Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1306034..1306654 Replicon chromosome
Accession NZ_CP092258
Organism Salmonella enterica subsp. enterica serovar Indiana strain 15

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag MF259_RS06140 Protein ID WP_001280991.1
Coordinates 1306034..1306252 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag MF259_RS06145 Protein ID WP_000344807.1
Coordinates 1306280..1306654 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MF259_RS06100 (1301257) 1301257..1301826 + 570 WP_000779802.1 YbaY family lipoprotein -
MF259_RS06105 (1301859) 1301859..1302248 - 390 WP_000961285.1 MGMT family protein -
MF259_RS06115 (1302479) 1302479..1304029 - 1551 WP_023210786.1 EAL domain-containing protein -
MF259_RS06120 (1304254) 1304254..1304514 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
MF259_RS06125 (1304520) 1304520..1304660 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
MF259_RS06130 (1304716) 1304716..1305186 - 471 WP_000136181.1 YlaC family protein -
MF259_RS06135 (1305304) 1305304..1305855 - 552 WP_001278793.1 maltose O-acetyltransferase -
MF259_RS06140 (1306034) 1306034..1306252 - 219 WP_001280991.1 HHA domain-containing protein Toxin
MF259_RS06145 (1306280) 1306280..1306654 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
MF259_RS06150 (1307150) 1307150..1310299 - 3150 WP_051129102.1 efflux RND transporter permease AcrB -
MF259_RS06155 (1310322) 1310322..1311515 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T235830 WP_001280991.1 NZ_CP092258:c1306252-1306034 [Salmonella enterica subsp. enterica serovar Indiana]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T235830 NZ_LR134395:401041-401400 [Haemophilus aegyptius]
ATGTACGAGATTCTCTTTTACAGAGACCAAAATGACATTGAGCCAGTGAAAGAGTATCTGCTATCTCTGGCTCAAAATGA
AAGCAAAGATAGTCGAATTAAACTGAATAAAATTCGAGATTATGTAAAGTTATTAAGCGAACTCGGGACGTCTGTTGGCA
AACCCTATGTGAAACATTTAGACGGTGAAATTTGGGAACTTCGTCCAATTAGGGATCGCATCTTGTTTGCAAGATTAATG
GATGGTCGCTTTGTCTTACTACATCAATTTATGAAGAAAACACAAAAAACGCCAAAACGAGAAATCCAAACAGCCCAACA
ACGCTTAAGTGAATTAAAAGAGAGATTGAAAAATGAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT235830 WP_000344807.1 NZ_CP092258:c1306654-1306280 [Salmonella enterica subsp. enterica serovar Indiana]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT235830 NZ_LR134395:401393-401689 [Haemophilus aegyptius]
ATGAATAAAATCAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGAGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCTCGCATTGAAAAAGGACAAACGAATCCTCAGCTTGAAACGTTGTTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTTCCTCTAAGGGTAAAAAATGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References