Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3856986..3857784 Replicon chromosome
Accession NZ_CP092252
Organism Escherichia coli strain ISHS7

Toxin (Protein)


Gene name yeeV Uniprot ID Q8VRA6
Locus tag MF614_RS18720 Protein ID WP_000854730.1
Coordinates 3857407..3857784 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P0SQV8
Locus tag MF614_RS18715 Protein ID WP_001285481.1
Coordinates 3856986..3857360 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MF614_RS18675 (3852961) 3852961..3853413 + 453 WP_000682723.1 hypothetical protein -
MF614_RS18680 (3853531) 3853531..3853764 + 234 WP_001213776.1 DUF905 family protein -
MF614_RS18685 (3853864) 3853864..3854685 + 822 WP_001234359.1 DUF932 domain-containing protein -
MF614_RS18690 (3854685) 3854685..3854930 + 246 WP_001164966.1 hypothetical protein -
MF614_RS18695 (3855024) 3855024..3855497 + 474 WP_001313575.1 antirestriction protein -
MF614_RS18700 (3855513) 3855513..3855989 + 477 WP_001313574.1 RadC family protein -
MF614_RS18705 (3856052) 3856052..3856273 + 222 WP_000692315.1 DUF987 domain-containing protein -
MF614_RS18710 (3856292) 3856292..3856936 + 645 WP_000086759.1 hypothetical protein -
MF614_RS18715 (3856986) 3856986..3857360 + 375 WP_001285481.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MF614_RS18720 (3857407) 3857407..3857784 + 378 WP_000854730.1 TA system toxin CbtA family protein Toxin
MF614_RS18725 (3857781) 3857781..3858273 + 493 Protein_3680 DUF5983 family protein -
MF614_RS18730 (3858352) 3858352..3859340 - 989 Protein_3681 IS630 family transposase -
MF614_RS18735 (3859488) 3859488..3861081 - 1594 Protein_3682 IS66 family transposase -
MF614_RS18740 (3861112) 3861112..3861462 - 351 WP_000624707.1 IS66 family insertion sequence element accessory protein TnpB -
MF614_RS18745 (3861459) 3861459..3861750 - 292 Protein_3684 transposase -
MF614_RS18750 (3861792) 3861792..3861986 + 195 WP_001313570.1 DUF957 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14212.21 Da        Isoelectric Point: 7.2923

>T235815 WP_000854730.1 NZ_CP092252:3857407-3857784 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR

Download         Length: 378 bp

>T235815 NZ_LR134378:c696909-696511 [Lautropia mirabilis]
ATGCTGGATACCAACATCATCATCTATCTGATGAAGAACCGGCCAGAGAGCGTAGCCAGGAAAATCTCCTCTCTTGCTCC
CCACGACAGGATCGTGATGAGTTTCGTCACCTATGGAGAGCTGCTCCAAGGTGCAGAAGGCAGTCGTGACAGGAAGAAAT
CCCACGACAACATACGCAGGATCACCCAGCGGATCCAGATCCTGTATCCAGATGAGAATACCTGCATCCACTATGGCCAT
TGGGCCGAAACACTGAAAAGGCAAGGCAGACCCATTGGCAACAACGATCTCTGGATTGCCTGTCATGCCCTGAGCGCCGG
CGCAACACTGGTCACCCATAACAGCCGGGAGTTCGCCAGGATCGAAGACCTGAATTGGCAGGATTGGGTCGAGCCATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13817.53 Da        Isoelectric Point: 4.7511

>AT235815 WP_001285481.1 NZ_CP092252:3856986-3857360 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTIG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT235815 NZ_LR134378:c697151-696915 [Lautropia mirabilis]
ATGCTGACCAAGGTATTCCAGAGCGGAAACAGCCAGGCCGTCCGGATTCCAGTCGACTTCCGCCTTGACGGAGACACGGT
GGAAATCATGAGGGCAGAGAACGGCGACCTCATCCTGCGCCCTGTCATTGACAAGGGAGAAGCTTTCCTGGACCTGTTCT
CCGGCTTCGATGAGTCTTTCATCCAGGCGCTCGAAGACAGGGACATGACGCCGCCTCAGGACCGGGATCCACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V671

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0SQV8

References