Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3527094..3527712 Replicon chromosome
Accession NZ_CP092252
Organism Escherichia coli strain ISHS7

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag MF614_RS17200 Protein ID WP_001291435.1
Coordinates 3527494..3527712 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag MF614_RS17195 Protein ID WP_000344800.1
Coordinates 3527094..3527468 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MF614_RS17185 (3522183) 3522183..3523376 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MF614_RS17190 (3523399) 3523399..3526548 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
MF614_RS17195 (3527094) 3527094..3527468 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
MF614_RS17200 (3527494) 3527494..3527712 + 219 WP_001291435.1 HHA domain-containing protein Toxin
MF614_RS17205 (3527884) 3527884..3528435 + 552 WP_000102568.1 maltose O-acetyltransferase -
MF614_RS17210 (3528551) 3528551..3529021 + 471 WP_000136192.1 YlaC family protein -
MF614_RS17215 (3529185) 3529185..3530735 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
MF614_RS17220 (3530777) 3530777..3531130 - 354 WP_000878140.1 DUF1428 domain-containing protein -
MF614_RS17230 (3531509) 3531509..3531820 + 312 WP_000409911.1 MGMT family protein -
MF614_RS17235 (3531851) 3531851..3532423 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T235814 WP_001291435.1 NZ_CP092252:3527494-3527712 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T235814 NZ_LR134375:2108665-2109075 [Veillonella dispar]
ATGAAGTATATGTTAGATACTAATATATGTATTTATGCTATCAAACAAGAGCCAGAAGTTGTACTACAGAAAATATTGAA
ACATCATCCTTCAGATATATGTATTTCATCAATTACATATGCTGAACTAATGCATGGTGTAGAAAAAAGCCAATCAAAAG
ATAAAAATAGATTAGCTTTAACACTTTTATTATCACCTATACAGATTATTGATTTCGATAGTCACGCTGCTGAAGAGTAT
GGAAAAATAAAAGCTGATTTACAATCACAAGGAAAAATTATTGGTCCTATGGATTTACTCATTGCTAGTCATGCAAAATC
AAAGGGTCTTACTATCGTTACTAACAATACAAAAGAGTTTAAAAGAGTTAATCAATTAGAAGTGGAAGATTGGTCTAAAC
CATTAAGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT235814 WP_000344800.1 NZ_CP092252:3527094-3527468 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT235814 NZ_LR134375:2108438-2108668 [Veillonella dispar]
ATGACCACAGCAAAGCTATTTGAAAATGGCCGTAGCCAGGCTGTACGATTACCAAAGGAATTTCGATTTAATGGTGATGA
AGTAATCATCAACAAAATAGGGAATGTAGTCTTACTTATGCCAAAAGATGATGAATGGGCGGGATTTGTAGCTGGTTTAT
CATTATTTACAGATGATTTTATGTGTAACGGACGGGAAGATATTGATCATCAGGAGCGTGAAGCCTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References