Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2317529..2318055 Replicon chromosome
Accession NZ_CP092252
Organism Escherichia coli strain ISHS7

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag MF614_RS11400 Protein ID WP_000323025.1
Coordinates 2317768..2318055 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag MF614_RS11395 Protein ID WP_000534858.1
Coordinates 2317529..2317768 (+) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MF614_RS11365 (2312865) 2312865..2313354 + 490 Protein_2229 class I SAM-dependent methyltransferase -
MF614_RS11370 (2313832) 2313832..2314252 + 421 Protein_2230 hypothetical protein -
MF614_RS11375 (2314908) 2314908..2315957 + 1050 Protein_2231 ISNCY family transposase -
MF614_RS11380 (2316078) 2316078..2316227 + 150 WP_011443592.1 protein YdfW -
MF614_RS11385 (2316664) 2316664..2316996 - 333 WP_001301033.1 FlxA-like family protein -
MF614_RS11390 (2317199) 2317199..2317504 - 306 WP_001326990.1 protein YdfV -
MF614_RS11395 (2317529) 2317529..2317768 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
MF614_RS11400 (2317768) 2317768..2318055 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
MF614_RS11405 (2318127) 2318127..2318282 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
MF614_RS11410 (2318499) 2318499..2318750 + 252 WP_000980994.1 protein Rem -
MF614_RS11415 (2318817) 2318817..2319095 + 279 WP_012304870.1 hypothetical protein -
MF614_RS11420 (2319097) 2319097..2320146 + 1050 WP_129468630.1 DUF968 domain-containing protein -
MF614_RS11425 (2320160) 2320160..2320912 + 753 WP_001047135.1 antitermination protein -
MF614_RS11430 (2321190) 2321190..2321279 - 90 WP_122985911.1 hypothetical protein -
MF614_RS11435 (2321334) 2321334..2321546 - 213 WP_024172454.1 cold shock-like protein CspF -
MF614_RS11440 (2321845) 2321845..2322060 + 216 WP_000066484.1 cold shock-like protein CspB -
MF614_RS11445 (2322424) 2322424..2322594 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
MF614_RS11450 (2322814) 2322814..2323029 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2292634..2360354 67720


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T235811 WP_000323025.1 NZ_CP092252:2317768-2318055 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T235811 NZ_LR134373:3375787-3375990 [Yersinia pseudotuberculosis]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCTTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT235811 WP_000534858.1 NZ_CP092252:2317529-2317768 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT235811 NZ_LR134373:3375370-3375738 [Yersinia pseudotuberculosis]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References