Detailed information of TA system TA235791

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpIK/PemK(toxin)
• Location: 3541398..3541974
• Replicon: chromosome
• Accession: NZ_CP092203
• Organism: Leptospira weilii strain FMAS_PD2

Toxin (Protein)

• Gene name: chpK
• Uniprot ID: -
• Locus tag: FH586_RS18030
• Protein ID: WP_016758518.1
• Coordinates: 3541398..3541739 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: chpI
• Uniprot ID: M6QGN1
• Locus tag: FH586_RS18035
• Protein ID: WP_004495460.1
• Coordinates: 3541726..3541974 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FH586_RS18005 (FH586_17985)	3537328..3538032	+	705	WP_061219309.1	glycosyltransferase	-
FH586_RS18010 (FH586_17990)	3538036..3539235	+	1200	WP_061235367.1	hypothetical protein	-
FH586_RS18015 (FH586_17995)	3539526..3540119	-	594	WP_004501734.1	dihydrofolate reductase family protein	-
FH586_RS18020 (FH586_18000)	3540450..3540872	-	423	WP_004495464.1	PIN domain-containing protein	-
FH586_RS18025 (FH586_18005)	3540862..3541131	-	270	WP_016758519.1	DUF6364 family protein	-
FH586_RS18030 (FH586_18010)	3541398..3541739	-	342	WP_016758518.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
FH586_RS18035 (FH586_18015)	3541726..3541974	-	249	WP_004495460.1	hypothetical protein	Antitoxin
FH586_RS18040 (FH586_18020)	3542110..3542277	-	168	WP_080590975.1	IS3 family transposase	-
FH586_RS18045 (FH586_18025)	3542405..3542566	-	162	WP_004495447.1	IS3 family transposase	-
FH586_RS18050 (FH586_18030)	3542563..3542835	-	273	WP_026054228.1	transposase	-
FH586_RS18055 (FH586_18035)	3544440..3545633	+	1194	WP_002634320.1	M23 family metallopeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-109)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12451.35 Da
• Isoelectric Point: 8.6144

>T235791 WP_016758518.1 NZ_CP092203:c3541739-3541398 [Leptospira weilii]
MIRGEIWWVDLGIPFGSEPGFKRPVLIIQDDSFNQSNINTIVSIAITSNLNLSEAPGNVLISKKDSNLSKDSVVNVSQIV
TLDKKRFLNKVGKLKSNKLNEVEAGLKLVTDLD

Nucleotide

• Length: 342 bp

>T235791 NZ_LR134355:c2510742-2510164 [Mycolicibacterium chitae]
ATGAAGCGGCTGGACCTCGTCATCGGCTGCAACGGCGCCGGAAAATCTACCTTCGTGGAGCTGACCCTGGCGCCCCTGCT
GCCGGGTAGCGCGTTCGTCAATGCCGACGAGATCGCCAAGCGGCGTTGGCCCGCTGATGCCGCCGAACACGCCTACGAGG
CCGCGCGTACCGCGGCCGCCACCCGCGCCCGGCTCATCGAACTCGGTGAATCGTTCATCGCCGAGACCGTGTTCTCACAC
CCATCGAAGCTCGAACTCGTCGACACGGCCCTCGCAGCCGGCTACGTCGTGGCCCTGCACGTCGTGCTGATCCCCGAAGA
GCTCGCGGTGCTGCGCGTGGCCCACCGCGTCACCGCCGGCGGACACGCGGTGCCCGAGAACAAGATCCGGGAACGCTACG
GGCGGGTATGGGAGCTGGCCGCCCGCGCCGCGCAGCGGGTCGATTCAGCCACGTTCTACGACAACAGCACCCGACGAGGA
CCTCGTATCGTCGCCCAACTACACGGCGGTTTCATCGTCGGTCAGCCCCGCTGGCCGGACTGGACGCCAACGGCGTTCAC
CGACCGCTGGCCCGCCTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9287.59 Da
• Isoelectric Point: 10.1669

>AT235791 WP_004495460.1 NZ_CP092203:c3541974-3541726 [Leptospira weilii]
MKTAISIPDELFKTAEKTAKKLGIPRSQLFAKALEEFIQSHSKESVTEKLNKVYNSKSSETKNNITDLSVESLRKSLKND
SW

Nucleotide

• Length: 249 bp

>AT235791 NZ_LR134355:c2511160-2510771 [Mycolicibacterium chitae]
ATGACGGATACCACCGACCGGGTGACCCGGTTCGCCGCGGACCTCGTCGATGCCGCGGCGGTCGAAGGTGCCCGCCAGAG
CCGCTCGGCCAAACAACAACTCGACCACTGGGCGCGGGTCGGCCGCGCGGTCTCCAGCCAGCACAGCGCCGCACGCCGCA
AGGTCGAAGCCGCGTTGGCCGGCGAAACCCCCCTGCGCAACCTCAGCCCCGAGGAGGGCGTGGCGTTCAACGCAGAGATC
ACCGCCGCCCTCGAGGAAAACTTGGCGCGCACCGACTACGGGCAGATTCTTGCCGACCGCGGCGTGACCACCGTCGCCCT
CGATGACGATGGACAGATCGTGCAGTACCGGCCCGATGGAACGACGGCGGTGCTGGAACCTCGTCCGTGA

Structures

Antitoxin

• AlphaFold DB: M6QGN1