Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 1306034..1306654 | Replicon | chromosome |
Accession | NZ_CP092258 | ||
Organism | Salmonella enterica subsp. enterica serovar Indiana strain 15 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | V1H8E6 |
Locus tag | MF259_RS06140 | Protein ID | WP_001280991.1 |
Coordinates | 1306034..1306252 (-) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | V1H4V6 |
Locus tag | MF259_RS06145 | Protein ID | WP_000344807.1 |
Coordinates | 1306280..1306654 (-) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MF259_RS06100 (1301257) | 1301257..1301826 | + | 570 | WP_000779802.1 | YbaY family lipoprotein | - |
MF259_RS06105 (1301859) | 1301859..1302248 | - | 390 | WP_000961285.1 | MGMT family protein | - |
MF259_RS06115 (1302479) | 1302479..1304029 | - | 1551 | WP_023210786.1 | EAL domain-containing protein | - |
MF259_RS06120 (1304254) | 1304254..1304514 | + | 261 | WP_000801415.1 | type B 50S ribosomal protein L31 | - |
MF259_RS06125 (1304520) | 1304520..1304660 | + | 141 | WP_001197749.1 | type B 50S ribosomal protein L36 | - |
MF259_RS06130 (1304716) | 1304716..1305186 | - | 471 | WP_000136181.1 | YlaC family protein | - |
MF259_RS06135 (1305304) | 1305304..1305855 | - | 552 | WP_001278793.1 | maltose O-acetyltransferase | - |
MF259_RS06140 (1306034) | 1306034..1306252 | - | 219 | WP_001280991.1 | HHA domain-containing protein | Toxin |
MF259_RS06145 (1306280) | 1306280..1306654 | - | 375 | WP_000344807.1 | Hha toxicity modulator TomB | Antitoxin |
MF259_RS06150 (1307150) | 1307150..1310299 | - | 3150 | WP_051129102.1 | efflux RND transporter permease AcrB | - |
MF259_RS06155 (1310322) | 1310322..1311515 | - | 1194 | WP_001039202.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8613.97 Da Isoelectric Point: 8.9008
>T235830 WP_001280991.1 NZ_CP092258:c1306252-1306034 [Salmonella enterica subsp. enterica serovar Indiana]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
Download Length: 219 bp
>T235830 NZ_LR134395:401041-401400 [Haemophilus aegyptius]
ATGTACGAGATTCTCTTTTACAGAGACCAAAATGACATTGAGCCAGTGAAAGAGTATCTGCTATCTCTGGCTCAAAATGA
AAGCAAAGATAGTCGAATTAAACTGAATAAAATTCGAGATTATGTAAAGTTATTAAGCGAACTCGGGACGTCTGTTGGCA
AACCCTATGTGAAACATTTAGACGGTGAAATTTGGGAACTTCGTCCAATTAGGGATCGCATCTTGTTTGCAAGATTAATG
GATGGTCGCTTTGTCTTACTACATCAATTTATGAAGAAAACACAAAAAACGCCAAAACGAGAAATCCAAACAGCCCAACA
ACGCTTAAGTGAATTAAAAGAGAGATTGAAAAATGAATAA
ATGTACGAGATTCTCTTTTACAGAGACCAAAATGACATTGAGCCAGTGAAAGAGTATCTGCTATCTCTGGCTCAAAATGA
AAGCAAAGATAGTCGAATTAAACTGAATAAAATTCGAGATTATGTAAAGTTATTAAGCGAACTCGGGACGTCTGTTGGCA
AACCCTATGTGAAACATTTAGACGGTGAAATTTGGGAACTTCGTCCAATTAGGGATCGCATCTTGTTTGCAAGATTAATG
GATGGTCGCTTTGTCTTACTACATCAATTTATGAAGAAAACACAAAAAACGCCAAAACGAGAAATCCAAACAGCCCAACA
ACGCTTAAGTGAATTAAAAGAGAGATTGAAAAATGAATAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14453.27 Da Isoelectric Point: 5.1444
>AT235830 WP_000344807.1 NZ_CP092258:c1306654-1306280 [Salmonella enterica subsp. enterica serovar Indiana]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
Download Length: 375 bp
>AT235830 NZ_LR134395:401393-401689 [Haemophilus aegyptius]
ATGAATAAAATCAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGAGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCTCGCATTGAAAAAGGACAAACGAATCCTCAGCTTGAAACGTTGTTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTTCCTCTAAGGGTAAAAAATGCCTAA
ATGAATAAAATCAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGAGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCTCGCATTGAAAAAGGACAAACGAATCCTCAGCTTGAAACGTTGTTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTTCCTCTAAGGGTAAAAAATGCCTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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