCGCGCCAACACCGTCGCCGCTCGACTCGGGCGAGGCGTGGTCACGGTCGTCCCCGTCACCAGTAATA
CCGCGCGGGTCTTTCCGTTTCAGGTGCTTCTCCTCGCGGATGAGGTCGGTATCCGCTCGGATTCCAAGGCCCAGGCCGAA
CAGGTCCGAGCGGTGTCAGTCGACCGCATCGGCCCGGTGATCGGGCGCCTTCCCGCCCGCCTGGTCGCCCAACTGGATGA
GGCGCTCCGGCTGCACCTTCAGCTCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT235846 WP_001261287.1 NZ_CP092260:3751-3981 [Salmonella enterica subsp. enterica serovar Indiana]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp

>AT235846 NZ_LR134406:c2162932-2162714 [Arachnia propionica]
GTGAAGTTGAGCGTGAGTCTGTCGCCGAGCGAGGTCGCCGTGCTCGACAAGTACGCACAGTCTGCGGGTTTGAAGTCACG
ATCGGCGGCGATCCAACAGGCCATCAAGCTGCTGGGCGATCCCGACCTGGAGGATGCCTACACCGCTGCCTGGCAGGAGT
GGGAGGACGCCGGAGAGGCCGAGGCCTGGGCGGTCACCGTCGCCGACGGGGTGAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References