Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | chpIK/PemK(toxin) |
Location | 4118163..4118739 | Replicon | chromosome |
Accession | NZ_CP092206 | ||
Organism | Leptospira weilii strain FMAS_RT1 |
Toxin (Protein)
Gene name | chpK | Uniprot ID | - |
Locus tag | FH581_RS18510 | Protein ID | WP_016758518.1 |
Coordinates | 4118398..4118739 (+) | Length | 114 a.a. |
Antitoxin (Protein)
Gene name | chpI | Uniprot ID | M6QGN1 |
Locus tag | FH581_RS18505 | Protein ID | WP_004495460.1 |
Coordinates | 4118163..4118411 (+) | Length | 83 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FH581_RS18485 (FH581_019650) | 4114186..4115379 | - | 1194 | WP_002634320.1 | M23 family metallopeptidase | - |
FH581_RS18490 (FH581_019655) | 4117302..4117574 | + | 273 | WP_026054228.1 | transposase | - |
FH581_RS18495 (FH581_019660) | 4117571..4117732 | + | 162 | WP_004495447.1 | IS3 family transposase | - |
FH581_RS18500 (FH581_019665) | 4117824..4118027 | + | 204 | WP_004495471.1 | IS3 family transposase | - |
FH581_RS18505 (FH581_019670) | 4118163..4118411 | + | 249 | WP_004495460.1 | hypothetical protein | Antitoxin |
FH581_RS18510 (FH581_019675) | 4118398..4118739 | + | 342 | WP_016758518.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
FH581_RS18515 (FH581_019680) | 4119006..4119275 | + | 270 | WP_016758519.1 | DUF6364 family protein | - |
FH581_RS18520 (FH581_019685) | 4119265..4119687 | + | 423 | WP_004495464.1 | PIN domain-containing protein | - |
FH581_RS18525 (FH581_019690) | 4120018..4120611 | + | 594 | WP_004501734.1 | dihydrofolate reductase family protein | - |
FH581_RS18530 (FH581_019695) | 4120724..4121011 | + | 288 | WP_239244854.1 | hypothetical protein | - |
FH581_RS18535 (FH581_019700) | 4121002..4121349 | + | 348 | WP_025185097.1 | IS66 family insertion sequence element accessory protein TnpB | - |
FH581_RS18540 (FH581_019705) | 4121392..4123011 | + | 1620 | WP_239245559.1 | IS66 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12451.35 Da Isoelectric Point: 8.6144
>T235795 WP_016758518.1 NZ_CP092206:4118398-4118739 [Leptospira weilii]
MIRGEIWWVDLGIPFGSEPGFKRPVLIIQDDSFNQSNINTIVSIAITSNLNLSEAPGNVLISKKDSNLSKDSVVNVSQIV
TLDKKRFLNKVGKLKSNKLNEVEAGLKLVTDLD
MIRGEIWWVDLGIPFGSEPGFKRPVLIIQDDSFNQSNINTIVSIAITSNLNLSEAPGNVLISKKDSNLSKDSVVNVSQIV
TLDKKRFLNKVGKLKSNKLNEVEAGLKLVTDLD
Download Length: 342 bp
>T235795 NZ_LR134355:5317382-5317819 [Mycolicibacterium chitae]
GTGAAAATTGTCGATGCGAACGTACTTCTGTACGCGGTGAACTCCGCAAGCCCGCAGCACGAGGCGAGTCGCCGTTGGCT
AGATGGGGCCCTGTCCGGCTCGGACACCGTTGGCCTAGCGTGGGTGCCGCTGCTCGCCTTCGTTCGACTCAGCACGAAGA
CCGGCTTGTTCCCCTCCCCGCTGCCGCCGGCGGACGCGATGCGTCAGGTTGTTGAATGGGCCACCGCCCCGGGCGCGACG
ACTATCGCGCCTACCGCGCGGCATGGAGACATCCTGCACACCCTGCTCGCCCAGCTGGGGACCGGCGGAAACATCGTGAG
CGACGCGCACCTGGCTGCGCTGGCCATCGAACATCGTGCGTCGATTGTCAGCTACGACAACGACTTCAGCCGGTTCGACG
GCGTACGTTGGCACACCCCAGACGCGCTAGTCAAATGA
GTGAAAATTGTCGATGCGAACGTACTTCTGTACGCGGTGAACTCCGCAAGCCCGCAGCACGAGGCGAGTCGCCGTTGGCT
AGATGGGGCCCTGTCCGGCTCGGACACCGTTGGCCTAGCGTGGGTGCCGCTGCTCGCCTTCGTTCGACTCAGCACGAAGA
CCGGCTTGTTCCCCTCCCCGCTGCCGCCGGCGGACGCGATGCGTCAGGTTGTTGAATGGGCCACCGCCCCGGGCGCGACG
ACTATCGCGCCTACCGCGCGGCATGGAGACATCCTGCACACCCTGCTCGCCCAGCTGGGGACCGGCGGAAACATCGTGAG
CGACGCGCACCTGGCTGCGCTGGCCATCGAACATCGTGCGTCGATTGTCAGCTACGACAACGACTTCAGCCGGTTCGACG
GCGTACGTTGGCACACCCCAGACGCGCTAGTCAAATGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9287.59 Da Isoelectric Point: 10.1669
>AT235795 WP_004495460.1 NZ_CP092206:4118163-4118411 [Leptospira weilii]
MKTAISIPDELFKTAEKTAKKLGIPRSQLFAKALEEFIQSHSKESVTEKLNKVYNSKSSETKNNITDLSVESLRKSLKND
SW
MKTAISIPDELFKTAEKTAKKLGIPRSQLFAKALEEFIQSHSKESVTEKLNKVYNSKSSETKNNITDLSVESLRKSLKND
SW
Download Length: 249 bp
>AT235795 NZ_LR134355:5317131-5317385 [Mycolicibacterium chitae]
ATGCGTACGACAGTCACTCTTGACGATGACACGCTGGCGTTGGTTCAGCGGCGGATGCGCGAACGCGGCGTCTCTTTCAA
GACCGCACTCAACGACGCGATCCGCGATGGCGCCCTTGGCCAACCACGTCCCGTCCACTTCGCTACCCGGACCGCCGATC
TAGGGGTACCGACAGTGAATCTGGACCGCGCACTGCAACTCGCCGCCGAACTCGAAGACGAGGAACTACTGCGCAAGCAA
CGGCGTGGCGCGTGA
ATGCGTACGACAGTCACTCTTGACGATGACACGCTGGCGTTGGTTCAGCGGCGGATGCGCGAACGCGGCGTCTCTTTCAA
GACCGCACTCAACGACGCGATCCGCGATGGCGCCCTTGGCCAACCACGTCCCGTCCACTTCGCTACCCGGACCGCCGATC
TAGGGGTACCGACAGTGAATCTGGACCGCGCACTGCAACTCGCCGCCGAACTCGAAGACGAGGAACTACTGCGCAAGCAA
CGGCGTGGCGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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