Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) chpIK/PemK(toxin)
Location 4118163..4118739 Replicon chromosome
Accession NZ_CP092206
Organism Leptospira weilii strain FMAS_RT1

Toxin (Protein)


Gene name chpK Uniprot ID -
Locus tag FH581_RS18510 Protein ID WP_016758518.1
Coordinates 4118398..4118739 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name chpI Uniprot ID M6QGN1
Locus tag FH581_RS18505 Protein ID WP_004495460.1
Coordinates 4118163..4118411 (+) Length 83 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FH581_RS18485 (FH581_019650) 4114186..4115379 - 1194 WP_002634320.1 M23 family metallopeptidase -
FH581_RS18490 (FH581_019655) 4117302..4117574 + 273 WP_026054228.1 transposase -
FH581_RS18495 (FH581_019660) 4117571..4117732 + 162 WP_004495447.1 IS3 family transposase -
FH581_RS18500 (FH581_019665) 4117824..4118027 + 204 WP_004495471.1 IS3 family transposase -
FH581_RS18505 (FH581_019670) 4118163..4118411 + 249 WP_004495460.1 hypothetical protein Antitoxin
FH581_RS18510 (FH581_019675) 4118398..4118739 + 342 WP_016758518.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FH581_RS18515 (FH581_019680) 4119006..4119275 + 270 WP_016758519.1 DUF6364 family protein -
FH581_RS18520 (FH581_019685) 4119265..4119687 + 423 WP_004495464.1 PIN domain-containing protein -
FH581_RS18525 (FH581_019690) 4120018..4120611 + 594 WP_004501734.1 dihydrofolate reductase family protein -
FH581_RS18530 (FH581_019695) 4120724..4121011 + 288 WP_239244854.1 hypothetical protein -
FH581_RS18535 (FH581_019700) 4121002..4121349 + 348 WP_025185097.1 IS66 family insertion sequence element accessory protein TnpB -
FH581_RS18540 (FH581_019705) 4121392..4123011 + 1620 WP_239245559.1 IS66 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-109)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 114 a.a.        Molecular weight: 12451.35 Da        Isoelectric Point: 8.6144

>T235795 WP_016758518.1 NZ_CP092206:4118398-4118739 [Leptospira weilii]
MIRGEIWWVDLGIPFGSEPGFKRPVLIIQDDSFNQSNINTIVSIAITSNLNLSEAPGNVLISKKDSNLSKDSVVNVSQIV
TLDKKRFLNKVGKLKSNKLNEVEAGLKLVTDLD

Download         Length: 342 bp

>T235795 NZ_LR134355:5317382-5317819 [Mycolicibacterium chitae]
GTGAAAATTGTCGATGCGAACGTACTTCTGTACGCGGTGAACTCCGCAAGCCCGCAGCACGAGGCGAGTCGCCGTTGGCT
AGATGGGGCCCTGTCCGGCTCGGACACCGTTGGCCTAGCGTGGGTGCCGCTGCTCGCCTTCGTTCGACTCAGCACGAAGA
CCGGCTTGTTCCCCTCCCCGCTGCCGCCGGCGGACGCGATGCGTCAGGTTGTTGAATGGGCCACCGCCCCGGGCGCGACG
ACTATCGCGCCTACCGCGCGGCATGGAGACATCCTGCACACCCTGCTCGCCCAGCTGGGGACCGGCGGAAACATCGTGAG
CGACGCGCACCTGGCTGCGCTGGCCATCGAACATCGTGCGTCGATTGTCAGCTACGACAACGACTTCAGCCGGTTCGACG
GCGTACGTTGGCACACCCCAGACGCGCTAGTCAAATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9287.59 Da        Isoelectric Point: 10.1669

>AT235795 WP_004495460.1 NZ_CP092206:4118163-4118411 [Leptospira weilii]
MKTAISIPDELFKTAEKTAKKLGIPRSQLFAKALEEFIQSHSKESVTEKLNKVYNSKSSETKNNITDLSVESLRKSLKND
SW

Download         Length: 249 bp

>AT235795 NZ_LR134355:5317131-5317385 [Mycolicibacterium chitae]
ATGCGTACGACAGTCACTCTTGACGATGACACGCTGGCGTTGGTTCAGCGGCGGATGCGCGAACGCGGCGTCTCTTTCAA
GACCGCACTCAACGACGCGATCCGCGATGGCGCCCTTGGCCAACCACGTCCCGTCCACTTCGCTACCCGGACCGCCGATC
TAGGGGTACCGACAGTGAATCTGGACCGCGCACTGCAACTCGCCGCCGAACTCGAAGACGAGGAACTACTGCGCAAGCAA
CGGCGTGGCGCGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB M6QGN1

References