Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 84084..85707 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP092259 | ||
| Organism | Salmonella enterica subsp. enterica serovar Indiana strain 15 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | H9TH67 |
| Locus tag | MF259_RS23385 | Protein ID | WP_000088046.1 |
| Coordinates | 84382..85707 (+) | Length | 442 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A5Z6V2D1 |
| Locus tag | MF259_RS23380 | Protein ID | WP_024136327.1 |
| Coordinates | 84084..84377 (+) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MF259_RS23355 (MF259_23355) | 79956..81197 | + | 1242 | WP_001053338.1 | VWA domain-containing protein | - |
| MF259_RS24425 | 81288..81419 | + | 132 | WP_000374059.1 | hypothetical protein | - |
| MF259_RS23360 (MF259_23360) | 81760..82041 | - | 282 | WP_000077926.1 | hypothetical protein | - |
| MF259_RS23365 (MF259_23365) | 82091..82282 | - | 192 | WP_000398480.1 | hypothetical protein | - |
| MF259_RS23370 (MF259_23370) | 82374..82715 | - | 342 | WP_001151575.1 | hypothetical protein | - |
| MF259_RS23375 (MF259_23375) | 83088..83480 | + | 393 | WP_000341066.1 | hypothetical protein | - |
| MF259_RS23380 (MF259_23380) | 84084..84377 | + | 294 | WP_024136327.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MF259_RS23385 (MF259_23385) | 84382..85707 | + | 1326 | WP_000088046.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| MF259_RS23390 (MF259_23390) | 85768..85974 | + | 207 | WP_000134171.1 | hypothetical protein | - |
| MF259_RS23395 (MF259_23395) | 86076..86486 | + | 411 | WP_000985911.1 | hypothetical protein | - |
| MF259_RS23400 (MF259_23400) | 86499..87314 | + | 816 | WP_001572439.1 | HNH endonuclease signature motif containing protein | - |
| MF259_RS23405 (MF259_23405) | 87568..87993 | + | 426 | WP_001043843.1 | hypothetical protein | - |
| MF259_RS23410 (MF259_23410) | 88451..88687 | + | 237 | Protein_86 | type I restriction-modification system subunit M N-terminal domain-containing protein | - |
| MF259_RS23415 (MF259_23415) | 88742..89041 | + | 300 | WP_001572440.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr / aac(3)-IVa / aph(4)-Ia / sul2 / floR / blaCTX-M-65 / fosA3 / blaTEM-1B / aph(3'')-Ib / aph(6)-Id / oqxA / oqxB / aadA5 / armA | - | 1..214299 | 214299 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 442 a.a. Molecular weight: 50249.20 Da Isoelectric Point: 6.1927
>T235845 WP_000088046.1 NZ_CP092259:84382-85707 [Salmonella enterica subsp. enterica serovar Indiana]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
Download Length: 1326 bp
>T235845 NZ_LR134406:c556885-556628 [Arachnia propionica]
GTGAAGACCATGTCGTACACCGAGTCCCGGGCCAACTACGCAGCGGTCCTCGACGAGGTCGTGAACAATCGCGAGGAGAT
CATCATCACCCGGGTGGGACACGAACCCGTCGTGATCGTCTCCCTGGAGGAGTACCAGTCCCTTCGCGAGACCGCCTACC
TGTTGCGTTCGCCCGCCAACGCCCAGCGGCTGGCCAGCGCCATGGAACAGCTCGACAGGAACGACGGCATCCCGCACGAC
CTCCTCGACGACCACTGA
GTGAAGACCATGTCGTACACCGAGTCCCGGGCCAACTACGCAGCGGTCCTCGACGAGGTCGTGAACAATCGCGAGGAGAT
CATCATCACCCGGGTGGGACACGAACCCGTCGTGATCGTCTCCCTGGAGGAGTACCAGTCCCTTCGCGAGACCGCCTACC
TGTTGCGTTCGCCCGCCAACGCCCAGCGGCTGGCCAGCGCCATGGAACAGCTCGACAGGAACGACGGCATCCCGCACGAC
CTCCTCGACGACCACTGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10946.35 Da Isoelectric Point: 10.0925
>AT235845 WP_024136327.1 NZ_CP092259:84084-84377 [Salmonella enterica subsp. enterica serovar Indiana]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW
Download Length: 294 bp
>AT235845 NZ_LR134406:c556626-556366 [Arachnia propionica]
ATGCGGATCTGCTGGGCCGACGAAGCGTGGGAGGACTACCTCTGGTGGCAAACCCAGGACCGCCGGACCCTCAAGAGAAT
CAACTCCCTGATCCGGGACATCGCTCGCAACGGAAATGAGGAACTGGGCAAACCGGAGGCGCTGCGATACCAACTCTCCG
GCTACTGGTCCCGGCGTATCACTGAGGAGCATCGGCTGGTCTACCGGATCACCGACACCGAGGTCCAGATTGCCGCATGC
CGGTACCACTATGGCCGCTGA
ATGCGGATCTGCTGGGCCGACGAAGCGTGGGAGGACTACCTCTGGTGGCAAACCCAGGACCGCCGGACCCTCAAGAGAAT
CAACTCCCTGATCCGGGACATCGCTCGCAACGGAAATGAGGAACTGGGCAAACCGGAGGCGCTGCGATACCAACTCTCCG
GCTACTGGTCCCGGCGTATCACTGAGGAGCATCGGCTGGTCTACCGGATCACCGACACCGAGGTCCAGATTGCCGCATGC
CGGTACCACTATGGCCGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3T0VBU1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Z6V2D1 |