Detailed information of TA system TA235794

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2615828..2616456
• Replicon: chromosome
• Accession: NZ_CP092206
• Organism: Leptospira weilii strain FMAS_RT1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: M6ACJ6
• Locus tag: FH581_RS11570
• Protein ID: WP_020782132.1
• Coordinates: 2616058..2616456 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FH581_RS11565
• Protein ID: WP_036058719.1
• Coordinates: 2615828..2616058 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FH581_RS11540 (FH581_008740)	2611574..2612077	-	504	WP_004496854.1	crossover junction endodeoxyribonuclease RuvC	-
FH581_RS11545 (FH581_008745)	2612164..2612913	-	750	WP_002619561.1	YebC/PmpR family DNA-binding transcriptional regulator	-
FH581_RS11550 (FH581_008750)	2613123..2613734	+	612	WP_085986063.1	DUF3365 domain-containing protein	-
FH581_RS11555 (FH581_008760)	2614025..2614498	+	474	WP_239247958.1	hypothetical protein	-
FH581_RS11560 (FH581_008765)	2614883..2615599	+	717	WP_020782129.1	hypothetical protein	-
FH581_RS11565 (FH581_008770)	2615828..2616058	+	231	WP_036058719.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
FH581_RS11570 (FH581_008775)	2616058..2616456	+	399	WP_020782132.1	type II toxin-antitoxin system VapC family toxin	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15194.88 Da
• Isoelectric Point: 9.9146

>T235794 WP_020782132.1 NZ_CP092206:2616058-2616456 [Leptospira weilii]
MYLLGSNICIFLIKKKNTILLENLKKKLNKGIFISSLTIAELEFGIQKSEFKERNKVALIEFLTIFDILSFSDKDAESYG
LIRANLERKGNIIGSIDMLLAAQAIANNYIFVTNNTKEFKRIKDLKIEDWTR

Nucleotide

• Length: 399 bp

>T235794 NZ_LR134355:4292683-4293033 [Mycolicibacterium chitae]
ATGGCCTCGACTGAGGATCCCCGGCGAGGCCAGCTGTGGCTCGTTGCACTGGGCGCAGCCCGGCCGGGGGAACCGGGCAA
ACACCGCCCGGCCGTCATCGTTTCGACGGAGCAGCTGTTGACCGGTGAGGCTGCCGAACTTGTTGTGGTCGTACCGGTGT
CGAGTTCACGGGTCGCGACTCCGTTGCGGCCGACGCTGACCGCGGCGGACGGGGTGGACGCCGACAGTGTCGCGGTCTGT
CGCGCGGTCCGCGGCGTGGCCCGCGCCAGGTTGGTGCGTCGACTCGGAACGCTCTCGGAGTCAACGATGGGCCAGGTGGA
CCGCGCGTTGAAGATGATCTTGGATCTCTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8672.01 Da
• Isoelectric Point: 10.4907

>AT235794 WP_036058719.1 NZ_CP092206:2615828-2616058 [Leptospira weilii]
MQTAKLFINGRSQAVRLPKEFQFTGDDVLIQKVGEAVILVPKNKAWNVFLEGLNGFSNDFLGKGREQPKFDKRDKF

Nucleotide

• Length: 231 bp

>AT235794 NZ_LR134355:4292460-4292696 [Mycolicibacterium chitae]
ATGGCTACCGCAACAACTACGATCCGGGTGCCGGTGACCGTGCGCGATCGACTCGCGGCGCAAGCGCGTGAGCGTGGCGT
GAGCGTGGCGTCACTGCTGGAGGAATGGAGCGCTCGAGCTGAGCGCGAGGCCGCGTTTGCCGCCGAACGGGCAGCGACGT
TGGCCGAGGCCGACGACCCGAACGTGGCCGACGAGGAGCGTGACTGGGCTCAGGCGGATGCCGATGGCCTCGACTGA

Structures

Toxin

• AlphaFold DB: M6ACJ6