Detailed information of TA system TA235790

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3456336..3456964
• Replicon: chromosome
• Accession: NZ_CP092203
• Organism: Leptospira weilii strain FMAS_PD2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: M6PYD2
• Locus tag: FH586_RS17615
• Protein ID: WP_004495849.1
• Coordinates: 3456336..3456737 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FH586_RS17620
• Protein ID: WP_016759326.1
• Coordinates: 3456734..3456964 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FH586_RS17595 (FH586_17575)	3451910..3452629	-	720	WP_002616817.1	flagellar filament outer layer protein FlaA	-
FH586_RS17600 (FH586_17580)	3453387..3453911	-	525	WP_004499241.1	hypothetical protein	-
FH586_RS17605 (FH586_17585)	3454065..3454895	-	831	WP_004495798.1	hypothetical protein	-
FH586_RS17610 (FH586_17590)	3454899..3456005	-	1107	WP_239248304.1	HAD family hydrolase	-
FH586_RS17615 (FH586_17595)	3456336..3456737	-	402	WP_004495849.1	type II toxin-antitoxin system VapC family toxin	Toxin
FH586_RS17620 (FH586_17600)	3456734..3456964	-	231	WP_016759326.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FH586_RS22610	3457209..3457751	+	543	Protein_3123	transposase	-
FH586_RS22615	3457901..3458229	+	329	Protein_3124	transposase	-
FH586_RS17630 (FH586_17610)	3458341..3459000	-	660	WP_002614451.1	phosphoribosylformylglycinamidine synthase subunit PurQ	-
FH586_RS17635 (FH586_17615)	3458997..3459245	-	249	WP_002614445.1	phosphoribosylformylglycinamidine synthase subunit PurS	-
FH586_RS17640 (FH586_17620)	3459221..3460087	-	867	WP_239246765.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
FH586_RS17645 (FH586_17625)	3460084..3461214	-	1131	WP_004499160.1	SpoIIE family protein phosphatase	-
FH586_RS17650 (FH586_17630)	3461221..3461913	-	693	WP_004496073.1	cytochrome c biogenesis protein CcsA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-125)

Antitoxin

• SpoVT-AbrB domain (7-46)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15600.27 Da
• Isoelectric Point: 9.2916

>T235790 WP_004495849.1 NZ_CP092203:c3456737-3456336 [Leptospira weilii]
MTQYLLDTNICIYIINQKPESVYKKFKKIKLENIFISSITEFELKYGVQKSLHFERNLKVLEEFLSYLNILPFVSEDTNK
AAKVRVELERVGKPIGPFDLLIASQALSNKLTLVTNNEKEFTRIKEIKIENWL

Nucleotide

• Length: 402 bp

>T235790 NZ_LR134355:1896265-1896642 [Mycolicibacterium chitae]
GTGGTCATCGACGCAAGTGCCATGGTGGACCTCGTCGCCCGCACGGATCGCTTCGCCGCAGTCCGGGCAAGGCTGGCGCG
GACGGTGATGCATGCACCGGCCCACTTCGACGCCGAAGTGCTCTCGGCGCTGGGACGCCTGCAACGTGCGGCTGTACTGA
CCGTGGCGGAAGTCGATGCAGCCCTTGATGAACTCCGGCAGGCGCCGGTGACACGGCACGCTCTCCCGTCGCTGCTTTCC
GGCGCGTGGGCGCGTCGCGACACGTTGCGCCTGGCTGATGCGCTCTACGTCGAATTGGCCGAGACGGCCGGTTTGACCTT
GCTGACGACGGACCAAAGGTTGGCGCGCGCGGCGCAAGTGGCCGACGTCATCGCCTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8975.12 Da
• Isoelectric Point: 9.8802

>AT235790 WP_016759326.1 NZ_CP092203:c3456964-3456734 [Leptospira weilii]
MNKAKIFKNGDSQAIRLPKDYRFKGKEVYIRKDGDNVILTPIDDAVDRFWNTVNNFSEDLLIDRNQPNGYDKRNRI

Nucleotide

• Length: 231 bp

>AT235790 NZ_LR134355:1896023-1896241 [Mycolicibacterium chitae]
ATGGCTCGCTTGAACGTGTACGTGCCCGACGAACTGGCTGAACGCGCCCGGGCGCGGGGCCTGAACGTCTCGGCGCTGAC
GCAGGCCGCGATCCGCGCGGAGTTGGACGACTCCGCCACCGACGCGTGGCTCGAGGCCTTGGCGCCGAGAAGCACCCGGG
CGCGGCATGACGATGTGCTGGATGCCATCGACGCCGCCCGCGACGAACTCGGCGCGTGA

Structures

Toxin

• AlphaFold DB: A0A828Z772