Detailed information of TA system TA235841

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3846911..3847536
• Replicon: chromosome
• Accession: NZ_CP092258
• Organism: Salmonella enterica subsp. enterica serovar Indiana strain 15

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MF259_RS18565
• Protein ID: WP_000911337.1
• Coordinates: 3846911..3847309 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: C0PXM4
• Locus tag: MF259_RS18570
• Protein ID: WP_000557545.1
• Coordinates: 3847309..3847536 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MF259_RS18550 (3843586)	3843586..3844173	-	588	WP_023227728.1	fimbrial protein	-
MF259_RS18555 (3844892)	3844892..3845524	-	633	WP_023227727.1	YfdX family protein	-
MF259_RS18560 (3845571)	3845571..3846107	-	537	WP_023227726.1	STM3031 family outer membrane protein	-
MF259_RS18565 (3846911)	3846911..3847309	-	399	WP_000911337.1	tRNA(fMet)-specific endonuclease VapC	Toxin
MF259_RS18570 (3847309)	3847309..3847536	-	228	WP_000557545.1	toxin-antitoxin system antitoxin VapB	Antitoxin
MF259_RS18575 (3847704)	3847704..3847964	+	261	WP_023227725.1	hypothetical protein	-
MF259_RS18580 (3848239)	3848239..3849045	+	807	WP_010989071.1	DUF1460 domain-containing protein	-
MF259_RS18590 (3849330)	3849330..3850088	-	759	WP_000244318.1	amidase activator ActS	-
MF259_RS18595 (3850353)	3850353..3850898	+	546	WP_000133994.1	isopentenyl-diphosphate Delta-isomerase	-
MF259_RS18600 (3850974)	3850974..3852491	-	1518	WP_000003339.1	lysine--tRNA ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3838463..3849045	10582

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15037.43 Da
• Isoelectric Point: 7.7785

>T235841 WP_000911337.1 NZ_CP092258:c3847309-3846911 [Salmonella enterica subsp. enterica serovar Indiana]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Nucleotide

• Length: 399 bp

>T235841 NZ_LR134396:c3791374-3791087 [Providencia rustigianii]
ATGAGTATAAAAATAAAAGAATATGACATCGCTGAGCATCTGGCGAGCGAAGAAGAAATCCAATTATATTTGAATGAAAT
ACTTGAAGAAGGCGATCCCGCATTAATACTGTCAGCGTTAGGTGATATTGCTAGAGCGAGAAATATGACTCAGCTGGCTA
AAGATGTTGGAATGAGTCGAGAAGGCTTATATAAAGCGTTGTCTGGTCAGGGAAATCCAACGTTTACAACGATTATGAAA
ATCGTCCATTCTCTTGGATTCAAATTACAGTTTAAAAGGGCGCTGTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8500.48 Da
• Isoelectric Point: 5.0053

>AT235841 WP_000557545.1 NZ_CP092258:c3847536-3847309 [Salmonella enterica subsp. enterica serovar Indiana]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Nucleotide

• Length: 228 bp

>AT235841 NZ_LR134396:c3791673-3791371 [Providencia rustigianii]
ATGTTGACGGTATTTACGACCGATATTTTTGATAAATGGATGCATGAACTTAAAGATATAAGAGCAAAAACAAAAATACA
GGTAAGAATTCGCCGCTTAAAAAATGGTAACTTTGGTGATGTTGAATCCATTGGTGAAGGATTTTCAGAACTAAAAATTC
ATGAAGGAAAAGGGTATAGGGTCTACTTAAAAAAAGTAGAGAATACGATAGTATTGTTAATTAATGGGGGAAGTAAATCG
ACACAGCAGAAAGATATCGACCGAGCTAAGCAAATTTTTCGTGAAATTGAAGGTGACCTATGA

Structures

Antitoxin

• AlphaFold DB: A0A0R9MGW6