Detailed information of TA system TA235789

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 877171..877799
• Replicon: chromosome
• Accession: NZ_CP092203
• Organism: Leptospira weilii strain FMAS_PD2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: M6ACJ6
• Locus tag: FH586_RS06200
• Protein ID: WP_020782132.1
• Coordinates: 877171..877569 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FH586_RS06205
• Protein ID: WP_036058719.1
• Coordinates: 877569..877799 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FH586_RS06200 (FH586_06170)	877171..877569	-	399	WP_020782132.1	type II toxin-antitoxin system VapC family toxin	Toxin
FH586_RS06205 (FH586_06175)	877569..877799	-	231	WP_036058719.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
FH586_RS06210 (FH586_06180)	878028..878744	-	717	WP_020782129.1	hypothetical protein	-
FH586_RS06215 (FH586_06185)	879129..879602	-	474	WP_239247958.1	hypothetical protein	-
FH586_RS06220 (FH586_06195)	879893..880504	-	612	WP_085986063.1	DUF3365 domain-containing protein	-
FH586_RS06225 (FH586_06200)	880714..881463	+	750	WP_002619561.1	YebC/PmpR family DNA-binding transcriptional regulator	-
FH586_RS06230 (FH586_06205)	881550..882053	+	504	WP_004496854.1	crossover junction endodeoxyribonuclease RuvC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15194.88 Da
• Isoelectric Point: 9.9146

>T235789 WP_020782132.1 NZ_CP092203:c877569-877171 [Leptospira weilii]
MYLLGSNICIFLIKKKNTILLENLKKKLNKGIFISSLTIAELEFGIQKSEFKERNKVALIEFLTIFDILSFSDKDAESYG
LIRANLERKGNIIGSIDMLLAAQAIANNYIFVTNNTKEFKRIKDLKIEDWTR

Nucleotide

• Length: 399 bp

>T235789 NZ_LR134355:1889487-1889876 [Mycolicibacterium chitae]
ATGGTCATCGACACCTCTGCGCTGGTCGCAATGTTGACCGACGAAGCCGACGCAGTACTTCTCGAAGCCCGCGTGGCAGA
GGATCCGGTGCGGACGATGTCCACCGCGTCGTATTTGGAGACGGCGATTGTGATCGAAGCTCGATACGGTGAAGCCGGCG
GTCGCGAATTGGACCTATGGCTCCATCGGGCATCGGTGGACCTCGTCCCTGTCACCGCTGACCAAGCTGAGGTTGCGCGG
CGCGCCTACCGGCAGTACGGCAAGGGGTGCCACCCTGCCGGCCTGAACTACGGCGATTGCTTCTCCTACGCTTTGGCCAA
GGTGAACGGTCAGCCGTTGCTGTTCAAGGGCGATGGCTTTCAGCACACGGATGTCGTTGCAGCCCAATGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8672.01 Da
• Isoelectric Point: 10.4907

>AT235789 WP_036058719.1 NZ_CP092203:c877799-877569 [Leptospira weilii]
MQTAKLFINGRSQAVRLPKEFQFTGDDVLIQKVGEAVILVPKNKAWNVFLEGLNGFSNDFLGKGREQPKFDKRDKF

Nucleotide

• Length: 231 bp

>AT235789 NZ_LR134355:1889233-1889487 [Mycolicibacterium chitae]
ATGGCACTAAGTATCAAAGATCCCGAGGCCGACCGACTGGCCCGGCAACTCGCTGCGCAGACCGGAGAGACTTTGACGGA
AGTGGTGGTGGTGGCGTTGCGTGAGCGCCTGGCGCGCCAATCCAATCGGGTACGCGTCGCTCCACTACGCGAGGAACTCG
CGGCGATCCGACGGCGCTGCGCGGCACTCGAGGTCAAGGATGACCGCGCCGCCGAGGCGATCTTGGGCTACGACGACCGC
GGTCTACCGTCCTGA

Structures

Toxin

• AlphaFold DB: M6ACJ6