Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3690498..3691312 Replicon chromosome
Accession NZ_CP092258
Organism Salmonella enterica subsp. enterica serovar Indiana strain 15

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A4Y6MAM1
Locus tag MF259_RS17865 Protein ID WP_023227563.1
Coordinates 3690785..3691312 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID A0A4Y6M833
Locus tag MF259_RS17860 Protein ID WP_072162154.1
Coordinates 3690498..3690788 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MF259_RS17830 (3686449) 3686449..3687099 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
MF259_RS17835 (3687555) 3687555..3687998 + 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
MF259_RS17840 (3688429) 3688429..3688878 + 450 WP_000381610.1 membrane protein -
MF259_RS17845 (3688863) 3688863..3689210 + 348 WP_001669174.1 DUF1493 family protein -
MF259_RS17850 (3689483) 3689483..3689809 - 327 WP_000393302.1 hypothetical protein -
MF259_RS17855 (3690050) 3690050..3690228 + 179 Protein_3494 IS3 family transposase -
MF259_RS17860 (3690498) 3690498..3690788 + 291 WP_072162154.1 DUF1778 domain-containing protein Antitoxin
MF259_RS17865 (3690785) 3690785..3691312 + 528 WP_023227563.1 GNAT family N-acetyltransferase Toxin
MF259_RS17870 (3691385) 3691385..3691602 - 218 Protein_3497 IS5/IS1182 family transposase -
MF259_RS17875 (3691937) 3691937..3692593 + 657 WP_000420452.1 protein-serine/threonine phosphatase -
MF259_RS17880 (3692838) 3692838..3693332 - 495 WP_023227564.1 hypothetical protein -
MF259_RS17885 (3693359) 3693359..3694027 - 669 WP_000445914.1 hypothetical protein -
MF259_RS17890 (3694613) 3694613..3695011 - 399 Protein_3501 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3691385..3691525 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19099.93 Da        Isoelectric Point: 9.6420

>T235840 WP_023227563.1 NZ_CP092258:3690785-3691312 [Salmonella enterica subsp. enterica serovar Indiana]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGSVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T235840 NZ_LR134396:c3615773-3615480 [Providencia rustigianii]
ATGATATATAGTATTGAGTTTGATGAACGAGCTTTAAAGGAGTGGAAAAAACTTGATAGCAGTATTCGAGATCAATTTAA
AAATAAACTGAAAAAACTACAAAAAAATCCGCATGTTGAGTCAGCTCGGTTACATGGAGAGTTGTCAAGTTGCTATAAAA
TTAAATTGCGCTCTTCAGGCTATCGTTTAGTTTATCAAGTTATTCATTCGGAAATTGTTATTTTTGTTATTGCTATCGGA
AAAAGGGAAGCGAGTACAGCATATACAGCAGCCAATACAAGATTAGTAAAATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.54 Da        Isoelectric Point: 8.5779

>AT235840 WP_072162154.1 NZ_CP092258:3690498-3690788 [Salmonella enterica subsp. enterica serovar Indiana]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT235840 NZ_LR134396:c3616017-3615763 [Providencia rustigianii]
ATGACAACAATACAAATTAGAGTCGATGAACAATTAAAAAAAGAGGCATTTCAAGCCTTTGAAAAATTAAATTTATCCCC
ATCTGATGCACTCAGATTATTTTTACGATATGTAGCAGAGAATAAAAAATTACCTTTTACTGAGGTTTCTGTTGTCGTGA
GTGAAAGTGATGCTGATGATGAAATTTTGGCAGTAGTTCGTGAGCGTTTGAAAAAACCAGCAAAACGAATCAGAGTAAAT
TTGGATGATATATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y6MAM1

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y6M833

References