235831

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2280699..2281221 Replicon chromosome
Accession NZ_CP092258
Organism Salmonella enterica subsp. enterica serovar Indiana strain 15

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag MF259_RS10990 Protein ID WP_000221343.1
Coordinates 2280699..2280983 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag MF259_RS10995 Protein ID WP_000885424.1
Coordinates 2280973..2281221 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MF259_RS10965 (2275855) 2275855..2277096 - 1242 WP_023227499.1 MFS transporter -
MF259_RS10970 (2277086) 2277086..2278594 - 1509 WP_023227500.1 FAD-dependent oxidoreductase -
MF259_RS10975 (2278639) 2278639..2279127 + 489 WP_023227501.1 MarR family winged helix-turn-helix transcriptional regulator -
MF259_RS10980 (2279320) 2279320..2280399 + 1080 WP_023227502.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
MF259_RS10985 (2280451) 2280451..2280651 - 201 Protein_2149 Rid family hydrolase -
MF259_RS10990 (2280699) 2280699..2280983 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MF259_RS10995 (2280973) 2280973..2281221 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MF259_RS11000 (2281746) 2281746..2282078 + 333 WP_023227504.1 DUF1493 family protein -
MF259_RS11005 (2282229) 2282229..2283137 + 909 WP_077910000.1 hypothetical protein -
MF259_RS11010 (2283209) 2283209..2283496 - 288 WP_071787797.1 helix-turn-helix domain-containing protein -
MF259_RS24405 (2283960) 2283960..2284082 + 123 WP_254891910.1 hypothetical protein -
MF259_RS11015 (2284113) 2284113..2285579 - 1467 WP_023893409.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T235831 WP_000221343.1 NZ_CP092258:c2280983-2280699 [Salmonella enterica subsp. enterica serovar Indiana]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T235831 NZ_LR134395:1458680-1459072 [Haemophilus aegyptius]
ATGTATATGTTAGATACGAATACTGTGAGTTATTTTTTCCGTAAAGTGCCTTCTGTAGTAGAACGATTAAGGCTGCTTAA
TCCTGAAATTCTCTGTATTTCTTCTGTTACCGCCGCTGAATTATTTTATGGTGTGGCAAAGCGTAATAATCTGCAACTTT
CACAGTTTCTAGATATATTTTTATCTGCGATTTCTATTTTAGAATGGGATACGAAAACCGCTGAAATTTATGGCAAGCTA
AGAGCTGAAATGGAAAAAGAAGGCAAAGTAATGGGCGTACAAGATCAGATGATTGCTGCTCACGCTTTAGCTAATGAATG
TGTTTTAGTCACGAGTGATAAAGCTTTTGAGTTTGTCCCCAACTTGATTTTAGAAAATTGGTGTAGTGTTTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT235831 WP_000885424.1 NZ_CP092258:c2281221-2280973 [Salmonella enterica subsp. enterica serovar Indiana]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT235831 NZ_LR134395:1458419-1458679 [Haemophilus aegyptius]
ATGGAAAAAATCGCACGTTTATTTAGAAATGGTCGCAATCAAGCCGTTCGTTTACCTGTGGAATTTGAGTTTGACGCCAC
TCAAATTTATGTTTTCAAAGAAGAAAATGGCGATATTAGGCTTTCAACTCGTTCTCGTAGCCAGCAAAATTGGCAGAAAG
TCTTCGAATTGTTACCTACAATTCAATGTGATGAAGATTTTTTATCAGAAAAAGAGCGTAAGCAAGAAGTGGCAACGCGA
GATCCTTTTGAGGGCTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References