Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3857763..3858423 Replicon chromosome
Accession NZ_CP092258
Organism Salmonella enterica subsp. enterica serovar Indiana strain 15

Toxin (Protein)


Gene name cptA Uniprot ID A0A3V4SJP5
Locus tag MF259_RS18630 Protein ID WP_000244755.1
Coordinates 3857763..3858176 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag MF259_RS18635 Protein ID WP_000351186.1
Coordinates 3858157..3858423 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MF259_RS18610 (3853704) 3853704..3855437 - 1734 WP_023227724.1 single-stranded-DNA-specific exonuclease RecJ -
MF259_RS18615 (3855443) 3855443..3856156 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MF259_RS18620 (3856180) 3856180..3857076 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
MF259_RS18625 (3857189) 3857189..3857710 + 522 WP_001055885.1 flavodoxin FldB -
MF259_RS18630 (3857763) 3857763..3858176 - 414 WP_000244755.1 protein YgfX Toxin
MF259_RS18635 (3858157) 3858157..3858423 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
MF259_RS18640 (3858673) 3858673..3859653 + 981 WP_017441090.1 tRNA-modifying protein YgfZ -
MF259_RS18645 (3859736) 3859736..3860722 - 987 WP_023226548.1 IS110 family transposase -
MF259_RS18650 (3860980) 3860980..3861639 - 660 WP_000250289.1 hemolysin III family protein -
MF259_RS18655 (3861803) 3861803..3862114 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16164.10 Da        Isoelectric Point: 10.2118

>T235842 WP_000244755.1 NZ_CP092258:c3858176-3857763 [Salmonella enterica subsp. enterica serovar Indiana]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLHPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T235842 NZ_LR134396:c3791673-3791371 [Providencia rustigianii]
ATGTTGACGGTATTTACGACCGATATTTTTGATAAATGGATGCATGAACTTAAAGATATAAGAGCAAAAACAAAAATACA
GGTAAGAATTCGCCGCTTAAAAAATGGTAACTTTGGTGATGTTGAATCCATTGGTGAAGGATTTTCAGAACTAAAAATTC
ATGAAGGAAAAGGGTATAGGGTCTACTTAAAAAAAGTAGAGAATACGATAGTATTGTTAATTAATGGGGGAAGTAAATCG
ACACAGCAGAAAGATATCGACCGAGCTAAGCAAATTTTTCGTGAAATTGAAGGTGACCTATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT235842 WP_000351186.1 NZ_CP092258:c3858423-3858157 [Salmonella enterica subsp. enterica serovar Indiana]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT235842 NZ_LR134396:c3791374-3791087 [Providencia rustigianii]
ATGAGTATAAAAATAAAAGAATATGACATCGCTGAGCATCTGGCGAGCGAAGAAGAAATCCAATTATATTTGAATGAAAT
ACTTGAAGAAGGCGATCCCGCATTAATACTGTCAGCGTTAGGTGATATTGCTAGAGCGAGAAATATGACTCAGCTGGCTA
AAGATGTTGGAATGAGTCGAGAAGGCTTATATAAAGCGTTGTCTGGTCAGGGAAATCCAACGTTTACAACGATTATGAAA
ATCGTCCATTCTCTTGGATTCAAATTACAGTTTAAAAGGGCGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SJP5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References