Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 574607..575123 | Replicon | chromosome |
| Accession | NZ_CP092258 | ||
| Organism | Salmonella enterica subsp. enterica serovar Indiana strain 15 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A3V5VNJ7 |
| Locus tag | MF259_RS02650 | Protein ID | WP_000220577.1 |
| Coordinates | 574839..575123 (+) | Length | 95 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | V7ISI8 |
| Locus tag | MF259_RS02645 | Protein ID | WP_000212724.1 |
| Coordinates | 574607..574849 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MF259_RS02625 (569627) | 569627..570760 | + | 1134 | WP_023226979.1 | amidohydrolase/deacetylase family metallohydrolase | - |
| MF259_RS02630 (570744) | 570744..571862 | + | 1119 | WP_023137277.1 | DgaE family pyridoxal phosphate-dependent ammonia lyase | - |
| MF259_RS02635 (571859) | 571859..572599 | + | 741 | WP_000779254.1 | KDGP aldolase family protein | - |
| MF259_RS02640 (572616) | 572616..574529 | + | 1914 | WP_023226980.1 | BglG family transcription antiterminator | - |
| MF259_RS02645 (574607) | 574607..574849 | + | 243 | WP_000212724.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| MF259_RS02650 (574839) | 574839..575123 | + | 285 | WP_000220577.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| MF259_RS02655 (575127) | 575127..575591 | - | 465 | WP_001009173.1 | anaerobic ribonucleoside-triphosphate reductase-activating protein | - |
| MF259_RS02660 (575808) | 575808..577946 | - | 2139 | WP_023226981.1 | anaerobic ribonucleoside-triphosphate reductase | - |
| MF259_RS02665 (578355) | 578355..580007 | - | 1653 | WP_000155050.1 | alpha,alpha-phosphotrehalase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 10912.71 Da Isoelectric Point: 9.8739
>T235826 WP_000220577.1 NZ_CP092258:574839-575123 [Salmonella enterica subsp. enterica serovar Indiana]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL
Download Length: 285 bp
>T235826 NZ_LR134383:c2931036-2930878 [Legionella jordanis]
ATGGCACAGGGTGATAAATCCAAATACACGGATAAACAAAAACGTAAAGCTCATCACATTGAAGAACATTATCGAGACAA
AGGCGTCTCTAAACAAGAAGCCGAAAAACGGGCTTGGGCTACCGTAAATGAACAGGACAAAGGTGGAAAAAAATCCTAA
ATGGCACAGGGTGATAAATCCAAATACACGGATAAACAAAAACGTAAAGCTCATCACATTGAAGAACATTATCGAGACAA
AGGCGTCTCTAAACAAGAAGCCGAAAAACGGGCTTGGGCTACCGTAAATGAACAGGACAAAGGTGGAAAAAAATCCTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8961.34 Da Isoelectric Point: 5.0651
>AT235826 WP_000212724.1 NZ_CP092258:574607-574849 [Salmonella enterica subsp. enterica serovar Indiana]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL
Download Length: 243 bp
>AT235826 NZ_LR134383:c2931920-2931057 [Legionella jordanis]
ATGCCTCATGGAAAACAGCAGCAACCACCGCAACATCAAGCCAAACAACCCGGCATTGAGGCCTTCATGCACCCAAAGCC
GGAATACATCTCTCCTCAGTATAAAGGAAGCGACAAGTTGCTTGGCAAAAAAGCGCTCATCACTGGAGGTGATAGTGGAA
TAGGACGAGCAGTAGCCTGTGCATTTGCACTGGAAGGGGCTGATGTCGTCATCCAGTATTTAAATACAGAACAGCAGGAT
GCAGAAGAAACAAAAGAATTCATCGAAAATGCAGGTAGAAAGTGTTGGTTGTTGCCATCGCCGCTGGACAGTTATGAAGT
TTGTGAACAACTCGTAAAAAGAGCCCTGGAGGCTTGCTCACATATTAACATTTTAGTTAATAATGCTGCTGAACAACATC
CTAAGGGTAGCGTGGATGAAATCAGTCCTGAACAATTAGAGCAAACCTTTAGAACCAACTTTTTTGCTTATTTCTATATG
GTTAAGTCTTTATTGCCTCATATGGAAAAAGGCGACGTCATTATCAATACCACTTCGGTGACGGCTTACAAAGGCAGTGA
GCATTTAATTGATTATTCAGCGACCAAAGGGGCTATCCTCGCCTTTACGCGTTCCCTTTCGCAAAATCTAATTTCGAAAG
GAATACGAGTAAATGGCGTTGCTCCAGGACCCATCTGGACCCCCTTGATTCCGGCAAGTTTTACCGCTGATGAAGTGGAG
GAATTTGGCTCTCAGGTACCAATGAGCCGGGCAGGACAGCCCTCTGAGGTGGCACCTTCCTATGTATTTCTTGCTTCAGC
AGACTCATCTTATATGACGGGACAGGTTCTCCATCCGAATGGAGGAGTAATTGTAAACAGTTAA
ATGCCTCATGGAAAACAGCAGCAACCACCGCAACATCAAGCCAAACAACCCGGCATTGAGGCCTTCATGCACCCAAAGCC
GGAATACATCTCTCCTCAGTATAAAGGAAGCGACAAGTTGCTTGGCAAAAAAGCGCTCATCACTGGAGGTGATAGTGGAA
TAGGACGAGCAGTAGCCTGTGCATTTGCACTGGAAGGGGCTGATGTCGTCATCCAGTATTTAAATACAGAACAGCAGGAT
GCAGAAGAAACAAAAGAATTCATCGAAAATGCAGGTAGAAAGTGTTGGTTGTTGCCATCGCCGCTGGACAGTTATGAAGT
TTGTGAACAACTCGTAAAAAGAGCCCTGGAGGCTTGCTCACATATTAACATTTTAGTTAATAATGCTGCTGAACAACATC
CTAAGGGTAGCGTGGATGAAATCAGTCCTGAACAATTAGAGCAAACCTTTAGAACCAACTTTTTTGCTTATTTCTATATG
GTTAAGTCTTTATTGCCTCATATGGAAAAAGGCGACGTCATTATCAATACCACTTCGGTGACGGCTTACAAAGGCAGTGA
GCATTTAATTGATTATTCAGCGACCAAAGGGGCTATCCTCGCCTTTACGCGTTCCCTTTCGCAAAATCTAATTTCGAAAG
GAATACGAGTAAATGGCGTTGCTCCAGGACCCATCTGGACCCCCTTGATTCCGGCAAGTTTTACCGCTGATGAAGTGGAG
GAATTTGGCTCTCAGGTACCAATGAGCCGGGCAGGACAGCCCTCTGAGGTGGCACCTTCCTATGTATTTCTTGCTTCAGC
AGACTCATCTTATATGACGGGACAGGTTCTCCATCCGAATGGAGGAGTAATTGTAAACAGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V5VNJ7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5H5JRI5 |