Detailed information of TA system TA235812

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2398762..2400350
• Replicon: chromosome
• Accession: NZ_CP092252
• Organism: Escherichia coli strain ISHS7

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A6D2FBH6
• Locus tag: MF614_RS11850
• Protein ID: WP_001125470.1
• Coordinates: 2399028..2400350 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: MF614_RS11845
• Protein ID: WP_001296726.1
• Coordinates: 2398762..2399028 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MF614_RS11845 (2398762)	2398762..2399028	+	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
MF614_RS11850 (2399028)	2399028..2400350	+	1323	WP_001125470.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
MF614_RS11855 (2400662)	2400662..2400870	+	209	Protein_2327	AraC family transcriptional regulator	-
MF614_RS11860 (2401302)	2401302..2401865	+	564	WP_001296758.1	type 1 fimbrial major subunit FimA	-
MF614_RS11865 (2402226)	2402226..2402936	+	711	WP_001195166.1	fimbria/pilus periplasmic chaperone	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49323.86 Da
• Isoelectric Point: 8.8783

>T235812 WP_001125470.1 NZ_CP092252:2399028-2400350 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTSLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Nucleotide

• Length: 1323 bp

>T235812 NZ_LR134375:c106256-105984 [Veillonella dispar]
ATGTTGAGATTAGTGCTTAGCAATAAGTTCAAAAAGGACCTAAAGTGCTCAAAGAAACGCGGTAAAGATCTCAATAAACT
CTATTCAATCATCACTAAATTACAGAACCAAACGCTATTAGATCCTAGTTATAAAGATCATCCATTAACAGGAAACTACG
AAGGCTTTAGAGAGTTACATGTCGAGCCAGATTGGCTTCTAATTTATGCAATTAAAGATGACATATTAGTATTATCTTTA
ACTCGCACGGGTAGCCACTCAGATTTATTCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT235812 WP_001296726.1 NZ_CP092252:2398762-2399028 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT235812 NZ_LR134375:c106544-106263 [Veillonella dispar]
ATGGCTAAAACAGCCTCTATCAGTTTGCGTATCGAGCCAGCTGTAAAAGCACAATTAGAAGCACTATATGCTAGCTTTGG
CATTTCCGTAACTGATGCGATTAATATTTTTCTCCACACATCACTAATGGAAGGCGGATTCCCATTTCAACCTAAACAAC
CTCGTTATAATGCAGAAACAGAAGCTGCTATTCAAGAAACGAAAGATATATTAGCAGGAAAAATAAAAGCAAAATCATAT
GCTAATGTAAAAGAAATGATTGAGGATTTAGGATTGGAGTAA

Structures

Toxin

• AlphaFold DB: A0A6D2FBH6