Detailed information of TA system TA235793

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 71531..72159
• Replicon: chromosome
• Accession: NZ_CP092206
• Organism: Leptospira weilii strain FMAS_RT1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: M6PYD2
• Locus tag: FH581_RS00445
• Protein ID: WP_004495849.1
• Coordinates: 71758..72159 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FH581_RS00440
• Protein ID: WP_016759326.1
• Coordinates: 71531..71761 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FH581_RS00405 (FH581_012740)	66582..67274	+	693	WP_004496073.1	cytochrome c biogenesis protein CcsA	-
FH581_RS00410 (FH581_012745)	67281..68411	+	1131	WP_002614454.1	SpoIIE family protein phosphatase	-
FH581_RS00415 (FH581_012750)	68408..69274	+	867	WP_239246765.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
FH581_RS00420 (FH581_012755)	69250..69498	+	249	WP_002614445.1	phosphoribosylformylglycinamidine synthase subunit PurS	-
FH581_RS00425 (FH581_012760)	69495..70154	+	660	WP_002614451.1	phosphoribosylformylglycinamidine synthase subunit PurQ	-
FH581_RS00430 (FH581_012765)	70266..70594	-	329	Protein_83	transposase	-
FH581_RS24010	70612..70887	-	276	Protein_84	transposase	-
FH581_RS24015	70980..71371	-	392	Protein_85	IS982 family transposase	-
FH581_RS00440 (FH581_012775)	71531..71761	+	231	WP_016759326.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FH581_RS00445 (FH581_012780)	71758..72159	+	402	WP_004495849.1	type II toxin-antitoxin system VapC family toxin	Toxin
FH581_RS00450 (FH581_012785)	72490..73596	+	1107	WP_239248304.1	HAD family hydrolase	-
FH581_RS00455 (FH581_012790)	73600..74430	+	831	WP_249739469.1	hypothetical protein	-
FH581_RS00460 (FH581_012795)	74584..75108	+	525	WP_004504335.1	hypothetical protein	-
FH581_RS00465 (FH581_012800)	75865..76071	+	207	Protein_91	endoflagellar filament sheath protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-125)

Antitoxin

• SpoVT-AbrB domain (7-46)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15600.27 Da
• Isoelectric Point: 9.2916

>T235793 WP_004495849.1 NZ_CP092206:71758-72159 [Leptospira weilii]
MTQYLLDTNICIYIINQKPESVYKKFKKIKLENIFISSITEFELKYGVQKSLHFERNLKVLEEFLSYLNILPFVSEDTNK
AAKVRVELERVGKPIGPFDLLIASQALSNKLTLVTNNEKEFTRIKEIKIENWL

Nucleotide

• Length: 402 bp

>T235793 NZ_LR134355:c2558464-2558051 [Mycolicibacterium chitae]
TTGATCTACCTGGACACGTCTGCCCTGACCAAGCTGCTCGTCGCCGAAGCCGAGACACCAGACCTGCAGTCGTGGCTCCT
CGAACAGCGCGACCACGGCGAAGACCACGCGGTGACGAGCGCCCTCGGCCGTGTCGAATTGATGAGAGCTGTTGCGCGGC
TGGGGGAGCCGGGACTTCACGAGCGTGCACTCTATCTGCTCGACGGCCTGGACATTCTGCCGTTGACCGACGCCGTGATC
ACCTTGGCCGAAACGATCGGCCCCGCCCGCCTGCGCTCACTGGACGCGATTCACCTTGCCTCGGCCGCCCAGATCAGGCG
TGAGCTCACGACGTTCGTCACCTACGACCACCGGCTGTTGGAGGGCTGTCGCGCAGTCGGTTTCGACACCGCGTCGCCGG
GCGGCTCGGCATGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8975.12 Da
• Isoelectric Point: 9.8802

>AT235793 WP_016759326.1 NZ_CP092206:71531-71761 [Leptospira weilii]
MNKAKIFKNGDSQAIRLPKDYRFKGKEVYIRKDGDNVILTPIDDAVDRFWNTVNNFSEDLLIDRNQPNGYDKRNRI

Nucleotide

• Length: 231 bp

>AT235793 NZ_LR134355:c2558739-2558461 [Mycolicibacterium chitae]
ATGGAGGCTATCGGAGTCCGCGAACTGCGGCAACACGCATCGCGATACCTCGCGCGGGTTGAAGCCGGTGAGGAACTCGG
CGTCACCAACAACGGCCGACTCGTCGCCAGACTGGTCCCGGTGCAGGACGTCGAACGGTCCCGCGAATCCCTGATCGAGG
CCGGCGTTCTGACCCCGGCCAATCGGCCGCGGAACCTCTTCGACATCATTGCCACGCCAGATCCTGGCCGTGAGCGCACC
CTGTCGGAAGTTCTCAGCGAGATGCGCGACGAACGTTGA

Structures

Toxin

• AlphaFold DB: A0A828Z772